Generalized selection to overcome innate immunity selects for host breadth in an RNA virus
Wasik BR, Muñoz‐Rojas A, Okamoto KW, Miller‐Jensen K, Turner PE. Generalized selection to overcome innate immunity selects for host breadth in an RNA virus. Evolution 2016, 70: 270-281. PMID: 26882316, DOI: 10.1111/evo.12845.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDogsEvolution, MolecularHeLa CellsHost SpecificityHumansImmunity, InnateMadin Darby Canine Kidney CellsSelection, GeneticVesiculovirusConceptsVesicular stomatitis virus populationsInnate immunityRNA virusesHost cell levelVirus-host coevolutionDifferent species originViral fitnessCompetent cellsVSV populationsHost breadthHuman cancer cellsEvolutionary historyFitness differencesHost speciesDisparate hostsSpecies originInfection successInnate immune capacityPrimate cellsInnate immune functionVirus populationsImmune deficient cellsEmergence potentialImmune competent cellsNonhuman primate cells