2024
Experimental Evolution Studies in Φ6 Cystovirus
Singhal S, Balitactac A, Nayagam A, Bahrami P, Nayeem S, Turner P. Experimental Evolution Studies in Φ6 Cystovirus. Viruses 2024, 16: 977. PMID: 38932268, PMCID: PMC11209170, DOI: 10.3390/v16060977.Peer-Reviewed Original ResearchMeSH KeywordsBacteriophage phi 6Biological EvolutionCystoviridaeDirected Molecular EvolutionEvolution, MolecularGenome, ViralHost SpecificityHumansMutationConceptsExperimental evolution studiesFitness effects of spontaneous mutationsSpontaneous mutationsEffects of spontaneous mutationsEvolution of RNA virusesEvolution studiesEvolution of host rangeFast generation timesResponse to selectionMultiple phagesNon-pathogenic modelRNA genomeConsequence of evolutionOuter membraneHost rangeRNA virusesNovel traitsMutation rateHost cellsFitness effectsPopulation sizeMutationsCystovirusesBacteriophageGeneration time
2023
Cheating leads to the evolution of multipartite viruses
Leeks A, Young P, Turner P, Wild G, West S. Cheating leads to the evolution of multipartite viruses. PLOS Biology 2023, 21: e3002092. PMID: 37093882, PMCID: PMC10159356, DOI: 10.1371/journal.pbio.3002092.Peer-Reviewed Original Research
2021
Community context matters for bacteria-phage ecology and evolution
Blazanin M, Turner P. Community context matters for bacteria-phage ecology and evolution. The ISME Journal: Multidisciplinary Journal Of Microbial Ecology 2021, 15: 3119-3128. PMID: 34127803, PMCID: PMC8528888, DOI: 10.1038/s41396-021-01012-x.Peer-Reviewed Original ResearchConceptsBacteria-phage systemsEvolutionary effectsBacteria-phage coevolutionValuable biological modelUnderstanding of bacteriaAdditional bacterial speciesMechanisms of adaptationEcological interactionsPleiotropic consequencesComplex communitiesCoevolutionary dynamicsBacterial speciesEcologyPhagesBacteriaBiological modelsSymbiosesCoevolutionCommunity contextSpeciesEvolutionMultispeciesCommunityAdaptationCommunity presence
2015
Rate of novel host invasion affects adaptability of evolving RNA virus lineages
Morley VJ, Mendiola SY, Turner PE. Rate of novel host invasion affects adaptability of evolving RNA virus lineages. Proceedings Of The Royal Society B 2015, 282: 20150801. PMID: 26246544, PMCID: PMC4632612, DOI: 10.1098/rspb.2015.0801.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, BiologicalBiological EvolutionEnvironmentHost-Pathogen InteractionsSindbis VirusConceptsNovel hostHost cell typesHost invasionCell typesVirus lineagesVirus populationsGenomic outcomesEnvironmental turnoverTissue culture environmentAbility of virusesHost typeRNA virusesConsensus sequencingInfluences adaptationLineagesGradual invasionHostHistorical contingencyMolecular substitutionDifferent genotypesAdaptive changesInvasionRapid shiftVirusSequencing
2012
Selective Pressure Causes an RNA Virus to Trade Reproductive Fitness for Increased Structural and Thermal Stability of a Viral Enzyme
Dessau M, Goldhill D, McBride R, Turner PE, Modis Y. Selective Pressure Causes an RNA Virus to Trade Reproductive Fitness for Increased Structural and Thermal Stability of a Viral Enzyme. PLOS Genetics 2012, 8: e1003102. PMID: 23209446, PMCID: PMC3510033, DOI: 10.1371/journal.pgen.1003102.Peer-Reviewed Original ResearchConceptsFitness tradeoffsPleiotropic mutationMolecular basisRNA virusesSingle amino acid substitutionAmino acid substitutionsIndividual point mutationsEvolutionary tugPleiotropic phenotypesExperimental evolutionAntagonistic pleiotropyEvolutionary biologyProtein functionLytic transglycosylaseNatural selectionProtein P5Reproductive fitnessStructural biologySelective pressureMutational substitutionsHeat shockProtein structureCapsid assemblyAcid substitutionsBacteriophage Φ6
2010
ROLE OF EVOLVED HOST BREADTH IN THE INITIAL EMERGENCE OF AN RNA VIRUS
Turner PE, Morales NM, Alto BW, Remold SK. ROLE OF EVOLVED HOST BREADTH IN THE INITIAL EMERGENCE OF AN RNA VIRUS. Evolution 2010, 64: 3273-3286. PMID: 20633045, DOI: 10.1111/j.1558-5646.2010.01051.x.Peer-Reviewed Original ResearchConceptsHost breadthNew hostHost growthPathogen emergenceDirect selectionVesicular stomatitis virus populationsType of selectionHost shiftsPhenotypic plasticityNiche breadthSpecialist virusesHost colonizationIndirect selectionDifferent hostsPopulation varianceRNA virusesPathogen infectiousnessGeneralistsVirus populationsHostEnvironmental robustnessFortuitous changesPopulation growthGrowthVirus
2009
Predicting Virus Evolution: The Relationship between Genetic Robustness and Evolvability of Thermotolerance
Ogbunugafor CB, McBride RC, Turner PE. Predicting Virus Evolution: The Relationship between Genetic Robustness and Evolvability of Thermotolerance. Cold Spring Harbor Symposia On Quantitative Biology 2009, 74: 109-118. PMID: 19843592, DOI: 10.1101/sqb.2009.74.023.Peer-Reviewed Original ResearchConceptsGenetic robustnessVirus evolvabilityMutational inputExtant populationsEvolutionary biologistsEvolutionary eventsExperimental evolutionEvolutionary biologyVirus adaptabilityPhylogenetic methodsAdaptive thermotoleranceVirus evolutionEvolutionary processesHost populationsEvolvabilityPredictive scienceThermotoleranceNew environmentHistorical patternsMicrobesEvolutionBiologistsOrganismsBiologyCanalization
2007
EVOLUTION OF HOST SPECIFICITY DRIVES REPRODUCTIVE ISOLATION AMONG RNA VIRUSES
Duffy S, Burch CL, Turner PE. EVOLUTION OF HOST SPECIFICITY DRIVES REPRODUCTIVE ISOLATION AMONG RNA VIRUSES. Evolution 2007, 61: 2614-2622. PMID: 17908251, PMCID: PMC7202233, DOI: 10.1111/j.1558-5646.2007.00226.x.Peer-Reviewed Original ResearchConceptsReproductive isolationEcological speciation hypothesisDivergent natural selectionRNA virusesAssortative mating evolvesNatural selectionHost rangeRNA bacteriophage phi6Speciation hypothesisSingle nucleotide changePhytophagous insectsEcological adaptationNovel hostEvolutionary fateWhole-genome sequencingGenetic exchangeImportant traitsBiological credibilityAlternative hostsExperimental populationsLaboratory populationsAssortative matingDirect selectionGenome sequencingNucleotide changesVirus population extinction via ecological traps
Dennehy JJ, Friedenberg NA, Yang YW, Turner PE. Virus population extinction via ecological traps. Ecology Letters 2007, 10: 230-240. PMID: 17305806, DOI: 10.1111/j.1461-0248.2006.01013.x.Peer-Reviewed Original ResearchMeSH KeywordsBiological EvolutionEcologyHumansModels, TheoreticalPopulation DynamicsRNA PhagesVirus DiseasesVirusesConceptsEcological trapsPopulation growthHigh-quality habitatRisk of extinctionHeterogeneous host communitiesNet population growthHabitat lossSpecies conservationPopulation viabilityMetapopulation scaleInfectious human virusesRNA bacteriophage phi6Population extinctionEcological conceptsEfficacy of trapsHabitatsHost bacteriaHost cellsExtinctionTrap cellsBacteriophage phi6Host communitiesViral reproductionVirus populationsViral fitness
2005
Evolution of Mutational Robustness in an RNA Virus
Montville R, Froissart R, Remold SK, Tenaillon O, Turner PE. Evolution of Mutational Robustness in an RNA Virus. PLOS Biology 2005, 3: e381. PMID: 16248678, PMCID: PMC1275523, DOI: 10.1371/journal.pbio.0030381.Peer-Reviewed Original ResearchConceptsMutational robustnessRNA virusesAccurate genome replicationEvolution of robustnessUnderstanding of evolutionAdaptive evolutionGenetic robustnessPopulation bottleneckingPhenotypic constancyMutation accumulationNatural selectionGenetic variationMutational effectsGenome replicationHigh mutation frequencyMutational changesRandom mutationsMutation rateHost cellsBiological populationsFitness changesMutation frequencyGenomeComplementationVirus
2004
Reduced fecundity is the cost of cheating in RNA virus 6
Dennehy J, Turner P. Reduced fecundity is the cost of cheating in RNA virus 6. Proceedings Of The Royal Society B 2004, 271: 2275-2282. PMID: 15539353, PMCID: PMC1691856, DOI: 10.1098/rspb.2004.2833.Peer-Reviewed Original ResearchConceptsHost fitnessTiming of reproductionRNA bacteriophage phi6Costs of cheatingLytic growth cycleSmall burst sizeDispersal stageInterference competitionLifetime fecundityIntracellular resourcesLife historyHigher fitnessEvolved virusesReduced fecunditySolo infectionsBacteriophage phi6FecundityLytic infectionGrowth cycleAncestorBurst sizeFitnessLatent periodCheatersMultiple viruses
2000
Cost of Host Radiation in an RNA Virus
Turner P, Elena S. Cost of Host Radiation in an RNA Virus. Genetics 2000, 156: 1465-1470. PMID: 11102349, PMCID: PMC1461356, DOI: 10.1093/genetics/156.4.1465.Peer-Reviewed Original ResearchConceptsHost radiationNovel hostVesicular stomatitis virusOriginal hostHost environmentSubstantial fitness gainsMammalian host cellsNovel habitatsMultiple habitatsEcological nichesExperimental populationsFitness gainsWeak selectionHost typeNew hostGenetic materialHost cellsRNA virusesMultiple host typesReduced competitivenessStomatitis virusHabitatsSlow replicationHostFitness
1999
Prisoner's dilemma in an RNA virus
Turner P, Chao L. Prisoner's dilemma in an RNA virus. Nature 1999, 398: 441-443. PMID: 10201376, DOI: 10.1038/18913.Peer-Reviewed Original ResearchMeSH KeywordsBacteriophage phi 6Biological EvolutionGame TheoryModels, BiologicalMutationVirus Replication
1998
Sex and the Evolution of Intrahost Competition in RNA Virus φ6
Turner P, Chao L. Sex and the Evolution of Intrahost Competition in RNA Virus φ6. Genetics 1998, 150: 523-532. PMID: 9755186, PMCID: PMC1460345, DOI: 10.1093/genetics/150.2.523.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalBacteriophage phi 6Biological EvolutionPseudomonasReproductionSexConceptsIntrahost competitionLarge sexual populationsLarge asexual populationsRNA virus phi6Absence of sexSame host cellRate of adaptationSexual populationsGenetic conflictSexual reproductionAsexual populationsMore rapid adaptationBeneficial mutationsSame genomeSeparate lineagesExperimental populationsBacterial hostsMultiple bacteriophagesAbility of virusesHost cellsRNA virusesRapid adaptationPseudomonas phaseolicolaPhi6Host