2009
Predicting Virus Evolution: The Relationship between Genetic Robustness and Evolvability of Thermotolerance
Ogbunugafor CB, McBride RC, Turner PE. Predicting Virus Evolution: The Relationship between Genetic Robustness and Evolvability of Thermotolerance. Cold Spring Harbor Symposia On Quantitative Biology 2009, 74: 109-118. PMID: 19843592, DOI: 10.1101/sqb.2009.74.023.Peer-Reviewed Original ResearchConceptsGenetic robustnessVirus evolvabilityMutational inputExtant populationsEvolutionary biologistsEvolutionary eventsExperimental evolutionEvolutionary biologyVirus adaptabilityPhylogenetic methodsAdaptive thermotoleranceVirus evolutionEvolutionary processesHost populationsEvolvabilityPredictive scienceThermotoleranceNew environmentHistorical patternsMicrobesEvolutionBiologistsOrganismsBiologyCanalization
2008
Robustness promotes evolvability of thermotolerance in an RNA virus
McBride RC, Ogbunugafor CB, Turner PE. Robustness promotes evolvability of thermotolerance in an RNA virus. BMC Ecology And Evolution 2008, 8: 231. PMID: 18694497, PMCID: PMC2518931, DOI: 10.1186/1471-2148-8-231.Peer-Reviewed Original ResearchConceptsGenetic robustnessEfficacy of selectionNew habitatsEvolutionary biologyVirus adaptabilityLaboratory populationsMutational changesNew nichesEvolvabilityRNA virusesFace of perturbationsGreater toleranceThermotoleranceRobust clonesNovel environmentClonesBiological systemsBalance of robustnessFuture adaptationUnderlying mechanismHabitatsNicheBiologyGreater resistancePopulation
2005
Evolution of Mutational Robustness in an RNA Virus
Montville R, Froissart R, Remold SK, Tenaillon O, Turner PE. Evolution of Mutational Robustness in an RNA Virus. PLOS Biology 2005, 3: e381. PMID: 16248678, PMCID: PMC1275523, DOI: 10.1371/journal.pbio.0030381.Peer-Reviewed Original ResearchConceptsMutational robustnessRNA virusesAccurate genome replicationEvolution of robustnessUnderstanding of evolutionAdaptive evolutionGenetic robustnessPopulation bottleneckingPhenotypic constancyMutation accumulationNatural selectionGenetic variationMutational effectsGenome replicationHigh mutation frequencyMutational changesRandom mutationsMutation rateHost cellsBiological populationsFitness changesMutation frequencyGenomeComplementationVirus