2017
Molecular basis of tactile specialization in the duck bill
Schneider ER, Anderson EO, Mastrotto M, Matson JD, Schulz VP, Gallagher PG, LaMotte RH, Gracheva EO, Bagriantsev SN. Molecular basis of tactile specialization in the duck bill. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 13036-13041. PMID: 29109250, PMCID: PMC5724259, DOI: 10.1073/pnas.1708793114.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAvian ProteinsBeakChickensCloning, MolecularDucksEmbryo, NonmammalianGene ExpressionGenetic VectorsHEK293 CellsHumansIon ChannelsKineticsMechanoreceptorsMechanotransduction, CellularMicePatch-Clamp TechniquesRecombinant ProteinsRNA, Small InterferingSequence Homology, Amino AcidSpecies SpecificityTouchTouch PerceptionTrigeminal GanglionConceptsMolecular basisHeterologous expression systemSpecialist birdsMouse orthologPiezo2 ion channelsTactile specializationExpression systemDuck billMolecular characterizationIon channelsFeeding behaviorEdible matterPiezo2BirdsElectrophysiological characterizationSlow inactivation kineticsOrthologsVertebratesMechanoMechanotransductionKnockdownInactivation kineticsMurky watersHigh densityNeurons
2014
Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl
Schneider ER, Mastrotto M, Laursen WJ, Schulz VP, Goodman JB, Funk OH, Gallagher PG, Gracheva EO, Bagriantsev SN. Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 14941-14946. PMID: 25246547, PMCID: PMC4205607, DOI: 10.1073/pnas.1413656111.Peer-Reviewed Original ResearchConceptsTrigeminal ganglionIon channel Piezo2Light mechanical stimuliMechanoreceptive neuronsTG neuronsPrimary afferentsMechanical stimuliTrigeminal afferentsNeuronal excitationEnd organsNeuronal mechanismsDirect mechanical stimulationCellular mechanismsMechanical stimulationAfferentsNeuronsLow thresholdNumerical expansionGangliaStimuli