2015
Rate of novel host invasion affects adaptability of evolving RNA virus lineages
Morley VJ, Mendiola SY, Turner PE. Rate of novel host invasion affects adaptability of evolving RNA virus lineages. Proceedings Of The Royal Society B 2015, 282: 20150801. PMID: 26246544, PMCID: PMC4632612, DOI: 10.1098/rspb.2015.0801.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, BiologicalBiological EvolutionEnvironmentHost-Pathogen InteractionsSindbis VirusConceptsNovel hostHost cell typesHost invasionCell typesVirus lineagesVirus populationsGenomic outcomesEnvironmental turnoverTissue culture environmentAbility of virusesHost typeRNA virusesConsensus sequencingInfluences adaptationLineagesGradual invasionHostHistorical contingencyMolecular substitutionDifferent genotypesAdaptive changesInvasionRapid shiftVirusSequencing
2008
Robustness promotes evolvability of thermotolerance in an RNA virus
McBride RC, Ogbunugafor CB, Turner PE. Robustness promotes evolvability of thermotolerance in an RNA virus. BMC Ecology And Evolution 2008, 8: 231. PMID: 18694497, PMCID: PMC2518931, DOI: 10.1186/1471-2148-8-231.Peer-Reviewed Original ResearchConceptsGenetic robustnessEfficacy of selectionNew habitatsEvolutionary biologyVirus adaptabilityLaboratory populationsMutational changesNew nichesEvolvabilityRNA virusesFace of perturbationsGreater toleranceThermotoleranceRobust clonesNovel environmentClonesBiological systemsBalance of robustnessFuture adaptationUnderlying mechanismHabitatsNicheBiologyGreater resistancePopulationEvolutionary Genomics of Host Adaptation in Vesicular Stomatitis Virus
Remold SK, Rambaut A, Turner PE. Evolutionary Genomics of Host Adaptation in Vesicular Stomatitis Virus. Molecular Biology And Evolution 2008, 25: 1138-1147. PMID: 18353798, DOI: 10.1093/molbev/msn059.Peer-Reviewed Original ResearchConceptsGenetic architectureComplex traitsHigher fitnessVirus populationsVesicular stomatitis virus populationsParallel phenotypic changesSimilar selection pressuresRNA virus populationsHigh mutation rateEvolutionary genomicsGenome evolutionHost useComplete consensus sequenceTrue pleiotropyHost adaptationAllele substitutionGenomic changesSelection pressureVesicular stomatitis virusConsensus sequenceMutation rateEcological historyPhenotypic changesRNA virusesHeLa cells
2006
Viral ecology and the maintenance of novel host use.
Dennehy JJ, Friedenberg NA, Holt RD, Turner PE. Viral ecology and the maintenance of novel host use. The American Naturalist 2006, 167: 429-39. PMID: 16673350, DOI: 10.1086/499381.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, BiologicalBacteriophage phi 6Coculture TechniquesEcosystemPopulation DynamicsPseudomonas pseudoalcaligenesPseudomonas syringaeVirus CultivationConceptsNovel hostHost useNative hostNovel host useNew host speciesHost population growthPhage growth rateGenetic adaptationViral ecologyHost speciesSerial passage experimentsPopulation dynamicsHost bacteriaRNA phagesVirus extinctionHost transmissionViral populationsVirus populationsHostPassage experimentsSpeciesGrowth ratePopulation growthAdaptationEcology