Novel ZEB1 expression in bladder tumorigenesis
Kenney PA, Wszolek MF, Rieger‐Christ K, Neto BS, Gould JJ, Harty NJ, Mosquera JM, Zeheb R, Loda M, Darling DS, Libertino JA, Summerhayes IC. Novel ZEB1 expression in bladder tumorigenesis. BJU International 2010, 107: 656-663. PMID: 20735391, DOI: 10.1111/j.1464-410x.2010.09489.x.Peer-Reviewed Original ResearchConceptsEpithelial-mesenchymal transitionTransitional cell carcinomaZEB1 expressionNuclear ZEB1 expressionTissue microarrayBladder tumorsTumor progressionGrade I/IIBladder tumorigenesisMuscle-invasive UCBCancer-specific survivalGrade III tumorsNormal bladder mucosaExpression levelsExpression of ZEB1Underlying cellular changesCell linesBladder cell linesUM-UC-3Bladder tumor progressionProtein expression levelsBladder carcinoma cell lineInvasive UCBWestern blot analysisNodal involvementIdentification of Tumor and Invasion Suppressor Gene Modulators in Bladder Cancer by Different Classes of Histone Deacetylase Inhibitors Using Reverse Phase Protein Arrays
Gould JJ, Kenney PA, Rieger-Christ KM, Neto B, Wszolek MF, LaVoie A, Holway AH, Spurrier B, Austin J, Cammarata BK, Canes D, Libertino JA, Summerhayes IC. Identification of Tumor and Invasion Suppressor Gene Modulators in Bladder Cancer by Different Classes of Histone Deacetylase Inhibitors Using Reverse Phase Protein Arrays. Journal Of Urology 2010, 183: 2395-2402. PMID: 20403623, DOI: 10.1016/j.juro.2010.02.004.Peer-Reviewed Original ResearchConceptsReverse phase protein arrayPhase protein arrayHistone deacetylase inhibitorsInvasive cell linesDeacetylase inhibitorsProtein arraysExpression profilesCell linesProtein expression profilesMS-275Specific protein groupsSuppressor gene expressionHigh-throughput screeningGene expressionGene modulatorsTrichostatin AInvasive linesSuppressor geneBladder carcinoma cell lineProtein groupsFAK expressionCarcinoma cell linesBladder cancerValproic acidThroughput screening