2001
JNK3 contributes to c‐Jun activation and apoptosis but not oxidative stress in nerve growth factor‐deprived sympathetic neurons
Bruckner S, Tammariello S, Kuan C, Flavell R, Rakic P, Estus S. JNK3 contributes to c‐Jun activation and apoptosis but not oxidative stress in nerve growth factor‐deprived sympathetic neurons. Journal Of Neurochemistry 2001, 78: 298-303. PMID: 11461965, DOI: 10.1046/j.1471-4159.2001.00400.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornApoptosisCells, CulturedGenes, junGenotypeIsoenzymesMiceMice, KnockoutMitogen-Activated Protein Kinase 10Mitogen-Activated Protein KinasesNerve Growth FactorNerve Tissue ProteinsNeuronsOxidative StressPhosphorylationProtein-Tyrosine KinasesProto-Oncogene Proteins c-junReverse Transcriptase Polymerase Chain ReactionSuperior Cervical GanglionConceptsJun kinaseC-Jun phosphorylationC-JunDominant negative proteinSympathetic neuronal deathProtein kinase pathwayOxidative stressC-jun inductionC-Jun activationPhosphorylated c-JunApoptotic roleJNK kinaseKinase pathwayNegative proteinJNK isoformsJNK pathwayOverall pathwayNeuronal deathSympathetic neuronsApoptosisJNK3NGF deprivationKinasePhosphorylationCritical role
1999
The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development
Kuan C, Yang D, Roy D, Davis R, Rakic P, Flavell R. The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development. Neuron 1999, 22: 667-676. PMID: 10230788, DOI: 10.1016/s0896-6273(00)80727-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBrainCalcium-Calmodulin-Dependent Protein KinasesCaspasesEmbryonic and Fetal DevelopmentEnzyme ActivationGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicJNK Mitogen-Activated Protein KinasesMiceMice, KnockoutMitogen-Activated Protein Kinase 9Mitogen-Activated Protein KinasesNervous SystemProtein KinasesRhombencephalonConceptsNeural tube closureBrain developmentEmbryonic lethalDouble mutantKinase familyCompound mutantsProtein kinaseCaspase activationPrecocious degenerationJNK2 geneTube closureEarly brain developmentCell deathJNK1Different membersSpecific apoptosisApoptosisMutantsMutant miceJNK2JNK3Mutant forebrainSevere dysregulationFamilyKinase