2001
Genetics of Central Nervous System Developmental Disorders
Naegele J, Lombroso P. Genetics of Central Nervous System Developmental Disorders. Child And Adolescent Psychiatric Clinics Of North America 2001, 10: 225-239. PMID: 11351796, DOI: 10.1016/s1056-4993(18)30055-5.Peer-Reviewed Original Research
1998
Molecular mechanisms of developmental disorders
BRODSKY M, LOMBROSO P. Molecular mechanisms of developmental disorders. Development And Psychopathology 1998, 10: 1-20. PMID: 9524805, DOI: 10.1017/s0954579498001503.Peer-Reviewed Original ResearchConceptsPutative genesFragile X syndromeGenetic mechanismsMolecular mechanismsComplex behavioral disordersX syndromeDevelopmental disordersCertain developmental disordersGenesPathological conditionsGenetic factorsPrader-Willi syndromeNormal functioningRecent scientific advancesMolecular findingsConsiderable progressMechanismMutationsBetter understandingExpressionLissencephalyUnderstanding
1995
Identification of two alternatively spliced transcripts of STEP: a subfamily of brain-enriched protein tyrosine phosphatases
Sharma E, Zhao F, Bult A, Lombroso P. Identification of two alternatively spliced transcripts of STEP: a subfamily of brain-enriched protein tyrosine phosphatases. Brain Research 1995, 32: 87-93. PMID: 7494467, DOI: 10.1016/0169-328x(95)00066-2.Peer-Reviewed Original ResearchConceptsTyrosine phosphatase domainPhosphatase domainProtein tyrosineSpliced transcriptsExon-intron organizationProtein tyrosine phosphataseOpen reading frameTyrosine phosphataseReading frameDistinct functionsGenomic DNANorthern analysisSTEP geneSTEP isoformsMolecular massTranscriptsSTEP61ProteinMouse brainTyrosineCentral nervous systemSubfamiliesGenesNervous systemMonoclonal antibodies
1991
Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum.
Lombroso P, Murdoch G, Lerner M. Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 7242-7246. PMID: 1714595, PMCID: PMC52270, DOI: 10.1073/pnas.88.16.7242.Peer-Reviewed Original ResearchConceptsDeduced amino acid sequenceAmino acid consensus sequenceAmino acid sequenceApparent molecular massRat striatal cDNA librarySingle geneVitro translationCDNA clonesStrong homologyCDNA libraryCytoplasmic membraneAcid sequenceRNA transcriptsN-terminusMolecular characterizationRNA analysisMolecular massAmino acidsProteinPhosphataseMRNASequenceHomologyGenesTerminus