2012
Selective Pressure Causes an RNA Virus to Trade Reproductive Fitness for Increased Structural and Thermal Stability of a Viral Enzyme
Dessau M, Goldhill D, McBride R, Turner PE, Modis Y. Selective Pressure Causes an RNA Virus to Trade Reproductive Fitness for Increased Structural and Thermal Stability of a Viral Enzyme. PLOS Genetics 2012, 8: e1003102. PMID: 23209446, PMCID: PMC3510033, DOI: 10.1371/journal.pgen.1003102.Peer-Reviewed Original ResearchConceptsFitness tradeoffsPleiotropic mutationMolecular basisRNA virusesSingle amino acid substitutionAmino acid substitutionsIndividual point mutationsEvolutionary tugPleiotropic phenotypesExperimental evolutionAntagonistic pleiotropyEvolutionary biologyProtein functionLytic transglycosylaseNatural selectionProtein P5Reproductive fitnessStructural biologySelective pressureMutational substitutionsHeat shockProtein structureCapsid assemblyAcid substitutionsBacteriophage Φ6
2009
Predicting Virus Evolution: The Relationship between Genetic Robustness and Evolvability of Thermotolerance
Ogbunugafor CB, McBride RC, Turner PE. Predicting Virus Evolution: The Relationship between Genetic Robustness and Evolvability of Thermotolerance. Cold Spring Harbor Symposia On Quantitative Biology 2009, 74: 109-118. PMID: 19843592, DOI: 10.1101/sqb.2009.74.023.Peer-Reviewed Original ResearchConceptsGenetic robustnessVirus evolvabilityMutational inputExtant populationsEvolutionary biologistsEvolutionary eventsExperimental evolutionEvolutionary biologyVirus adaptabilityPhylogenetic methodsAdaptive thermotoleranceVirus evolutionEvolutionary processesHost populationsEvolvabilityPredictive scienceThermotoleranceNew environmentHistorical patternsMicrobesEvolutionBiologistsOrganismsBiologyCanalization
2008
Robustness promotes evolvability of thermotolerance in an RNA virus
McBride RC, Ogbunugafor CB, Turner PE. Robustness promotes evolvability of thermotolerance in an RNA virus. BMC Ecology And Evolution 2008, 8: 231. PMID: 18694497, PMCID: PMC2518931, DOI: 10.1186/1471-2148-8-231.Peer-Reviewed Original ResearchConceptsGenetic robustnessEfficacy of selectionNew habitatsEvolutionary biologyVirus adaptabilityLaboratory populationsMutational changesNew nichesEvolvabilityRNA virusesFace of perturbationsGreater toleranceThermotoleranceRobust clonesNovel environmentClonesBiological systemsBalance of robustnessFuture adaptationUnderlying mechanismHabitatsNicheBiologyGreater resistancePopulationEvolutionary ecology of multiple phage adsorption and infection
Turner P, Duffy S. Evolutionary ecology of multiple phage adsorption and infection. 2008, 195-216. DOI: 10.1017/cbo9780511541483.011.Peer-Reviewed Original ResearchEvolutionary ecologyInterface of ecologyHost cell machineryPhage adsorptionEvolutionary responsesGenetic exchangePhage genesEvolutionary biologyCell machineryPhage populationsIncredible diversityHost competitionSelective pressureEvolutionary standpointUnrelated phagesSuperinfection exclusionIndividual bacteriaEcological effectsSame hostEcologyGenetic variantsHigher phage densitiesPhagesPhage densitiesIndividual phagesPhage evolutionary biology
Duffy S, Turner P. Phage evolutionary biology. 2008, 147-176. DOI: 10.1017/cbo9780511541483.009.Peer-Reviewed Original ResearchEvolutionary biologyEvolutionary biologistsAge of genomicsEcological radiationEvolutionary geneticistsWild populationsMolecular researchersMolecular revolutionPhage biologistsMolecular biologyBiologyMicrobial experimentsEcologyBiologistsMicrobesReductionist approachBiology DepartmentBiological truthGenomicsSignificant discoveriesBiodiversityMicrobiologistsMolecular sideDiscoveryMicrobiology