2020
Redefining the Role of Surgical Management of Metastatic Renal Cell Carcinoma
Hsiang WR, Kenney PA, Leapman MS. Redefining the Role of Surgical Management of Metastatic Renal Cell Carcinoma. Current Oncology Reports 2020, 22: 35. PMID: 32170461, DOI: 10.1007/s11912-020-0895-y.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaSystemic therapyRenal cell carcinomaCytoreductive nephrectomySurgical therapyCell carcinomaManagement of mRCCPoor-risk metastatic renal cell carcinomaInitial systemic therapyReviewThe treatment landscapeTargeted therapy eraUpfront cytoreductive nephrectomyViable treatment approachSequence of surgeryTherapy eraTreatment landscapeUnselected patientsSurgical managementSummaryRecent evidenceRecent FindingsOneTreatment approachesNephrectomyTherapyOptimal rolePatients
2019
Outcomes for urologic oncology procedures: are there differences between academic and community hospitals?
Syed JS, Abello A, Nguyen J, Lee AJH, Desloges JJ, Leapman MS, Kenney PA. Outcomes for urologic oncology procedures: are there differences between academic and community hospitals? World Journal Of Urology 2019, 38: 1187-1193. PMID: 31420696, DOI: 10.1007/s00345-019-02902-8.Peer-Reviewed Original ResearchConceptsLength of stayCommunity hospitalAcademic hospitalReadmission ratesRadical cystectomyHospital-based outcomesDirect costsMean direct costUrologic oncology proceduresStudent's t-testCase mix indexIndex admissionVizient databaseRadical nephroureterectomyPartial cystectomySurgical treatmentUrologic malignanciesOncologic proceduresPartial nephrectomyCystectomyOncology proceduresAcademic centersHospitalProstatectomyStay
2016
Robotic-assisted laparoscopic versus open salvage radical prostatectomy following radiotherapy.
Kenney PA, Nawaf CB, Mustafa M, Wen S, Wszolek MF, Pettaway CA, Ward JF, Davis JW, Pisters LL. Robotic-assisted laparoscopic versus open salvage radical prostatectomy following radiotherapy. Canadian Journal Of Urology 2016, 23: 8271-7. PMID: 27347619, PMCID: PMC5512888.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnastomotic LeakBlood Loss, SurgicalHumansIntraoperative ComplicationsLaparoscopyLymph Node ExcisionLymphatic MetastasisMaleMargins of ExcisionMiddle AgedNeoplasm Recurrence, LocalPelvisProstatectomyProstate-Specific AntigenProstatic NeoplasmsRobotic Surgical ProceduresSalvage TherapySurgical Wound InfectionTreatment OutcomeConceptsSalvage radical prostatectomyOpen groupRadical prostatectomySurgical marginsNode yieldRadiation therapyExact testOpen salvage radical prostatectomyProstate-specific antigen rateRetrospective single-institution seriesPositive surgical marginsSingle-institution seriesRobotic-assisted laparoscopic
2015
Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney: a detailed study of radiological, pathological and clinical outcomes
Kenney PA, Vikram R, Prasad SR, Tamboli P, Matin SF, Wood CG, Karam JA. Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney: a detailed study of radiological, pathological and clinical outcomes. BJU International 2015, 116: 85-92. PMID: 25395040, DOI: 10.1111/bju.12992.Peer-Reviewed Original ResearchConceptsSpindle cell carcinomaCell carcinomaSingle-institution retrospective analysisContrast-enhanced computed tomographyRenal cell carcinoma variantsPT3a diseaseOncological outcomesSalvage surgeryClinical characteristicsMetastatic diseaseFemale predominanceMedian ageClinical outcomesRadical nephrectomyFemale predilectionExcellent outcomesPathological featuresCarcinoma variantsSarcomatoid dedifferentiationActive surveillanceHistological featuresRetrospective analysisEnergy ablationComputed tomographyPapillary RCC
2013
Preoperative Pulmonary Embolism Does Not Predict Poor Postoperative Outcomes in Patients with Renal Cell Carcinoma and Venous Thrombus
Abel EJ, Wood CG, Eickstaedt N, Fang JE, Kenney P, Bagrodia A, Youssef RF, Sagalowsky AI, Margulis V. Preoperative Pulmonary Embolism Does Not Predict Poor Postoperative Outcomes in Patients with Renal Cell Carcinoma and Venous Thrombus. Journal Of Urology 2013, 190: 452-457. PMID: 23434945, DOI: 10.1016/j.juro.2013.02.033.Peer-Reviewed Original ResearchConceptsPreoperative pulmonary embolismCancer-specific survivalRenal cell carcinomaPulmonary embolismPoor postoperative outcomesCell carcinomaSpecific survivalVenous thrombiPostoperative outcomesMetastatic renal cell carcinomaCox proportional hazards analysisWorse cancer-specific survivalConsecutive patient recordsHigh-level thrombusProportional hazards analysisHigher T stagePostoperative disease recurrencePerioperative mortalityMedian followupDisease recurrenceTumor thrombusT stageTertiary hospitalEarly mortalityMulticenter study
2012
Integration of Surgery and Systemic Therapy for Renal Cell Carcinoma
Kenney PA, Wood CG. Integration of Surgery and Systemic Therapy for Renal Cell Carcinoma. Urologic Clinics Of North America 2012, 39: 211-231. PMID: 22487764, DOI: 10.1016/j.ucl.2012.01.005.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic Agents, HormonalCarcinoma, Renal CellChemotherapy, AdjuvantCombined Modality TherapyFemaleHumansImmunotherapyKidney NeoplasmsMaleNeoadjuvant TherapyNeoplasm InvasivenessNeoplasm StagingNephrectomyPrognosisRadiotherapy, AdjuvantRisk AssessmentSurvival AnalysisTreatment OutcomeConceptsRenal cell carcinomaSystemic therapyCell carcinomaMetastatic renal cell carcinomaAdvanced nonmetastatic diseaseUpfront cytoreductive nephrectomyIntegration of surgeryCytoreductive nephrectomyCytoreductive surgeryNeoadjuvant therapyNonmetastatic diseaseAdjuvant therapyMetastatic diseaseAppropriate patientsTherapySurgeryDiseaseCurrent roleNephrectomyFurther studiesCarcinomaPotential benefitsPatientsTrialsUnidirectional barbed suture versus standard monofilament for urethrovesical anastomosis during robotic assisted laparoscopic radical prostatectomy
Manganiello M, Kenney P, Canes D, Sorcini A, Moinzadeh A. Unidirectional barbed suture versus standard monofilament for urethrovesical anastomosis during robotic assisted laparoscopic radical prostatectomy. International Braz J Urol 2012, 38: 89-96. PMID: 22397770, DOI: 10.1590/s1677-55382012000100013.Peer-Reviewed Original ResearchConceptsUnidirectional barbed sutureBladder neck contractureUrethrovesical anastomosisBarbed sutureV-LocUrinary incontinenceNeck contractureDaily pad usageAnastomotic leak ratePercentage of patientsBody mass indexLaparoscopic radical prostatectomyUrine leakBlood lossConsecutive patientsUrinary extravasationMass indexClinical symptomsEarly continencePathologic stageProstate sizeGleason scorePad usageRadical prostatectomyLaparoscopic prostatectomy
2010
Comparison of hilar clamping and non‐hilar clamping partial nephrectomy for tumours involving a solitary kidney
Wszolek MF, Kenney PA, Lee Y, Libertino JA. Comparison of hilar clamping and non‐hilar clamping partial nephrectomy for tumours involving a solitary kidney. BJU International 2010, 107: 1886-1892. PMID: 21070570, DOI: 10.1111/j.1464-410x.2010.09713.x.Peer-Reviewed Original ResearchConceptsLatest glomerular filtration ratesGlomerular filtration rateNon-clamping groupEarly glomerular filtration ratePreoperative glomerular filtration rateSolitary functional kidneyHilar clampingPartial nephrectomyClamping groupSolitary kidneySpecific survivalRenal cell carcinoma-specific survivalInstitutional review board-approved retrospective reviewSurgical margin positivity ratesFunctional kidneyMean ischaemia timeSimilar cancer controlRenal Disease equationLocal recurrence rateMargin positivity ratesModification of DietCarcinoma-specific survivalSpectrum of complicationsNumber of tumorsAutotransplant proceduresNon‐clamped partial nephrectomy: techniques and surgical outcomes
Smith GL, Kenney PA, Lee Y, Libertino JA. Non‐clamped partial nephrectomy: techniques and surgical outcomes. BJU International 2010, 107: 1054-1058. PMID: 21040369, DOI: 10.1111/j.1464-410x.2010.09798.x.Peer-Reviewed Original ResearchConceptsPartial nephrectomyVascular clampingGroup AGroup BSolitary kidneyRenal functionBlood lossOncological efficacyPercentage changeVon Hippel-Lindau diseaseFour-variable ModificationRenal vascular clampingMedian tumor sizeRate of complicationsRenal Disease equationGlomerular filtration rateSubset of patientsMedian percentage changeRate of recurrencePositive margin rateHippel-Lindau diseaseUnclamped groupPerioperative deathsPreoperative eGFRRetrospective review