Selective Pressure Causes an RNA Virus to Trade Reproductive Fitness for Increased Structural and Thermal Stability of a Viral Enzyme
Dessau M, Goldhill D, McBride R, Turner PE, Modis Y. Selective Pressure Causes an RNA Virus to Trade Reproductive Fitness for Increased Structural and Thermal Stability of a Viral Enzyme. PLOS Genetics 2012, 8: e1003102. PMID: 23209446, PMCID: PMC3510033, DOI: 10.1371/journal.pgen.1003102.Peer-Reviewed Original ResearchConceptsFitness tradeoffsPleiotropic mutationMolecular basisRNA virusesSingle amino acid substitutionAmino acid substitutionsIndividual point mutationsEvolutionary tugPleiotropic phenotypesExperimental evolutionAntagonistic pleiotropyEvolutionary biologyProtein functionLytic transglycosylaseNatural selectionProtein P5Reproductive fitnessStructural biologySelective pressureMutational substitutionsHeat shockProtein structureCapsid assemblyAcid substitutionsBacteriophage Φ6