Hematologic disorders and nonimmune hydrops fetalis
Arcasoy M, Gallagher P. Hematologic disorders and nonimmune hydrops fetalis. Seminars In Perinatology 1995, 19: 502-515. PMID: 8822334, DOI: 10.1016/s0146-0005(05)80057-6.Peer-Reviewed Original ResearchConceptsNonimmune hydrops fetalisHematologic disordersHydrops fetalisTwin-twin transfusionFetal blood lossGlucose-6-phosphate dehydrogenase deficiencyFinal common denominatorBlood lossHeart failureFetomaternal hemorrhageNonimmune hydropsErythrocyte lossDehydrogenase deficiencyErythrocyte abnormalitiesErythrocyte productionDisordersHemorrhageAnemiaFetalisAnasarcaTransfusionAscitesEdemaHydropsFailureRecurrent fatal hydrops fetalis associated with a nucleotide substitution in the erythrocyte beta-spectrin gene.
Gallagher PG, Weed SA, Tse WT, Benoit L, Morrow JS, Marchesi SL, Mohandas N, Forget BG. Recurrent fatal hydrops fetalis associated with a nucleotide substitution in the erythrocyte beta-spectrin gene. Journal Of Clinical Investigation 1995, 95: 1174-1182. PMID: 7883966, PMCID: PMC441455, DOI: 10.1172/jci117766.Peer-Reviewed Original ResearchConceptsBeta-spectrin geneErythrocyte membrane mechanical stabilityPrincipal structural proteinMembrane mechanical stabilitySpectrin functionBeta spectrinErythrocyte membranesNucleotide substitutionsStudy of erythrocytesStructural proteinsAlpha-spectrinGenetic studiesMolecular defectsPoint mutationsSpectrinHydrops fetalisRecombinant peptideMutationsGenesSevere Coomb's negative hemolytic anemiaThird-trimester fetal loss