2022
Local connectivity and synaptic dynamics in mouse and human neocortex
Campagnola L, Seeman SC, Chartrand T, Kim L, Hoggarth A, Gamlin C, Ito S, Trinh J, Davoudian P, Radaelli C, Kim MH, Hage T, Braun T, Alfiler L, Andrade J, Bohn P, Dalley R, Henry A, Kebede S, Alice M, Sandman D, Williams G, Larsen R, Teeter C, Daigle TL, Berry K, Dotson N, Enstrom R, Gorham M, Hupp M, Dingman Lee S, Ngo K, Nicovich PR, Potekhina L, Ransford S, Gary A, Goldy J, McMillen D, Pham T, Tieu M, Siverts L, Walker M, Farrell C, Schroedter M, Slaughterbeck C, Cobb C, Ellenbogen R, Gwinn RP, Keene CD, Ko AL, Ojemann JG, Silbergeld DL, Carey D, Casper T, Crichton K, Clark M, Dee N, Ellingwood L, Gloe J, Kroll M, Sulc J, Tung H, Wadhwani K, Brouner K, Egdorf T, Maxwell M, McGraw M, Pom CA, Ruiz A, Bomben J, Feng D, Hejazinia N, Shi S, Szafer A, Wakeman W, Phillips J, Bernard A, Esposito L, D'Orazi FD, Sunkin S, Smith K, Tasic B, Arkhipov A, Sorensen S, Lein E, Koch C, Murphy G, Zeng H, Jarsky T. Local connectivity and synaptic dynamics in mouse and human neocortex. Science 2022, 375: eabj5861. PMID: 35271334, PMCID: PMC9970277, DOI: 10.1126/science.abj5861.Peer-Reviewed Original Research
2021
Connectomic features underlying diverse synaptic connection strengths and subcellular computation
Liu TX, Davoudian PA, Lizbinski KM, Jeanne JM. Connectomic features underlying diverse synaptic connection strengths and subcellular computation. Current Biology 2021, 32: 559-569.e5. PMID: 34914905, PMCID: PMC8825683, DOI: 10.1016/j.cub.2021.11.056.Peer-Reviewed Original ResearchConceptsSomatic postsynaptic potentialsSingle presynaptic spikeElectrical compartmentalizationPostsynaptic potentialsSynapse densityDiverse neuronsSynaptic connectionsSynaptic connection strengthsOlfactory networkPresynaptic spikesNeural tissueDrosophila brainNeuronal biophysicsConnectivity mapsNeuronsBrainSynapsesDopaminergic mechanism underlying reward-encoding of punishment omission during reversal learning in Drosophila
McCurdy LY, Sareen P, Davoudian PA, Nitabach MN. Dopaminergic mechanism underlying reward-encoding of punishment omission during reversal learning in Drosophila. Nature Communications 2021, 12: 1115. PMID: 33602917, PMCID: PMC7893153, DOI: 10.1038/s41467-021-21388-w.Peer-Reviewed Original ResearchConceptsDopaminergic neuronsCholinergic neuronsNeural circuit mechanismsCholinergic relayDopaminergic mechanismsSynaptic excitationSynaptic reconstructionSynaptic inputsVivo functional imagingCircuit mechanismsNeuronsAversive memoryFunctional imagingOdor responsesAversive outcomesReduced activationSuch activationCircuit motifsActivationOutcomesElectric shock punishmentSensory cuesUnexpected omissionShock punishmentBehavioral analysis
2018
Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex
Seeman SC, Campagnola L, Davoudian PA, Hoggarth A, Hage TA, Bosma-Moody A, Baker CA, Lee JH, Mihalas S, Teeter C, Ko AL, Ojemann JG, Gwinn RP, Silbergeld DL, Cobbs C, Phillips J, Lein E, Murphy G, Koch C, Zeng H, Jarsky T. Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex. ELife 2018, 7: e37349. PMID: 30256194, PMCID: PMC6158007, DOI: 10.7554/elife.37349.Peer-Reviewed Original ResearchConceptsRecurrent excitatory connectivityExcitatory connectivityAdult mouse primary visual cortexMouse primary visual cortexHuman cortexLayer 2/3 neuronsClasses of neuronsPrimary visual cortexShort-term depressionBody of evidenceExcitatory neuronsAdult miceVisual cortexSynaptic signalingTwo-photon optogeneticsCell classesCortical networksCortical microcircuitsCortexNeuronsFuture studiesMiceMicrocircuitsSynapses