Shared and Distinct Brain Regions Targeted for Immediate Early Gene Expression by Ketamine and Psilocybin
Davoudian P, Shao L, Kwan A. Shared and Distinct Brain Regions Targeted for Immediate Early Gene Expression by Ketamine and Psilocybin. ACS Chemical Neuroscience 2023, 14: 468-480. PMID: 36630309, PMCID: PMC9898239, DOI: 10.1021/acschemneuro.2c00637.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainDorsal Raphe NucleusFemaleGenes, Immediate-EarlyHallucinogensKetamineMaleMiceProto-Oncogene Proteins c-fosPsilocybinConceptsC-fos expressionBrain regionsNeural plasticityPlasticity-related gene expressionPrimary visual cortexNumerous brain regionsAnterior cingulate cortexExact brain regionsContribution of receptorsDistinct brain regionsImmediate early gene expressionDorsal rapheGlutamatergic receptorsCA1 subfieldSubanesthetic ketamineFemale miceLocus coeruleusInsular cortexSaline controlsTherapeutic effectPsilocybin administrationBasolateral amygdalaLateral habenulaCingulate cortexVisual cortex