2024
Microbe Profile: Bacteriophage ϕ6: a model for segmented RNA viruses and the evolutionary consequences of viral ‘sex’
Turner P, Chao L. Microbe Profile: Bacteriophage ϕ6: a model for segmented RNA viruses and the evolutionary consequences of viral ‘sex’. Microbiology 2024, 170: 001467. PMID: 39046321, PMCID: PMC11316545, DOI: 10.1099/mic.0.001467.Peer-Reviewed Original ResearchConceptsEukaryotic virusesHost-pathogen interactionsEvolution of sexDsRNA virusesEvolutionary consequencesSegment reassortmentBacterial virusesRNA virusesRate of adaptationMutation ratePhenotypic complexityMutation loadLipid envelopeBacteriophageReassortmentRNAMutationsVirusMolecular modelingDsRNAExperimental systemGeneticsTraitsHostReplicationExperimental Evolution Studies in Φ6 Cystovirus
Singhal S, Balitactac A, Nayagam A, Bahrami P, Nayeem S, Turner P. Experimental Evolution Studies in Φ6 Cystovirus. Viruses 2024, 16: 977. PMID: 38932268, PMCID: PMC11209170, DOI: 10.3390/v16060977.Peer-Reviewed Original ResearchConceptsExperimental evolution studiesFitness effects of spontaneous mutationsSpontaneous mutationsEffects of spontaneous mutationsEvolution of RNA virusesEvolution studiesEvolution of host rangeFast generation timesResponse to selectionMultiple phagesNon-pathogenic modelRNA genomeConsequence of evolutionOuter membraneHost rangeRNA virusesNovel traitsMutation rateHost cellsFitness effectsPopulation sizeMutationsCystovirusesBacteriophageGeneration time
2023
Experimental Evolution of the TolC-Receptor Phage U136B Functionally Identifies a Tail Fiber Protein Involved in Adsorption through Strong Parallel Adaptation
Burmeister A, Tzintzun-Tapia E, Roush C, Mangal I, Barahman R, Bjornson R, Turner P. Experimental Evolution of the TolC-Receptor Phage U136B Functionally Identifies a Tail Fiber Protein Involved in Adsorption through Strong Parallel Adaptation. Applied And Environmental Microbiology 2023, 89: e00079-23. PMID: 37191555, PMCID: PMC10304864, DOI: 10.1128/aem.00079-23.Peer-Reviewed Original ResearchConceptsExperimental evolutionPhage populationsParallel molecular evolutionWhole-population sequencingAntibiotic resistance proteinsTail fiber proteinE. coli hostPhage evolutionEvolutionary potentialMolecular evolutionPhage genotypesTolC proteinParallel adaptationProtein geneAntibiotic resistanceExperimental populationsBacterial diversitySelection pressureBacterial hostsColi hostFiber proteinBacterial populationsBacterial cellsPhage resistancePhage dynamics
2013
STOCHASTIC TEMPERATURES IMPEDE RNA VIRUS ADAPTATION
Alto BW, Wasik BR, Morales NM, Turner PE. STOCHASTIC TEMPERATURES IMPEDE RNA VIRUS ADAPTATION. Evolution 2013, 67: 969-979. PMID: 23550749, DOI: 10.1111/evo.12034.Peer-Reviewed Original ResearchConceptsFitness gainsVesicular stomatitis virusEvolution of generalistsConvergent molecular evolutionEvolution of specializationCell-binding proteinsMolecular evolutionGenome substitutionsConstant environmentVirus adaptationSequence analysisRNA virusesG geneVirus populationsStomatitis virusMolecular changesLineagesGeneralistsTemperature treatmentKey roleEvolutionGenesLociVirusProtein
2008
Evolutionary Genomics of Host Adaptation in Vesicular Stomatitis Virus
Remold SK, Rambaut A, Turner PE. Evolutionary Genomics of Host Adaptation in Vesicular Stomatitis Virus. Molecular Biology And Evolution 2008, 25: 1138-1147. PMID: 18353798, DOI: 10.1093/molbev/msn059.Peer-Reviewed Original ResearchConceptsGenetic architectureComplex traitsHigher fitnessVirus populationsVesicular stomatitis virus populationsParallel phenotypic changesSimilar selection pressuresRNA virus populationsHigh mutation rateEvolutionary genomicsGenome evolutionHost useComplete consensus sequenceTrue pleiotropyHost adaptationAllele substitutionGenomic changesSelection pressureVesicular stomatitis virusConsensus sequenceMutation rateEcological historyPhenotypic changesRNA virusesHeLa cells
2005
Widespread genetic exchange among terrestrial bacteriophages
Silander OK, Weinreich DM, Wright KM, O'Keefe KJ, Rang CU, Turner PE, Chao L. Widespread genetic exchange among terrestrial bacteriophages. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 19009-19014. PMID: 16365305, PMCID: PMC1323146, DOI: 10.1073/pnas.0503074102.Peer-Reviewed Original ResearchConceptsGenetic exchangeLinkage disequilibriumBiological species conceptWidespread genetic exchangeGenomic mutation rateFrequent genetic reassortmentSingle host cellGroup of phagesBiogeography studiesSexual populationsGenetic structureSpecies conceptWild populationsNucleotide divergenceFrequent reassortmentDsRNA genomeBacteriophage populationsDegenerate sitesRecombination eventsNumerical dominanceMutation rateHost cellsGenetic reassortmentUnrelated individualsBacteriophagesEvolution of Mutational Robustness in an RNA Virus
Montville R, Froissart R, Remold SK, Tenaillon O, Turner PE. Evolution of Mutational Robustness in an RNA Virus. PLOS Biology 2005, 3: e381. PMID: 16248678, PMCID: PMC1275523, DOI: 10.1371/journal.pbio.0030381.Peer-Reviewed Original ResearchConceptsMutational robustnessRNA virusesAccurate genome replicationEvolution of robustnessUnderstanding of evolutionAdaptive evolutionGenetic robustnessPopulation bottleneckingPhenotypic constancyMutation accumulationNatural selectionGenetic variationMutational effectsGenome replicationHigh mutation frequencyMutational changesRandom mutationsMutation rateHost cellsBiological populationsFitness changesMutation frequencyGenomeComplementationVirus
2000
The Two Faces of Mutation: Extinction and Adaptation in RNA Viruses
Elena S, Miralles R, Cuevas J, Turner P, Moya A. The Two Faces of Mutation: Extinction and Adaptation in RNA Viruses. IUBMB Life 2000, 49: 5-9. PMID: 10772334, DOI: 10.1080/713803585.Peer-Reviewed Original ResearchConceptsRNA virusesPopulation sizeGenetic variabilityDrastic fitness lossFace of mutationCellular DNA replicationHigh genetic variabilityEffects of mutationsLarge population sizesViral population sizeBottleneck eventsGenetic driftFitness lossDNA replicationFitness gainsSegment exchangeDifferent tissuesViral extinctionReplicative intermediatesInfected hostExtinctionMutationsPopulation standpointHostReplication
1999
Prisoner's dilemma in an RNA virus
Turner P, Chao L. Prisoner's dilemma in an RNA virus. Nature 1999, 398: 441-443. PMID: 10201376, DOI: 10.1038/18913.Peer-Reviewed Original Research