2001
Caspases and Their Regulation in Apoptosis during Brain Development
Kuan C, Flavell R, Rakic P. Caspases and Their Regulation in Apoptosis during Brain Development. Research And Perspectives In Neurosciences 2001, 75-88. DOI: 10.1007/978-3-662-04333-2_7.Peer-Reviewed Original ResearchJun N-terminal kinasePost-mitotic neuronsMammalian brain developmentCaspase-3 activationCell deathC. elegansCaspase familyDeath gene ced-3Caspase-3Caspase-9Mammalian caspase familyGene ced-3Ectopic cell deathGene ced-9Complex regulation mechanismsNematode C. elegansCell death pathwaysNormal mouse brain developmentN-terminal kinaseBrain developmentCell death cascadeMouse brain developmentCaspase-3 deficiencyCED-3CED-9
2000
Amyloid Beta-Induced Neuronal Death is Bax-Dependent but Caspase-Independent
Selznick L, Zheng T, Flavell R, Rakic P, Roth K. Amyloid Beta-Induced Neuronal Death is Bax-Dependent but Caspase-Independent. Journal Of Neuropathology & Experimental Neurology 2000, 59: 271-279. PMID: 10759182, DOI: 10.1093/jnen/59.4.271.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid Chloromethyl KetonesAmyloid beta-PeptidesAnimalsApoptosisBcl-2-Associated X ProteinCaspase 3Caspase InhibitorsCaspasesCell DeathCells, CulturedCysteine Proteinase InhibitorsDose-Response Relationship, DrugFemaleGlycoproteinsIn Situ Nick-End LabelingMaleMiceMice, KnockoutMicrotubule-Associated ProteinsMicrotubulesNeuronsPaclitaxelProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2TelencephalonConceptsNeuronal deathNeuronal apoptosisCaspase-3 activationTelencephalic neuronsFibrillar amyloid-beta (Abeta) peptidesAbeta-induced neuronal apoptosisAD treatment strategiesAbeta-induced neuronal deathPathogenesis of ADAlzheimer's disease brainEffects of AbetaAmyloid-beta peptideApoptotic nuclear featuresUnderlying pathophysiologyTreatment strategiesDisease brainSenile plaquesNeurotoxic effectsAmyloid betaCalpain inhibitionPharmacological inhibitionBeta peptideNuclear featuresAbetaCaspase-3