2010
ROLE OF EVOLVED HOST BREADTH IN THE INITIAL EMERGENCE OF AN RNA VIRUS
Turner PE, Morales NM, Alto BW, Remold SK. ROLE OF EVOLVED HOST BREADTH IN THE INITIAL EMERGENCE OF AN RNA VIRUS. Evolution 2010, 64: 3273-3286. PMID: 20633045, DOI: 10.1111/j.1558-5646.2010.01051.x.Peer-Reviewed Original ResearchConceptsHost breadthNew hostHost growthPathogen emergenceDirect selectionVesicular stomatitis virus populationsType of selectionHost shiftsPhenotypic plasticityNiche breadthSpecialist virusesHost colonizationIndirect selectionDifferent hostsPopulation varianceRNA virusesPathogen infectiousnessGeneralistsVirus populationsHostEnvironmental robustnessFortuitous changesPopulation growthGrowthVirus
2009
Predicting Virus Evolution: The Relationship between Genetic Robustness and Evolvability of Thermotolerance
Ogbunugafor CB, McBride RC, Turner PE. Predicting Virus Evolution: The Relationship between Genetic Robustness and Evolvability of Thermotolerance. Cold Spring Harbor Symposia On Quantitative Biology 2009, 74: 109-118. PMID: 19843592, DOI: 10.1101/sqb.2009.74.023.Peer-Reviewed Original ResearchConceptsGenetic robustnessVirus evolvabilityMutational inputExtant populationsEvolutionary biologistsEvolutionary eventsExperimental evolutionEvolutionary biologyVirus adaptabilityPhylogenetic methodsAdaptive thermotoleranceVirus evolutionEvolutionary processesHost populationsEvolvabilityPredictive scienceThermotoleranceNew environmentHistorical patternsMicrobesEvolutionBiologistsOrganismsBiologyCanalization
2005
Widespread genetic exchange among terrestrial bacteriophages
Silander OK, Weinreich DM, Wright KM, O'Keefe KJ, Rang CU, Turner PE, Chao L. Widespread genetic exchange among terrestrial bacteriophages. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 19009-19014. PMID: 16365305, PMCID: PMC1323146, DOI: 10.1073/pnas.0503074102.Peer-Reviewed Original ResearchConceptsGenetic exchangeLinkage disequilibriumBiological species conceptWidespread genetic exchangeGenomic mutation rateFrequent genetic reassortmentSingle host cellGroup of phagesBiogeography studiesSexual populationsGenetic structureSpecies conceptWild populationsNucleotide divergenceFrequent reassortmentDsRNA genomeBacteriophage populationsDegenerate sitesRecombination eventsNumerical dominanceMutation rateHost cellsGenetic reassortmentUnrelated individualsBacteriophagesEvolution of Mutational Robustness in an RNA Virus
Montville R, Froissart R, Remold SK, Tenaillon O, Turner PE. Evolution of Mutational Robustness in an RNA Virus. PLOS Biology 2005, 3: e381. PMID: 16248678, PMCID: PMC1275523, DOI: 10.1371/journal.pbio.0030381.Peer-Reviewed Original ResearchConceptsMutational robustnessRNA virusesAccurate genome replicationEvolution of robustnessUnderstanding of evolutionAdaptive evolutionGenetic robustnessPopulation bottleneckingPhenotypic constancyMutation accumulationNatural selectionGenetic variationMutational effectsGenome replicationHigh mutation frequencyMutational changesRandom mutationsMutation rateHost cellsBiological populationsFitness changesMutation frequencyGenomeComplementationVirus
2000
The Two Faces of Mutation: Extinction and Adaptation in RNA Viruses
Elena S, Miralles R, Cuevas J, Turner P, Moya A. The Two Faces of Mutation: Extinction and Adaptation in RNA Viruses. IUBMB Life 2000, 49: 5-9. PMID: 10772334, DOI: 10.1080/713803585.Peer-Reviewed Original ResearchConceptsRNA virusesPopulation sizeGenetic variabilityDrastic fitness lossFace of mutationCellular DNA replicationHigh genetic variabilityEffects of mutationsLarge population sizesViral population sizeBottleneck eventsGenetic driftFitness lossDNA replicationFitness gainsSegment exchangeDifferent tissuesViral extinctionReplicative intermediatesInfected hostExtinctionMutationsPopulation standpointHostReplication