2015
Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells
Foxman EF, Storer JA, Fitzgerald ME, Wasik BR, Hou L, Zhao H, Turner PE, Pyle AM, Iwasaki A. Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 827-832. PMID: 25561542, PMCID: PMC4311828, DOI: 10.1073/pnas.1411030112.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsImmunity, InnateMiceMolecular Sequence DataRhinovirusTemperatureTracheaVirus ReplicationConceptsAirway cellsCommon cold virusViral replicationIFN inductionRecombinant type I IFNMouse airway epithelial cellsCold virusAirway epithelial cellsInduction of ISGsType I IFNPrimary airway cellsCore body temperatureType IAntiviral defense responseLike receptorsI IFNNasal cavityMAVS proteinHuman rhinovirusSustained increaseInnate defensePoly IGenetic deficiencyRobust inductionRhinovirus
2006
Pleiotropic Costs of Niche Expansion in the RNA Bacteriophage Φ6
Duffy S, Turner PE, Burch CL. Pleiotropic Costs of Niche Expansion in the RNA Bacteriophage Φ6. Genetics 2006, 172: 751-757. PMID: 16299384, PMCID: PMC1456241, DOI: 10.1534/genetics.105.051136.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAmino Acid SubstitutionBacteriophage phi 6Epigenesis, GeneticMolecular Sequence DataPseudomonas pseudoalcaligenesPseudomonas syringaeConceptsNiche expansionAntagonistic pleiotropyCosts of generalismVaried ecological conditionsRNA virus phi6Standard laboratory hostRNA bacteriophage φ6Host range mutantsPleiotropic costsHost shiftsPseudomonas hostsFitness costsGenetic basisGenetic dataHost attachmentHost rangeExperimental model systemAdaptive mutationsHost typeNonsynonymous mutationsEcological conditionsOriginal hostRNA virusesBacteriophage Φ6Generalism
2005
Widespread genetic exchange among terrestrial bacteriophages
Silander OK, Weinreich DM, Wright KM, O'Keefe KJ, Rang CU, Turner PE, Chao L. Widespread genetic exchange among terrestrial bacteriophages. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 19009-19014. PMID: 16365305, PMCID: PMC1323146, DOI: 10.1073/pnas.0503074102.Peer-Reviewed Original ResearchConceptsGenetic exchangeLinkage disequilibriumBiological species conceptWidespread genetic exchangeGenomic mutation rateFrequent genetic reassortmentSingle host cellGroup of phagesBiogeography studiesSexual populationsGenetic structureSpecies conceptWild populationsNucleotide divergenceFrequent reassortmentDsRNA genomeBacteriophage populationsDegenerate sitesRecombination eventsNumerical dominanceMutation rateHost cellsGenetic reassortmentUnrelated individualsBacteriophages