2018
Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing
Lim CH, Sun Q, Ratti K, Lee SH, Zheng Y, Takeo M, Lee W, Rabbani P, Plikus MV, Cain JE, Wang DH, Watkins DN, Millar S, Taketo MM, Myung P, Cotsarelis G, Ito M. Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing. Nature Communications 2018, 9: 4903. PMID: 30464171, PMCID: PMC6249328, DOI: 10.1038/s41467-018-07142-9.Peer-Reviewed Original ResearchConceptsSonic hedgehog pathwayMechanisms of scarringHair follicle neogenesisHF neogenesisFibrotic repairScarring woundsMurine skinShh overexpressionWound repairHair follicle regenerationWound healingFollicle neogenesisHedgehog pathwayDermal papillaWnt activationFibrosisWoundsScarringHealingSignal activationNeogenesisActivation resultsMammalian woundsActivationFollicle regenerationDissecting Wnt Signaling for Melanocyte Regulation during Wound Healing
Sun Q, Rabbani P, Takeo M, Lee SH, Lim CH, Noel ES, Taketo MM, Myung P, Millar S, Ito M. Dissecting Wnt Signaling for Melanocyte Regulation during Wound Healing. Journal Of Investigative Dermatology 2018, 138: 1591-1600. PMID: 29428355, PMCID: PMC6019608, DOI: 10.1016/j.jid.2018.01.030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCicatrixDisease Models, AnimalFemaleHumansIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsKeratinocytesMaleMelanocytesMiceMice, TransgenicReceptors, G-Protein-CoupledRegenerationSkinSkin PigmentationStem CellsWnt ProteinsWnt Signaling PathwayWound HealingConceptsMelanocyte stem cellsMelanocyte regenerationEpidermal melanocytesStem cellsWnt ligand secretionActivation of WntWound healingSignal regulationEssential functionsWnt inhibitor Dkk1Wnt ligandsLigand secretionVital regulatorWnt pathwayTransgenic expressionWntMolecular windowΒ-cateninMelanocyte regulationInhibitor DKK1Epithelial cellsMelanocytesWound scarsRegulationAbnormal pigmentation
2017
Cutaneous Fibrosis and Normal Wound Healing
Hamburg-Shields E, Myung P, Cowper S. Cutaneous Fibrosis and Normal Wound Healing. 2017, 577-600. DOI: 10.1007/978-3-319-29785-9_32.ChaptersNumerous cell typesWound healingOrchestrated processEnvironmental perturbationsTranslational mechanismsCell typesExtracellular matrixNormal roleCutaneous wound healingCoordinated productionNormal wound healingCellular playersEnvironmental influencesNormal cutaneous wound healingInjury repairIndividualized functionsMechanismProteinSpecific timeProductionCutaneous fibrosisUnnecessary scarsDisruptionMaintenance