2004
Roles of the Proline-rich Domain in SLP-76 Subcellular Localization and T Cell Function* [boxs]
Singer AL, Bunnell SC, Obstfeld AE, Jordan MS, Wu JN, Myung PS, Samelson LE, Koretzky GA. Roles of the Proline-rich Domain in SLP-76 Subcellular Localization and T Cell Function* [boxs]. Journal Of Biological Chemistry 2004, 279: 15481-15490. PMID: 14722089, DOI: 10.1074/jbc.m313339200.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAlanineAntigens, CDAntigens, Differentiation, T-LymphocyteArginineBlotting, WesternCalciumCell LineCell LineageFlow CytometryGene DeletionGenes, DominantHematopoietic Stem CellsHumansJurkat CellsLectins, C-TypeLuciferasesLymphocyte ActivationLysineMembrane MicrodomainsModels, BiologicalMutationPhosphoproteinsPlasmidsPrecipitin TestsProlineProtein Structure, TertiarySignal TransductionSrc Homology DomainsSubcellular FractionsTime FactorsT-LymphocytesTransfectionConceptsSLP-76P1 domainSLP-76 functionProline-rich domainProline-rich regionDomain deletion mutantMultiple hematopoietic lineagesLeukocyte-specific phosphoproteinSrc homologyDeletion mutantsSignal transductionSubcellular localizationHematopoietic lineagesFunctional roleProtein fragmentsT cell receptorMolecular scaffoldsCell functionCell receptorLocalizationComplementary approachesDomainT cell functionMolecular associationDirect evidence
2001
Coupling of the TCR to Integrin Activation by SLAP-130/Fyb
Peterson E, Woods M, Dmowski S, Derimanov G, Jordan M, Wu J, Myung P, Liu Q, Pribila J, Freedman B, Shimizu Y, Koretzky G. Coupling of the TCR to Integrin Activation by SLAP-130/Fyb. Science 2001, 293: 2263-2265. PMID: 11567141, DOI: 10.1126/science.1063486.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdaptor Proteins, Signal TransducingAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCarrier ProteinsCD3 ComplexCell AdhesionCell MembraneImmunologic CappingIntercellular Adhesion Molecule-1Interleukin-2Lectins, C-TypeLymphocyte ActivationLymphocyte Function-Associated Antigen-1MicePhosphatidylinositol 3-KinasesPhosphoproteinsProtein-Tyrosine KinasesReceptors, Antigen, T-CellReceptors, Interleukin-2Signal TransductionT-LymphocytesNotch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength
Izon D, Punt J, Xu L, Karnell F, Allman D, Myung P, Boerth N, Pui J, Koretzky G, Pear W. Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength. Immunity 2001, 14: 253-264. PMID: 11290335, DOI: 10.1016/s1074-7613(01)00107-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCD4-Positive T-LymphocytesCD5 AntigensCD8-Positive T-LymphocytesCell DifferentiationDNA-Binding ProteinsFlow CytometryGene Expression RegulationHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansJurkat CellsLectins, C-TypeLiverMembrane ProteinsMiceMice, TransgenicNFATC Transcription FactorsNuclear ProteinsPromoter Regions, GeneticReceptor, Notch1Receptors, Antigen, T-CellReceptors, Cell SurfaceResponse ElementsSignal TransductionThymus GlandTranscription Factor AP-1Transcription FactorsConceptsTCR signal strengthCell fate decisionsJurkat T cellsTCR-mediated signalingT cell developmentFate decisionsMultiple lineagesNotch signalingDevelopmental arrestCell developmentNotch expressionThymocyte developmentTCR stimulationRetroviral expressionT cellsPhysiological regulationSingle-positive T cellsTCR transgenic thymocytesDifferentiation of immatureTransgenic thymocytesNotch1Maturation of CD4SignalingMouse thymocytesThymocytes