2009
Exocyst is involved in polarized cell migration and cerebral cortical development
Letinic K, Sebastian R, Toomre D, Rakic P. Exocyst is involved in polarized cell migration and cerebral cortical development. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 11342-11347. PMID: 19549839, PMCID: PMC2708724, DOI: 10.1073/pnas.0904244106.Peer-Reviewed Original ResearchConceptsCell migrationDelivery of vesiclesNeuronal migrationVesicle tetheringExocyst complexMembrane trafficExocytic pathwayProtein complexesExocytic processExocystSpatial regulationEmbryonic developmentVesicle exocytosisSecretory vesiclesPlasma membraneTIRF microscopyPostmitotic cellsCortical neuronal migrationProper developmentCerebral cortical developmentWound assaysExocytosisVesiclesMembraneCells
1999
Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex1Published on the World Wide Web on 8 July 1999.1
Haydar T, Bambrick L, Krueger B, Rakic P. Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex1Published on the World Wide Web on 8 July 1999.1. Brain Research 1999, 4: 425-437. PMID: 10592354, DOI: 10.1016/s1385-299x(99)00033-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBromodeoxyuridineCell DivisionCell MovementCell SurvivalFemaleFetusFluorescent Antibody TechniqueGlial Fibrillary Acidic ProteinIn Situ Nick-End LabelingMiceMice, Inbred ICRMicroscopy, ConfocalMicrotubule-Associated ProteinsNeocortexNeurogliaNeuronsOrgan Culture TechniquesPregnancyConceptsCell deathProper cortical developmentCell-cell interactionsDynamic cellular interactionsQuantitative confocal microscopyDiffusible regulatorsPrimary cell culturesAnalysis of proliferationCellular interactionsCellular mechanismsCortical neurogenesisNeuronal migrationConfocal microscopyCell proliferationNeocortical neurogenesisExperimental manipulationThree-dimensional environmentVivo processesCell culturesNeurogenesisPhysiological methodsTropic supportOrganotypic slice culturesProliferationCortical developmentDistinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex
Anton E, Kreidberg J, Rakic P. Distinct Functions of α3 and αV Integrin Receptors in Neuronal Migration and Laminar Organization of the Cerebral Cortex. Neuron 1999, 22: 277-289. PMID: 10069334, DOI: 10.1016/s0896-6273(00)81089-2.Peer-Reviewed Original ResearchConceptsCerebral cortexNeuronal migrationNeuron-glial interactionsΑv integrin receptorsRadial glial cellsRadial glial fibersCortical neuronsGlial cellsAbnormal layeringLaminar organizationGlial fibersCortexNeuronsSpecific cell-cell recognitionAlpha3beta1 integrinIntegrin receptorsIntegrin geneIntegrinsTargeted mutationsIntegrin functionCorticogenesisReceptors
1998
Orchestration of neuronal migration by activity of ion channels, neurotransmitter receptors, and intracellular Ca2+ fluctuations
Komuro H, Rakic P. Orchestration of neuronal migration by activity of ion channels, neurotransmitter receptors, and intracellular Ca2+ fluctuations. Developmental Neurobiology 1998, 37: 110-130. PMID: 9777736, DOI: 10.1002/(sici)1097-4695(199810)37:1<110::aid-neu9>3.0.co;2-c.Peer-Reviewed Original ResearchConceptsGranule cellsNeurotransmitter receptorsGranule cell movementN-methyl-D-aspartate (NMDA) subtypeN-type Ca2Different cortical layersIon channelsAcute cerebellar slicesFrequency of Ca2Local cellular milieuPhase of Ca2Position-specific changesVoltage-gated ion channelsGlutamate receptorsSpecific ion channelsCerebellar slicesIntracellular Ca2Transient Ca2Cortical layersReceptor activityNeuronal migrationReceptorsPlasmalemmal surfaceLocal environmental cuesCell migrationDistinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex
Komuro H, Rakic P. Distinct Modes of Neuronal Migration in Different Domains of Developing Cerebellar Cortex. Journal Of Neuroscience 1998, 18: 1478-1490. PMID: 9454856, PMCID: PMC6792738, DOI: 10.1523/jneurosci.18-04-01478.1998.Peer-Reviewed Original ResearchConceptsGranule cellsInternal granular layerBergmann glial fibersGlial fibersMost granule cellsMossy fiber terminalsLocal environmental cuesPurkinje cell layerGranular layerAcute cerebellar slice preparationCerebellar slice preparationSynaptic contactsGranule cell movementSlice preparationFiber terminalsBergmann gliaCerebellar cortexPostmitotic neuronsNeuronal migrationNeuronsSomaCell layerCerebellar neurogenesisPresent studyDifferent cellular microenvironments
1997
Developmental expression, pattern of distribution, and effect on cell aggregation implicate a neuron‐glial junctional domain protein in neuronal migration
Cameron R, Ruffin J, Cho N, Cameron P, Rakic P. Developmental expression, pattern of distribution, and effect on cell aggregation implicate a neuron‐glial junctional domain protein in neuronal migration. The Journal Of Comparative Neurology 1997, 387: 467-488. PMID: 9373008, DOI: 10.1002/(sici)1096-9861(19971103)387:4<467::aid-cne1>3.0.co;2-0.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsRadial glial cell processesGlial cell processesMultiple brain regionsNeuronal cell migrationAstrocyte-astrocyteSubventricular zoneImmunofluorescent localization studiesAstroglial cellsNeuron-neuronCerebellar astrocytesBrain regionsMorphologic featuresNeuronal migrationMonoclonal antibodiesImmunoreactivityAntibodiesNeuronsAstrocytesCell migrationPresent studyDevelopmental expressionPattern of distributionCell migration processesRole of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex.
Anton E, Marchionni M, Lee K, Rakic P. Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex. Development 1997, 124: 3501-10. PMID: 9342043, DOI: 10.1242/dev.124.18.3501.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCell CommunicationCell MovementCerebral CortexCulture TechniquesFatty Acid-Binding Protein 7Fatty Acid-Binding ProteinsGlycoproteinsNerve Growth FactorsNerve Tissue ProteinsNeuregulinsNeurogliaNeuronsRatsRats, Sprague-DawleyReceptor, ErbB-2Receptors, Nerve Growth FactorSignal TransductionConceptsRadial glial developmentRadial glial cellsBrain lipid-binding proteinCerebral cortexGlial cellsNeuronal migrationGlial developmentRadial glial cell functionGlial growth factorGlial cell functionRadial glial fibersRadial glial fiber systemNeuronal cell migrationCortical neuronsGlial interactionsRadial gliaGlial fibersGlial moleculesCortexNeuronsGrowth factorErbB2 receptorCell functionDependent mannerCell migration
1996
Role of neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall
Anton E, Cameron R, Rakic P. Role of neuron-glial junctional domain proteins in the maintenance and termination of neuronal migration across the embryonic cerebral wall. Journal Of Neuroscience 1996, 16: 2283-2293. PMID: 8601808, PMCID: PMC6578523, DOI: 10.1523/jneurosci.16-07-02283.1996.Peer-Reviewed Original ResearchConceptsEmbryonic cerebral wallCerebral wallNeuronal migrationCerebral cortexNeuronal migratory pathwayRadial glial cell processesRadial glial fibersGlial cell processesNormal neuronal migrationCortical plateSlice preparationAntibody exposureGlial fibersMarginal zone regionsMonoclonal antibodiesAntibodiesNeuronsCortexCell substratesMarginal zonePolyclonal antiserumMicrotubular organizationCell processesMigratory pathwaysCell detachment
1995
Dynamics of granule cell migration: a confocal microscopic study in acute cerebellar slice preparations
Komuro H, Rakic P. Dynamics of granule cell migration: a confocal microscopic study in acute cerebellar slice preparations. Journal Of Neuroscience 1995, 15: 1110-1120. PMID: 7869087, PMCID: PMC6577849, DOI: 10.1523/jneurosci.15-02-01110.1995.Peer-Reviewed Original ResearchConceptsCell movementCell migrationPlasma membraneShort stationary phaseCerebellar slice preparationGranule cell migrationMolecular mechanismsMembrane flowConfocal microscopic studiesIndividual cellsNeuronal migrationConfocal microscopyCytological aspectsDil crystalsCellsMembraneBergmann glial fibersGranule cellsMigrationMicrons/hrOld micePostnatal lifeConsiderable variationAcute cerebellar slice preparationStationary phase
1994
Recognition, adhesion, transmembrane signaling and cell motility in guided neuronal migration
Rakic P, Cameron R, Komuro H. Recognition, adhesion, transmembrane signaling and cell motility in guided neuronal migration. Current Opinion In Neurobiology 1994, 4: 63-69. PMID: 8173327, DOI: 10.1016/0959-4388(94)90033-7.Peer-Reviewed Original ResearchConceptsCell motilityDiverse cellular mechanismsMultiple molecular eventsSpecific ion channelsTransmembrane signalingExtracellular substratesMigration of neuronsMolecular eventsSecond messengerMolecular componentsIndividual molecular componentsIon channelsCellular mechanismsNeuronal migrationRecognition receptorsAdhesive interactionsAdhesion moleculesMultiple adhesion moleculesFinal destinationRecent studiesMotilityReceptorsSignalingMessengerMigration
1993
Modulation of Neuronal Migration by NMDA Receptors
Komuro H, Rakic P. Modulation of Neuronal Migration by NMDA Receptors. Science 1993, 260: 95-97. PMID: 8096653, DOI: 10.1126/science.8096653.Peer-Reviewed Original ResearchConceptsNMDA receptorsN-methyl-D-aspartate (NMDA) subtypeEndogenous extracellular glutamateCell migrationNMDA receptor activityElimination of synapsesApplication of glycineSynaptic contactsSlice preparationExtracellular glutamateGlutamate receptorsSpecific antagonistGranule cellsReceptor activityNeuronal migrationNeuronal differentiationReceptorsMouse cerebellumEarly roleBlockadeAntagonistCerebellumSubtypesNeuronsBrain
1992
Selective Role of N-Type Calcium Channels in Neuronal Migration
Komuro H, Rakic P. Selective Role of N-Type Calcium Channels in Neuronal Migration. Science 1992, 257: 806-809. PMID: 1323145, DOI: 10.1126/science.1323145.Peer-Reviewed Original ResearchConceptsN-type calcium channelsCalcium channelsNeuronal migrationT-type calcium channelsCerebellar slice preparationGranule cell migrationImmature neuronsSelective blockadeSlice preparationPostmitotic granule cellsAdult brainGranule cellsSynaptic circuitsNeurotransmitter releasePotassium channelsPlasmalemmal surfaceIncubation mediumCell migrationSelective roleLaser scanning confocal microscopeScanning confocal microscopeBlockadeSpecific developmental roleNeuronsBrain
1988
Defects of neuronal migration and the pathogenesis of cortical malformations
Rakic P, Swaab D. Defects of neuronal migration and the pathogenesis of cortical malformations. Progress In Brain Research 1988, 73: 15-37. PMID: 3047794, DOI: 10.1016/s0079-6123(08)60494-x.Peer-Reviewed Original Research
1980
Immunoperoxidase localization of glial fibrillary acidic protein in radial glial cells and astrocytes of the developing rhesus monkey brain
Levitt P, Rakic P. Immunoperoxidase localization of glial fibrillary acidic protein in radial glial cells and astrocytes of the developing rhesus monkey brain. The Journal Of Comparative Neurology 1980, 193: 815-840. PMID: 7002963, DOI: 10.1002/cne.901930316.Peer-Reviewed Original ResearchConceptsGlial fibrillary acidic proteinRadial glial cellsGlial cellsFibrillary acidic proteinBergmann glial cellsGlial fibersNeuronal elementsPial surfacePeroxidase-antiperoxidase immunohistochemical stainingAcidic proteinNeuronal migrationEmbryonic day 38Rhesus monkey brainSecond postnatal monthCentral nervous systemHorseradish peroxidase reaction productRadial fibersSpinal cordPostnatal monthBergmann glial fibersSubventricular zoneImmunohistochemical stainingAstroglial cellsCerebellar cortexImmunohistochemical localization
1979
Arrested proliferation of radial glial cells during midgestation in rhesus monkey
SCHMECHEL D, RAKIC P. Arrested proliferation of radial glial cells during midgestation in rhesus monkey. Nature 1979, 277: 303-305. PMID: 105294, DOI: 10.1038/277303a0.Peer-Reviewed Original ResearchConceptsRadial glial cellsGlial cellsPial surfaceCerebral cortexGlial natureOccipital lobeTelencephalic wallEpendymal cellsGlial fibersRhesus monkeysNeuronal migrationCell classesAutoradiographic analysisVentricular surfaceAstrocytesTwo-thirdsMidgestationPresent studyCellsProliferationGestationPostnatalCerebrumCortexMonths
1973
Neuronal migration, with special reference to developing human brain: a review
Sidman R, Rakic P. Neuronal migration, with special reference to developing human brain: a review. Brain Research 1973, 62: 1-35. PMID: 4203033, DOI: 10.1016/0006-8993(73)90617-3.Peer-Reviewed Original ResearchConceptsCerebellar cortexNervous systemRadial glial guidesGranule cell neuronsCentral nervous systemFetal human brainHuman brainImmunological definitionCerebral cortexCortical plateYoung neuronsAfferent axonsBergmann glial fibersGlial guidesCNS cellsGray nucleiGanglionic eminenceInferior oliveCell neuronsGlial fibersHuman nervous systemMutant miceNeuronal migrationNeuronsCortexWeaver Mutant Mouse Cerebellum: Defective Neuronal Migration Secondary to Abnormality of Bergmann Glia
Rakic P, Sidman R. Weaver Mutant Mouse Cerebellum: Defective Neuronal Migration Secondary to Abnormality of Bergmann Glia. Proceedings Of The National Academy Of Sciences Of The United States Of America 1973, 70: 240-244. PMID: 4509657, PMCID: PMC433223, DOI: 10.1073/pnas.70.1.240.Peer-Reviewed Original ResearchConceptsDefective neuronal migrationGene dosage effectPrimary cellular targetSite of genesisGenetic lociCellular targetsPrimary genetic abnormalityCell deathBergmann glial cellsDosage effectCellular levelGranule cell deathNeuronal migrationCell processesCell genesisNeurological mutantPhenotypic expressionBergmann glial processesGlial cellsCell neuronsGenetic abnormalitiesYoung neuronsWv/wvCerebellum of miceGlial abnormalities