2020
Experimental Evolution of Human Rhinovirus Strains Adapting to Mouse Cells
Wasik B, Wasik B, Foxman E, Iwasaki A, Turner P. Experimental Evolution of Human Rhinovirus Strains Adapting to Mouse Cells. Genetic And Evolutionary Computation 2020, 145-157. DOI: 10.1007/978-3-030-39831-6_12.Peer-Reviewed Original ResearchMouse cellsIdentical selection pressuresExperimental evolution studiesLaboratory tissue cultureCommon cold illnessesViral capsid geneMolecular divergenceExperimental evolutionReplication genesSelection pressureRelated populationsGenetic changesRNA virusesHuman rhinovirus strainsCapsid geneEvolution studiesRV-1BInnate immunityGenesTissue cultureDifferent strainsCellsLA-4 cellsHostMouse host
2001
Transmission bottlenecks and the evolution of fitness in rapidly evolving RNA viruses
Elena S, Sanjuán R, Borderı́a A, Turner P. Transmission bottlenecks and the evolution of fitness in rapidly evolving RNA viruses. Infection Genetics And Evolution 2001, 1: 41-48. PMID: 12798049, DOI: 10.1016/s1567-1348(01)00006-5.Peer-Reviewed Original ResearchConceptsVesicular stomatitis virusRNA virusesEvolution of fitnessBasic genetic principlesNatural populationsGenetic driftEvolutionary importanceFitness lossCellular hostsTransmission bottleneckDeleterious mutationsHost individualsGenetic principlesBottleneck sizeViral adaptationViral fitnessStomatitis virusRandom accumulationSimilar bottlenecksTissue cultureMutationsFitnessProfound effectVirusMode of transmission