2016
Generalized selection to overcome innate immunity selects for host breadth in an RNA virus
Wasik BR, Muñoz‐Rojas A, Okamoto KW, Miller‐Jensen K, Turner PE. Generalized selection to overcome innate immunity selects for host breadth in an RNA virus. Evolution 2016, 70: 270-281. PMID: 26882316, DOI: 10.1111/evo.12845.Peer-Reviewed Original ResearchConceptsVesicular stomatitis virus populationsInnate immunityRNA virusesHost cell levelVirus-host coevolutionDifferent species originViral fitnessCompetent cellsVSV populationsHost breadthHuman cancer cellsEvolutionary historyFitness differencesHost speciesDisparate hostsSpecies originInfection successInnate immune capacityPrimate cellsInnate immune functionVirus populationsImmune deficient cellsEmergence potentialImmune competent cellsNonhuman primate cells
2010
ROLE OF EVOLVED HOST BREADTH IN THE INITIAL EMERGENCE OF AN RNA VIRUS
Turner PE, Morales NM, Alto BW, Remold SK. ROLE OF EVOLVED HOST BREADTH IN THE INITIAL EMERGENCE OF AN RNA VIRUS. Evolution 2010, 64: 3273-3286. PMID: 20633045, DOI: 10.1111/j.1558-5646.2010.01051.x.Peer-Reviewed Original ResearchConceptsHost breadthNew hostHost growthPathogen emergenceDirect selectionVesicular stomatitis virus populationsType of selectionHost shiftsPhenotypic plasticityNiche breadthSpecialist virusesHost colonizationIndirect selectionDifferent hostsPopulation varianceRNA virusesPathogen infectiousnessGeneralistsVirus populationsHostEnvironmental robustnessFortuitous changesPopulation growthGrowthVirus
2008
Evolutionary Genomics of Host Adaptation in Vesicular Stomatitis Virus
Remold SK, Rambaut A, Turner PE. Evolutionary Genomics of Host Adaptation in Vesicular Stomatitis Virus. Molecular Biology And Evolution 2008, 25: 1138-1147. PMID: 18353798, DOI: 10.1093/molbev/msn059.Peer-Reviewed Original ResearchConceptsGenetic architectureComplex traitsHigher fitnessVirus populationsVesicular stomatitis virus populationsParallel phenotypic changesSimilar selection pressuresRNA virus populationsHigh mutation rateEvolutionary genomicsGenome evolutionHost useComplete consensus sequenceTrue pleiotropyHost adaptationAllele substitutionGenomic changesSelection pressureVesicular stomatitis virusConsensus sequenceMutation rateEcological historyPhenotypic changesRNA virusesHeLa cells
2000
Cost of Host Radiation in an RNA Virus
Turner P, Elena S. Cost of Host Radiation in an RNA Virus. Genetics 2000, 156: 1465-1470. PMID: 11102349, PMCID: PMC1461356, DOI: 10.1093/genetics/156.4.1465.Peer-Reviewed Original ResearchConceptsHost radiationNovel hostVesicular stomatitis virusOriginal hostHost environmentSubstantial fitness gainsMammalian host cellsNovel habitatsMultiple habitatsEcological nichesExperimental populationsFitness gainsWeak selectionHost typeNew hostGenetic materialHost cellsRNA virusesMultiple host typesReduced competitivenessStomatitis virusHabitatsSlow replicationHostFitness