2018
Perioperative pulmonary thromboembolism
Ruohoniemi DM, Sista AK, Doany CF, Heerdt PM. Perioperative pulmonary thromboembolism. Current Opinion In Anaesthesiology 2018, 31: 75-82. PMID: 29206697, DOI: 10.1097/aco.0000000000000550.Peer-Reviewed Original ResearchConceptsSubmassive pulmonary emboliCatheter-directed therapyPulmonary emboliSystemic anticoagulationIntervention efficacyMean pulmonary artery pressurePerioperative pulmonary thromboembolismPulmonary artery pressureCurrent treatment optionsWarrants further investigationInadequacy of treatmentArtery pressurePulmonary thromboembolismPostoperative patientsPulmonary embolismRelative contraindicationSurgical patientsAggressive interventionIntraoperative embolizationPerioperative patientsTreatment optionsOptimizing therapyPromising efficacyElevated riskVentricular monitoring
2012
Transcriptomic analysis reveals atrial KCNE1 down‐regulation following lung lobectomy
Heerdt PM, Kant R, Hu Z, Kanda VA, Christini DJ, Malhotra JK, Abbott GW. Transcriptomic analysis reveals atrial KCNE1 down‐regulation following lung lobectomy. Journal Of Molecular And Cellular Cardiology 2012, 53: 350-353. PMID: 22641150, PMCID: PMC3418454, DOI: 10.1016/j.yjmcc.2012.05.010.Peer-Reviewed Original ResearchConceptsEffective refractory periodLone atrial fibrillationAtrial fibrillationPostoperative AFLung lobectomyLeft atriumNew-onset postoperative atrial fibrillationMean pulmonary artery pressurePostoperative atrial fibrillationPulmonary vascular resistanceUpper lung lobectomyPulmonary artery pressureTelemetric ECGArtery pressureVascular resistanceMajor surgeryHemodynamic variablesFunction polymorphismLA tissuesRefractory periodWestern blottingProtein levelsGene sequence variantsMolecular changesLobectomy
2010
Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs
Heerdt PM, Malhotra JK, Pan BY, Sunaga H, Savarese JJ. Pharmacodynamics and Cardiopulmonary Side Effects of CW002, a Cysteine-reversible Neuromuscular Blocking Drug in Dogs. Anesthesiology 2010, 112: 910-916. PMID: 20234311, DOI: 10.1097/aln.0b013e3181d31f71.Peer-Reviewed Original ResearchConceptsX ED95Neuromuscular blocking drugsCardiopulmonary side effectsVascular resistanceArterial pressureBlocking drugsCardiac outputHistamine releaseSide effectsMean pulmonary artery pressurePulmonary artery pressurePulmonary vascular resistanceSystemic vascular resistanceMean arterial pressurePulmonary arterial pressureArtery pressureHemodynamic effectsPulmonary complianceVentricular contractilityInspiratory pressureNeuromuscular blockadeVentricular pressureED95Large dosesCW002