2013
STOCHASTIC TEMPERATURES IMPEDE RNA VIRUS ADAPTATION
Alto BW, Wasik BR, Morales NM, Turner PE. STOCHASTIC TEMPERATURES IMPEDE RNA VIRUS ADAPTATION. Evolution 2013, 67: 969-979. PMID: 23550749, DOI: 10.1111/evo.12034.Peer-Reviewed Original ResearchConceptsFitness gainsVesicular stomatitis virusEvolution of generalistsConvergent molecular evolutionEvolution of specializationCell-binding proteinsMolecular evolutionGenome substitutionsConstant environmentVirus adaptationSequence analysisRNA virusesG geneVirus populationsStomatitis virusMolecular changesLineagesGeneralistsTemperature treatmentKey roleEvolutionGenesLociVirusProtein
2008
Evolutionary Genomics of Host Adaptation in Vesicular Stomatitis Virus
Remold SK, Rambaut A, Turner PE. Evolutionary Genomics of Host Adaptation in Vesicular Stomatitis Virus. Molecular Biology And Evolution 2008, 25: 1138-1147. PMID: 18353798, DOI: 10.1093/molbev/msn059.Peer-Reviewed Original ResearchConceptsGenetic architectureComplex traitsHigher fitnessVirus populationsVesicular stomatitis virus populationsParallel phenotypic changesSimilar selection pressuresRNA virus populationsHigh mutation rateEvolutionary genomicsGenome evolutionHost useComplete consensus sequenceTrue pleiotropyHost adaptationAllele substitutionGenomic changesSelection pressureVesicular stomatitis virusConsensus sequenceMutation rateEcological historyPhenotypic changesRNA virusesHeLa cells
2001
Transmission bottlenecks and the evolution of fitness in rapidly evolving RNA viruses
Elena S, Sanjuán R, Borderı́a A, Turner P. Transmission bottlenecks and the evolution of fitness in rapidly evolving RNA viruses. Infection Genetics And Evolution 2001, 1: 41-48. PMID: 12798049, DOI: 10.1016/s1567-1348(01)00006-5.Peer-Reviewed Original ResearchConceptsVesicular stomatitis virusRNA virusesEvolution of fitnessBasic genetic principlesNatural populationsGenetic driftEvolutionary importanceFitness lossCellular hostsTransmission bottleneckDeleterious mutationsHost individualsGenetic principlesBottleneck sizeViral adaptationViral fitnessStomatitis virusRandom accumulationSimilar bottlenecksTissue cultureMutationsFitnessProfound effectVirusMode of transmission
2000
Cost of Host Radiation in an RNA Virus
Turner P, Elena S. Cost of Host Radiation in an RNA Virus. Genetics 2000, 156: 1465-1470. PMID: 11102349, PMCID: PMC1461356, DOI: 10.1093/genetics/156.4.1465.Peer-Reviewed Original ResearchConceptsHost radiationNovel hostVesicular stomatitis virusOriginal hostHost environmentSubstantial fitness gainsMammalian host cellsNovel habitatsMultiple habitatsEcological nichesExperimental populationsFitness gainsWeak selectionHost typeNew hostGenetic materialHost cellsRNA virusesMultiple host typesReduced competitivenessStomatitis virusHabitatsSlow replicationHostFitness