2020
Validating Self‐Reported Unhealthy Alcohol Use With Phosphatidylethanol (PEth) Among Patients With HIV
Eyawo O, Deng Y, Dziura J, Justice AC, McGinnis K, Tate JP, Rodriguez‐Barradas M, Hansen NB, Maisto SA, Marconi VC, O’Connor P, Bryant K, Fiellin DA, Edelman EJ. Validating Self‐Reported Unhealthy Alcohol Use With Phosphatidylethanol (PEth) Among Patients With HIV. Alcohol Clinical And Experimental Research 2020, 44: 2053-2063. PMID: 33460225, PMCID: PMC8856627, DOI: 10.1111/acer.14435.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useSignificant alcohol useHeavy drinking daysAlcohol use disorderTimeline FollowbackAlcohol useSelf-reported alcohol useNumber of drinksClinical trialsRisk drinkingUse disordersDrinking daysBiomarker-based evidenceSample of PWHDrinks/dayMean numberSelf-reported alcohol consumptionMagnitude of associationBlood spot samplesLiver diseasePEth levelsTLFB interviewAlcohol consumptionLogistic regressionPatientsIntegrated stepped alcohol treatment for patients with HIV and at-risk alcohol use: a randomized trial
Edelman EJ, Maisto SA, Hansen NB, Cutter CJ, Dziura J, Deng Y, Fiellin LE, O’Connor P, Bedimo R, Gibert CL, Marconi VC, Rimland D, Rodriguez-Barradas MC, Simberkoff MS, Tate JP, Justice AC, Bryant KJ, Fiellin DA. Integrated stepped alcohol treatment for patients with HIV and at-risk alcohol use: a randomized trial. Addiction Science & Clinical Practice 2020, 15: 28. PMID: 32727618, PMCID: PMC7388231, DOI: 10.1186/s13722-020-00200-y.Peer-Reviewed Original ResearchConceptsRisk alcohol useAlcohol useAlcohol treatmentHealth of patientsEvidence-based strategiesWeek 24HIV outcomesRoutine careTelephone boosterPhysician managementEnhancement therapyHIVPWHPatientsTrialsTarget populationTreatmentAlcohol-related researchMulti-pronged approachOutcomesParticipantsInsufficient numberTherapyPopulationMethodsIn
2019
Integrated stepped alcohol treatment for patients with HIV and liver disease: A randomized trial
Edelman EJ, Maisto SA, Hansen NB, Cutter CJ, Dziura J, Deng Y, Fiellin LE, O'Connor PG, Bedimo R, Gibert CL, Marconi VC, Rimland D, Rodriguez-Barradas MC, Simberkoff MS, Tate JP, Justice AC, Bryant KJ, Fiellin DA. Integrated stepped alcohol treatment for patients with HIV and liver disease: A randomized trial. Journal Of Substance Use And Addiction Treatment 2019, 106: 97-106. PMID: 31540617, PMCID: PMC7244228, DOI: 10.1016/j.jsat.2019.08.007.Peer-Reviewed Original ResearchIntegrated stepped alcohol treatment for patients with HIV and alcohol use disorder: a randomised controlled trial
Edelman EJ, Maisto SA, Hansen NB, Cutter CJ, Dziura J, Deng Y, Fiellin LE, O'Connor PG, Bedimo R, Gibert CL, Marconi VC, Rimland D, Rodriguez-Barradas MC, Simberkoff MS, Tate JP, Justice AC, Bryant KJ, Fiellin DA. Integrated stepped alcohol treatment for patients with HIV and alcohol use disorder: a randomised controlled trial. The Lancet HIV 2019, 6: e509-e517. PMID: 31109915, PMCID: PMC7161741, DOI: 10.1016/s2352-3018(19)30076-1.Peer-Reviewed Original ResearchConceptsAlcohol use disorderWeek 24Use disordersAlcohol treatmentAdverse eventsNumber of drinksTreatment medicationsPhysician managementAlcohol abuseMental Disorders-IV criteriaAlcohol-related careFormal alcohol treatmentKey exclusion criteriaTimeline followback methodMotivational enhancement therapyTreat populationHIV clinicHIV outcomesPrimary outcomeSpecialty referralsMean ageUS National InstitutesWeek 4Medical conditionsExclusion criteria
2010
The Safety of Opioid Analgesics in the Elderly: New Data Raise New Concerns: Comment on “The Comparative Safety of Opioids for Nonmalignant Pain in Older Adults”
Becker WC, O'Connor PG. The Safety of Opioid Analgesics in the Elderly: New Data Raise New Concerns: Comment on “The Comparative Safety of Opioids for Nonmalignant Pain in Older Adults”. JAMA Internal Medicine 2010, 170: 1986-1988. PMID: 21149755, DOI: 10.1001/archinternmed.2010.443.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalCardiovascular DiseasesComorbidityContraindicationsCyclooxygenase 2 InhibitorsDrug UtilizationFemaleFractures, BoneGastrointestinal HemorrhageHumansMaleMedicareObservationPainPain MeasurementResearch DesignTherapeutic EquivalencyUnited States
2006
A Randomized Trial of Primary Intensive Care to Reduce Hospital Admissions in Patients with High Utilization of Inpatient Services
Sledge WH, Brown KE, Levine JM, Fiellin DA, Chawarski M, White WD, O'Connor PG. A Randomized Trial of Primary Intensive Care to Reduce Hospital Admissions in Patients with High Utilization of Inpatient Services. Population Health Management 2006, 9: 328-338. PMID: 17115880, DOI: 10.1089/dis.2006.9.328.Peer-Reviewed Original ResearchConceptsHospital admissionIntensive careFunctional statusInpatient servicesHealth outcomesUrban primary care clinicFrequent hospital admissionsEmergency department visitsMedication Adherence ScalePrimary care patientsPrimary care clinicsHealth care useRandomized clinical trialsOverall functional statusCase management interventionComprehensive multidisciplinary assessmentNumber of admissionsMental health functionPIC patientsUsual careClinic visitsCare patientsControlled TrialsDepartment visitsCare clinicsHigh Rate of Negative Results of Tuberculin and QuantiFERON Tests Among Individuals With a History of Positive Skin Test Results
Friedman LN, Nash ER, Bryant J, Henry S, Shi J, D'Amato J, Khaled GH, Russi MB, O'Connor PG, Edberg SC, Pisani MA, Cain HC, Tanoue L, Weissman DN. High Rate of Negative Results of Tuberculin and QuantiFERON Tests Among Individuals With a History of Positive Skin Test Results. Infection Control And Hospital Epidemiology 2006, 27: 436-441. PMID: 16671022, DOI: 10.1086/503690.Peer-Reviewed Original ResearchConceptsQuantiFERON-TB testTuberculin skin testPrevious tuberculin skin testTST statusInitial tuberculin skin testPositive tuberculin skin testSecond tuberculin skin testPositive skin test resultsExperienced healthcare workersNegative TST resultsTST-negative groupSkin test resultsTST protocolWhole blood assaysNegative resultsPositive resultsTuberculosis exposureImmunocompetent subjectsQuantiFERON testSkin testTST resultsMedical recordsInduration diameterHealthcare workersHigh riskAre Commonly Ordered Lab Tests Useful Screens for Alcohol Disorders in Older Male Veterans Receiving Primary Care?
Reid MC, Guo Z, Van Ness PH, O'Connor PG, Concato J. Are Commonly Ordered Lab Tests Useful Screens for Alcohol Disorders in Older Male Veterans Receiving Primary Care? Substance Abuse 2006, 26: 25-32. PMID: 16687367, DOI: 10.1300/j465v26n02_04.Peer-Reviewed Original ResearchConceptsAST/ALT ratioAlcohol abuse/dependenceMean corpuscular volumeOlder male veteransAbuse/dependenceAlcohol Use Disorders Identification TestCAGE positivityRisk drinkingAlanine aminotransferaseALT ratioAspartate aminotransferaseAlcohol disordersMale veteransPrimary careMedical recordsParticipants' medical recordsAbnormal test resultsTest performance characteristicsDisorders Identification TestPositive likelihood ratioNegative likelihood ratioLikelihood ratioRoutine careVA databasesCAGE questionnaireQuality of Care for Acute Myocardial Infarction in Elderly Patients with Alcohol‐Related Diagnoses
Fiellin DA, O'Connor PG, Wang Y, Radford MJ, Krumholz HM. Quality of Care for Acute Myocardial Infarction in Elderly Patients with Alcohol‐Related Diagnoses. Alcohol Clinical And Experimental Research 2006, 30: 70-75. PMID: 16433733, DOI: 10.1111/j.1530-0277.2006.00001.x.Peer-Reviewed Original ResearchConceptsAlcohol-related diagnosesAcute myocardial infarctionMyocardial infarctionElderly patientsEligible patientsCare measuresRetrospective cohort analysisPrincipal discharge diagnosisTime of dischargeCooperative Cardiovascular ProjectAcute care hospitalsMedical record dataQuality of careBaseline characteristicsCare hospitalPrimary outcomeDischarge diagnosisCohort analysisAlcohol abuseMedicare beneficiariesInfarctionPatientsElderly adultsAlcohol dependenceQuality care
2005
The practice of office-based buprenorphine treatment of opioid dependence: is it associated with new patients entering into treatment?
Sullivan LE, Chawarski M, O’Connor P, Schottenfeld RS, Fiellin DA. The practice of office-based buprenorphine treatment of opioid dependence: is it associated with new patients entering into treatment? Drug And Alcohol Dependence 2005, 79: 113-116. PMID: 15943950, DOI: 10.1016/j.drugalcdep.2004.12.008.Peer-Reviewed Original ResearchConceptsPrimary care clinicsInjection drug useOpioid treatment programsMethadone treatmentOpioid dependenceClinical trialsTreatment outcomesHistory of IDUOffice-based buprenorphine treatmentOffice-based buprenorphineBuprenorphine/naloxoneOffice-based treatmentLower ratesHepatitis CClinical characteristicsBuprenorphine treatmentCare clinicsMethadone maintenancePCC patientsNew patientsTreatment retentionPatientsDrug useTreatment programBuprenorphinePrimary Intensive Care: Pilot Study of a Primary CareBased Intervention for High-Utilizing Patients
Brown KE, Levine JM, Fiellin DA, O'connor P, Sledge WH. Primary Intensive Care: Pilot Study of a Primary CareBased Intervention for High-Utilizing Patients. Population Health Management 2005, 8: 169-177. PMID: 15966782, DOI: 10.1089/dis.2005.8.169.Peer-Reviewed Original ResearchConceptsPilot studyHospital cost differencesWeekly multidisciplinary clinicHigher healthcare utilizationPrimary care patientsEmergency department usePrimary care centersPresence of psychopathologyManagement patientsCare patientsHealthcare utilizationMultidisciplinary clinicIntensive careDepartment useCare centerInpatient servicesPatientsPsychiatric diagnosisSpecial interventionStaff satisfactionStatistical significanceInterventionClinicCost differencesDiagnosis
2003
Initial and Maintenance Naltrexone Treatment for Alcohol Dependence Using Primary Care vs Specialty Care: A Nested Sequence of 3 Randomized Trials
O'Malley SS, Rounsaville BJ, Farren C, Namkoong K, Wu R, Robinson J, O'Connor PG. Initial and Maintenance Naltrexone Treatment for Alcohol Dependence Using Primary Care vs Specialty Care: A Nested Sequence of 3 Randomized Trials. JAMA Internal Medicine 2003, 163: 1695-1704. PMID: 12885685, DOI: 10.1001/archinte.163.14.1695.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlanine TransaminaseAlcoholismAspartate AminotransferasesCognitive Behavioral TherapyCombined Modality TherapyConnecticutFemaleGamma-GlutamyltransferaseHumansMaleMedicineMiddle AgedNaltrexoneNarcotic AntagonistsPatient CompliancePatient ParticipationPrimary Health CareSpecializationTimeTreatment OutcomeConceptsPrimary care managementCognitive behavior therapyPlacebo-controlled studyAlcohol dependenceNaltrexone treatmentPersistent heavy drinkingPrimary care treatmentWeeks of treatmentMaintenance of responseMaintenance of improvementCBT armCBT patientsPlacebo groupNaltrexone maintenanceRandomized trialsCare treatmentPrimary careSpecialty carePCM patientsDays abstinentNaltrexoneInitial courseCare managementCBT respondersPatientsMeasuring Alcohol Consumption Among Older Adults: A Comparison of Available Methods
Reid MC, Tinetti ME, O'Connor PG, Kosten TR, Concato J. Measuring Alcohol Consumption Among Older Adults: A Comparison of Available Methods. American Journal On Addictions 2003, 12: 211-219. PMID: 12851017, DOI: 10.1111/j.1521-0391.2003.tb00649.x.Peer-Reviewed Original ResearchConceptsAlcohol exposureVA primary care clinicsOlder adultsCommunity-dwelling Medicare beneficiariesQuantity-frequency questionsPrimary care clinicsAlcohol Use Disorders Identification TestPercentage of participantsDisorders Identification TestCare clinicsAlcohol historyCurrent drinkersOlder veteransMedicare beneficiariesAlcohol consumptionElderly adultsOlder personsLevel of agreementAlcohol useIdentification TestKappa valuesAdultsAlcohol measuresConcordanceExposure
2002
The Health-Related Effects of Alcohol Use in Older Persons: A Systematic Review
Reid MC, Boutros NN, O'Connor PG, Cadariu A, Concato J. The Health-Related Effects of Alcohol Use in Older Persons: A Systematic Review. Substance Abuse 2002, 23: 149-164. DOI: 10.1023/a:1019896822588.Peer-Reviewed Original ResearchConceptsCause mortalityCognitive impairmentExposure statusFunctional disabilityAlcohol useOlder adultsFunctional impairmentMiddle-aged adult populationParticipants 60 yearsYears of ageEnglish-language studiesExposure-outcome associationsImportant confounding factorsHealth-related effectsEffects of alcoholMagnitude of riskCohort studySubstantial morbidityPercentage of studiesFormer drinkersProspective studyMean ageAlcohol exposureMethodologic qualityOutcome measuresThe Health–Related Effects of Alcohol Use in Older Persons: A Systematic Review
Reid M, Boutros N, O'Connor P, Cadariu A, Concato J. The Health–Related Effects of Alcohol Use in Older Persons: A Systematic Review. Substance Abuse 2002, 23: 149-164. PMID: 12444348, DOI: 10.1080/08897070209511485.Peer-Reviewed Original ResearchConceptsCause mortalityCognitive impairmentExposure statusFunctional disabilityAlcohol useOlder adultsFunctional impairmentMiddle-aged adult populationParticipants 60 yearsYears of ageEnglish-language studiesExposure-outcome associationsImportant confounding factorsHealth-related effectsEffects of alcoholMagnitude of riskCohort studySubstantial morbidityPercentage of studiesFormer drinkersProspective studyMean ageAlcohol exposureMethodologic qualityOutcome measuresRisk for Delirium Tremens in Patients with Alcohol Withdrawal Syndrome1
Fiellin DA, O'Connor PG, Holmboe ES, Horwitz RI. Risk for Delirium Tremens in Patients with Alcohol Withdrawal Syndrome1. Substance Abuse 2002, 23: 83-94. PMID: 12444353, DOI: 10.1080/08897070209511478.Peer-Reviewed Original ResearchConceptsAdverse clinical featuresDelirium tremensComplicated withdrawalBlood pressureAlcohol withdrawalClinical featuresComplicated alcohol withdrawalElevated blood pressureSystolic blood pressureCase-control studyDSM-IV criteriaComorbidity scoreMedical comorbiditiesDetoxification unitEligibility criteriaTremensWithdrawalRiskComorbiditiesPatientsAdmissionHospitalCasesControlUse of Opioid Medications for Chronic Noncancer Pain Syndromes in Primary Care
Reid MC, Engles‐Horton L, Weber MB, Kerns RD, Rogers EL, O'Connor PG. Use of Opioid Medications for Chronic Noncancer Pain Syndromes in Primary Care. Journal Of General Internal Medicine 2002, 17: 173-179. PMID: 11929502, PMCID: PMC1495018, DOI: 10.1046/j.1525-1497.2002.10435.x.Peer-Reviewed Original ResearchConceptsChronic noncancer painChronic pain disordersPrimary care centersPrimary care settingNoncancer painOpioid medicationsAbuse/dependenceSubstance use disordersPain disordersPsychiatric comorbidityPCC patientsPrimary careCare settingsUse disordersLifetime historyVA primary care clinicsAlcohol abuse/dependenceRetrospective cohort studyProportion of patientsMedical record reviewPrimary care clinicsChronic pain diagnosesAbuse behaviorsDegenerative joint diseaseLifetime prevalence rates
2000
Screening for Alcohol Problems in Primary Care: A Systematic Review
Fiellin DA, Reid MC, O'Connor PG. Screening for Alcohol Problems in Primary Care: A Systematic Review. JAMA Internal Medicine 2000, 160: 1977-1989. PMID: 10888972, DOI: 10.1001/archinte.160.13.1977.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestPrimary careAlcohol problemsFormal screening instrumentsAlcohol abuseHarmful drinkingScreening instrumentQuantity-frequency questionsPrimary care physiciansSearch of MEDLINEDisorders Identification TestCAGE questionsCare physiciansClinical subgroupsClinical measuresCriterion standardDiagnostic test researchSystematic reviewPatient spectrumDiagnostic testsMethodological standardsCareIdentification TestWorkup biasMethodological limitationsNaltrexone-Induced Nausea in Patients Treated for Alcohol Dependence: Clinical Predictors and Evidence for Opioid-Mediated Effects
O'Malley S, Krishnan-Sarin S, Farren C, O'Connor P. Naltrexone-Induced Nausea in Patients Treated for Alcohol Dependence: Clinical Predictors and Evidence for Opioid-Mediated Effects. Journal Of Clinical Psychopharmacology 2000, 20: 69-76. PMID: 10653211, DOI: 10.1097/00004714-200002000-00012.Peer-Reviewed Original ResearchConceptsRisk of nauseaEndogenous opioid systemIntensity of drinkingSevere nauseaOpioid systemAlcohol useLight drinkersMost alcoholic patientsWeeks of naltrexoneOpen-label trialLong-term alcohol usePoor medication compliancePretreatment patient characteristicsLogistic regression analysisAlcohol-dependent subjectsDays of abstinenceDuration of abstinenceSignificant nauseaPatient characteristicsClinical predictorsEndogenous opioidsMedication complianceAlcoholic patientsNaltrexone doseRisk factors
1998
Alcohol abusers in primary care: readiness to change behavior
Samet J, O’Connor P. Alcohol abusers in primary care: readiness to change behavior. The American Journal Of Medicine 1998, 105: 302-306. PMID: 9809691, DOI: 10.1016/s0002-9343(98)00258-7.Peer-Reviewed Original ResearchConceptsCAGE questionnaireAlcohol abusePrimary careMean ageUrban primary care clinicAlcohol usePercent of patientsMinority of patientsPrimary care clinicsPrimary care settingSubjects' mean ageContemplation stagePositive responseSubstance abuse treatmentStage of readinessAssessment of stagesMost patientsCare clinicsCare settingsAlcohol abusersLong-term recoveryPatientsRelapse preventionAbuse treatmentFurther evaluation