5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice
Jefferson S, Gregg I, Dibbs M, Liao C, Wu H, Davoudian P, Woodburn S, Wehrle P, Sprouse J, Sherwood A, Kaye A, Pittenger C, Kwan A. 5-MeO-DMT modifies innate behaviors and promotes structural neural plasticity in mice. Neuropsychopharmacology 2023, 48: 1257-1266. PMID: 37015972, PMCID: PMC10354037, DOI: 10.1038/s41386-023-01572-w.Peer-Reviewed Original ResearchConceptsMouse medial frontal cortexEarly phase clinical studiesDendritic spine densityHead-twitch responseDose-dependent increaseStructural neural plasticityMedial frontal cortexSpine densityClinical studiesFrontal cortexLong-term effectsDendritic spinesMental illnessNeural plasticitySpine formationPatient accessSubjective effectsNeural consequencesPotential therapeuticsSerotonergic psychedelicsAnxiety symptomsNeural mechanismsUltrasonic vocalizationsElevated ratesMiceShared and Distinct Brain Regions Targeted for Immediate Early Gene Expression by Ketamine and Psilocybin
Davoudian P, Shao L, Kwan A. Shared and Distinct Brain Regions Targeted for Immediate Early Gene Expression by Ketamine and Psilocybin. ACS Chemical Neuroscience 2023, 14: 468-480. PMID: 36630309, PMCID: PMC9898239, DOI: 10.1021/acschemneuro.2c00637.Peer-Reviewed Original ResearchConceptsC-fos expressionBrain regionsNeural plasticityPlasticity-related gene expressionPrimary visual cortexNumerous brain regionsAnterior cingulate cortexExact brain regionsContribution of receptorsDistinct brain regionsImmediate early gene expressionDorsal rapheGlutamatergic receptorsCA1 subfieldSubanesthetic ketamineFemale miceLocus coeruleusInsular cortexSaline controlsTherapeutic effectPsilocybin administrationBasolateral amygdalaLateral habenulaCingulate cortexVisual cortex