2019
Integrated stepped alcohol treatment for patients with HIV and alcohol use disorder: a randomised controlled trial
Edelman EJ, Maisto SA, Hansen NB, Cutter CJ, Dziura J, Deng Y, Fiellin LE, O'Connor PG, Bedimo R, Gibert CL, Marconi VC, Rimland D, Rodriguez-Barradas MC, Simberkoff MS, Tate JP, Justice AC, Bryant KJ, Fiellin DA. Integrated stepped alcohol treatment for patients with HIV and alcohol use disorder: a randomised controlled trial. The Lancet HIV 2019, 6: e509-e517. PMID: 31109915, PMCID: PMC7161741, DOI: 10.1016/s2352-3018(19)30076-1.Peer-Reviewed Original ResearchConceptsAlcohol use disorderWeek 24Use disordersAlcohol treatmentAdverse eventsNumber of drinksTreatment medicationsPhysician managementAlcohol abuseMental Disorders-IV criteriaAlcohol-related careFormal alcohol treatmentKey exclusion criteriaTimeline followback methodMotivational enhancement therapyTreat populationHIV clinicHIV outcomesPrimary outcomeSpecialty referralsMean ageUS National InstitutesWeek 4Medical conditionsExclusion criteria
2012
Brief versus extended counseling along with buprenorphine/naloxone for HIV-infected opioid dependent patients
Tetrault JM, Moore BA, Barry DT, O'Connor PG, Schottenfeld R, Fiellin DA, Fiellin LE. Brief versus extended counseling along with buprenorphine/naloxone for HIV-infected opioid dependent patients. Journal Of Substance Use And Addiction Treatment 2012, 43: 433-439. PMID: 22938914, DOI: 10.1016/j.jsat.2012.07.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultBuprenorphineBuprenorphine, Naloxone Drug CombinationCounselingDelivery of Health Care, IntegratedFeasibility StudiesFemaleFollow-Up StudiesHIV InfectionsHumansMaleMiddle AgedNaloxoneNarcotic AntagonistsOpioid-Related DisordersPsychotherapy, BriefSubstance Abuse DetectionTime FactorsTreatment OutcomeViral LoadConceptsEnhanced medical managementPhysician managementDetectable HIV viral loadHIV treatment settingsOpioid-negative urinesBuprenorphine/naloxoneHIV viral loadOpioid-dependent patientsPercentage of subjectsUntreated opioid dependenceExtended counselingHIV clinicHIV outcomesBuprenorphine/Medical managementOpioid dependenceViral loadDependent patientsExtensive counselingClinical trialsContinuous abstinenceNegative urineTreatment settingsGroup differencesCounseling
2008
Long‐Term Treatment with Buprenorphine/Naloxone in Primary Care: Results at 2–5 Years
Fiellin DA, Moore BA, Sullivan LE, Becker WC, Pantalon MV, Chawarski MC, Barry DT, O'Connor PG, Schottenfeld RS. Long‐Term Treatment with Buprenorphine/Naloxone in Primary Care: Results at 2–5 Years. American Journal On Addictions 2008, 17: 116-120. PMID: 18393054, DOI: 10.1080/10550490701860971.Peer-Reviewed Original ResearchMeSH KeywordsAdultBuprenorphineCombined Modality TherapyCounselingCross-Sectional StudiesDose-Response Relationship, DrugDrug Administration ScheduleDrug Therapy, CombinationFemaleFollow-Up StudiesHeroin DependenceHumansLong-Term CareMaleMiddle AgedNaloxoneNarcotic AntagonistsOpioid-Related DisordersPatient DropoutsPrimary Health CareSubstance Abuse DetectionTreatment OutcomeConceptsOpioid-dependent patientsAdverse eventsSerum transaminasesBuprenorphine/naloxone treatmentSerious adverse eventsBuprenorphine/naloxoneLong-term outcomesOffice-based treatmentIllicit drug useOpioid useClinical stabilityNaloxone treatmentPrimary outcomePatient satisfactionPrimary careTerm treatmentDrug useUrine samplesPatientsTreatmentTransaminaseOutcomesYearsModerate levelsPercent
2007
Brief interventions for problem drinking: another piece of the puzzle.
O'Connor PG. Brief interventions for problem drinking: another piece of the puzzle. Annals Of Internal Medicine 2007, 146: 223-5. PMID: 17283352, DOI: 10.7326/0003-4819-146-3-200702060-00012.Peer-Reviewed Original Research
2006
Counseling plus Buprenorphine–Naloxone Maintenance Therapy for Opioid Dependence
Fiellin DA, Pantalon MV, Chawarski MC, Moore BA, Sullivan LE, O'Connor PG, Schottenfeld RS. Counseling plus Buprenorphine–Naloxone Maintenance Therapy for Opioid Dependence. New England Journal Of Medicine 2006, 355: 365-374. PMID: 16870915, DOI: 10.1056/nejmoa055255.Peer-Reviewed Original ResearchConceptsStandard medical managementBuprenorphine-naloxone treatmentIllicit opioid useMedical managementOpioid dependenceWeekly medicationOpioid useIllicit opioidsWeekly counselingPrimary careUrine specimensConsecutive weeksProportion of patientsImproved treatment outcomesMaintenance therapyPrimary outcomeClinical trialsMedication distributionSimilar efficacyTreatment outcomesMedicationsSelf-reported frequencyPatientsFrequency of attendanceMean percentage
2005
Development and Implementation of an Emergency Practitioner–Performed Brief Intervention for Hazardous and Harmful Drinkers in the Emergency Department
D'Onofrio G, Pantalon MV, Degutis LC, Fiellin DA, O'Connor PG. Development and Implementation of an Emergency Practitioner–Performed Brief Intervention for Hazardous and Harmful Drinkers in the Emergency Department. Academic Emergency Medicine 2005, 12: 249-256. PMID: 15741590, PMCID: PMC1414059, DOI: 10.1197/j.aem.2004.10.021.Peer-Reviewed Original ResearchConceptsBrief Negotiation InterviewEmergency practitionersEmergency departmentBrief interventionClinical careEfficacy of BIRoutine clinical careMean durationPatient outcomesHarmful drinkersStandardized patient scenariosClinical practicePatient scenariosDrinkersMean numberInterventionTraining sessionsCarePilot testingDepartmentSessionsHospitalTrialsProblem Drinkers: Find Them, Keep Them, Don't Lose Them—Treat Them
O'Connor PG. Problem Drinkers: Find Them, Keep Them, Don't Lose Them—Treat Them. Journal Of General Internal Medicine 2005, 20: 96-97. PMID: 15693936, PMCID: PMC1490046, DOI: 10.1111/j.1525-1497.2005.04005.x.Peer-Reviewed Original Research
2002
Treatment of heroin dependence with buprenorphine in primary care
Fiellin DA, Pantalon MV, Pakes JP, O'Connor PG, Chawarski M, Schottenfeld RS. Treatment of heroin dependence with buprenorphine in primary care. The American Journal Of Drug And Alcohol Abuse 2002, 28: 231-241. PMID: 12014814, DOI: 10.1081/ada-120002972.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, SublingualAdultAmbulatory CareBuprenorphineCombined Modality TherapyConnecticutCounselingDose-Response Relationship, DrugDrug Administration ScheduleFeasibility StudiesFemaleHeroin DependenceHumansMaleMiddle AgedPrimary Health CareSocial SupportTreatment OutcomeUrban PopulationConceptsUrine toxicologyHeroin dependencePrimary careBrief counselingUrine toxicology testsHeroin-dependent patientsPrimary care settingPrimary care centersUrban medical centerBuprenorphine maintenancePrimary outcomeDependent patientsCare centerClinical trialsCare settingsMedical CenterEffective treatmentTreatment retentionBuprenorphinePatientsPotential efficacyToxicology testsMaintenance phaseWeeksCare
2000
Outpatient management of patients with alcohol problems.
Fiellin DA, Reid MC, O'Connor PG. Outpatient management of patients with alcohol problems. Annals Of Internal Medicine 2000, 133: 815-27. PMID: 11085845, DOI: 10.7326/0003-4819-133-10-200011210-00015.Peer-Reviewed Original ResearchPharmacologic treatment of heroin-dependent patients.
O'Connor P, Fiellin D. Pharmacologic treatment of heroin-dependent patients. Annals Of Internal Medicine 2000, 133: 40-54. PMID: 10877739, DOI: 10.7326/0003-4819-133-1-200007040-00008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHeroin dependenceHeroin-dependent patientsDrug treatment settingsBehavioral health problemsOpioid withdrawalPharmacologic treatmentMethadone maintenanceHeroin usePhysician's officeTreatment approachesTreatment settingsHealth problemsPatientsRelapse preventionTreatmentPhysiciansAcetylmethadolBuprenorphineInternistsReferralDiagnosisAlternative sitesPrevention
1997
A Preliminary Investigation of the Management of Alcohol Dependence With Naltrexone by Primary Care Providers
O’Connor P, Farren C, Rounsaville B, O’Malley S. A Preliminary Investigation of the Management of Alcohol Dependence With Naltrexone by Primary Care Providers. The American Journal Of Medicine 1997, 103: 477-482. PMID: 9428830, DOI: 10.1016/s0002-9343(97)00271-4.Peer-Reviewed Original ResearchConceptsPrimary care providersCare providersGamma-glutamyl transferaseAlcohol dependenceDays abstinentHeavy drinkingSerum gamma-glutamyl transferaseCare treatment modelCompletion of treatmentPercent days abstinentAlcohol-dependent subjectsAlcohol-dependent individualsNaltrexone therapyNumber of drinksPrimary outcomeLiver enzymesPatient ratingsNew patientsGlutamyl transferaseNaltrexoneProvider ratingsBaselineTreatment modelTreatmentDrinking behavior