2011
NKG2A is a marker for acquisition of regulatory function by human CD8+ T cells activated with anti‐CD3 antibody
Ablamunits V, Henegariu O, Preston‐Hurlburt P, Herold KC. NKG2A is a marker for acquisition of regulatory function by human CD8+ T cells activated with anti‐CD3 antibody. European Journal Of Immunology 2011, 41: 1832-1842. PMID: 21538351, PMCID: PMC3517122, DOI: 10.1002/eji.201041258.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalBiomarkersCD3 ComplexCD8-Positive T-LymphocytesGene ExpressionHumansInterleukin-2 Receptor alpha SubunitLymphocyte ActivationMicroarray AnalysisNK Cell Lectin-Like Receptor Subfamily CPolymerase Chain ReactionProtein IsoformsReceptors, Tumor Necrosis Factor, Type IIT-Lymphocytes, RegulatoryConceptsT cellsHuman CD8Response of CD8Induction of CD8Inhibitory receptor NKG2AType 1 diabetesAnti-CD3 mAbAnti-CD3 antibodyAcquisition of CD8NKG2A expressionTreg activityTreg inductionDrug therapyCD8TregsImmune responseNKG2ARegulatory functionsNegative signalingMarkersInductionCellsNegative markersDiabetesPatients
2002
Dual receptor T cells extend the immune repertoire for foreign antigens
He X, Janeway CA, Levine M, Robinson E, Preston-Hurlburt P, Viret C, Bottomly K. Dual receptor T cells extend the immune repertoire for foreign antigens. Nature Immunology 2002, 3: 127-134. PMID: 11812989, DOI: 10.1038/ni751.Peer-Reviewed Original ResearchConceptsDual TCR cellsT cell receptorTCR cellsForeign antigensT cellsDual-receptor T cellsFunctional T cell receptorSecond T cell receptorReceptor T cellsAutoimmune potentialIntrathymic selectionTCR repertoireNormal miceImmune responseImmune systemCell receptorNaïve repertoireAntigenClonal expansionImmune repertoireBeneficial roleCellsMost studiesMiceReceptors
1993
Rules for the Presentation of Peptides by Class II Molecules of the Major Histocompatibility Complex
Janeway C, Preston-Hurlburt P, Al-Ramadi B, Rothbard J, Murphy D, Reich E, Rudensky A. Rules for the Presentation of Peptides by Class II Molecules of the Major Histocompatibility Complex. 1993, 181-188. DOI: 10.1007/978-3-642-51479-1_24.Peer-Reviewed Original ResearchCD4 T cellsClass II moleculesMHC class II moleculesMajor histocompatibility complexT cellsSelf peptidesSelf toleranceCD8 cytolytic T cellsHistocompatibility complexT cell responsesAdaptive immune responsesCytolytic T cellsSelf-MHC recognitionPresentation of peptidesCD4 TImmune responseAdaptive immunityMHC recognitionB cellsSpecific antigenCell responsesCellsPeptidesSingle peptide