Coupling of the TCR to Integrin Activation by SLAP-130/Fyb
Peterson E, Woods M, Dmowski S, Derimanov G, Jordan M, Wu J, Myung P, Liu Q, Pribila J, Freedman B, Shimizu Y, Koretzky G. Coupling of the TCR to Integrin Activation by SLAP-130/Fyb. Science 2001, 293: 2263-2265. PMID: 11567141, DOI: 10.1126/science.1063486.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdaptor Proteins, Signal TransducingAnimalsAntigens, CDAntigens, Differentiation, T-LymphocyteCarrier ProteinsCD3 ComplexCell AdhesionCell MembraneImmunologic CappingIntercellular Adhesion Molecule-1Interleukin-2Lectins, C-TypeLymphocyte ActivationLymphocyte Function-Associated Antigen-1MicePhosphatidylinositol 3-KinasesPhosphoproteinsProtein-Tyrosine KinasesReceptors, Antigen, T-CellReceptors, Interleukin-2Signal TransductionT-LymphocytesSeparation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells
Allman D, Karnell F, Punt J, Bakkour S, Xu L, Myung P, Koretzky G, Pui J, Aster J, Pear W. Separation of Notch1 Promoted Lineage Commitment and Expansion/Transformation in Developing T Cells. Journal Of Experimental Medicine 2001, 194: 99-106. PMID: 11435476, PMCID: PMC2193437, DOI: 10.1084/jem.194.1.99.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone MarrowCell LineageDNA-Binding ProteinsHematopoietic Stem CellsHyaluronan ReceptorsLeukemia, T-CellMembrane ProteinsMiceMice, TransgenicReceptor, Notch1Receptors, Antigen, T-Cell, alpha-betaReceptors, Cell SurfaceReceptors, Interleukin-2Signal TransductionThymus GlandT-LymphocytesTranscription FactorsConceptsT lineage commitmentT cell developmentHematopoietic stem cellsLineage commitmentCell developmentSrc homology 2 domainPre-T cell receptorBone marrowT cell-specific signalsBM transferT cellsCell-specific signalsMultipotent progenitor cellsDouble-positive T cellsTCR-beta transgeneLeukocyte proteinBM cell populationsFunction of Notch1T-cell leukemiaLater time pointsCD3 epsilonActive Notch1Beta transgeneBM cellsCell leukemia