2016
Prognostic Value of Insulin-Like Growth Factor-Binding Protein 7 in Patients with Heart Failure and Preserved Ejection Fraction
Gandhi PU, Chow SL, Rector TS, Krum H, Gaggin HK, McMurray JJ, Zile MR, Komajda M, McKelvie RS, Carson PE, Januzzi JL, Anand IS. Prognostic Value of Insulin-Like Growth Factor-Binding Protein 7 in Patients with Heart Failure and Preserved Ejection Fraction. Journal Of Cardiac Failure 2016, 23: 20-28. PMID: 27317843, DOI: 10.1016/j.cardfail.2016.06.006.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor-binding protein 7Heart failureCause mortalityPrimary outcomeEjection fractionHF eventsInsulin-like growth factorEjection Fraction trialGlomerular filtration rateSigns/symptomsProtein 7Binding protein 7Cardiovascular eventsMultivariable adjustmentSecondary outcomesCardiovascular hospitalizationPrognostic valueFiltration ratePrognostic meritTreatment groupsGrowth factorOutcomesFurther studiesPatientsEGFR
2015
Diagnostic and Prognostic Utility of Procalcitonin in Patients Presenting to the Emergency Department with Dyspnea
Alba GA, Truong QA, Gaggin HK, Gandhi PU, De Berardinis B, Magrini L, Bajwa EK, Di Somma S, Januzzi JL, Network G. Diagnostic and Prognostic Utility of Procalcitonin in Patients Presenting to the Emergency Department with Dyspnea. The American Journal Of Medicine 2015, 129: 96-104.e7. PMID: 26169892, DOI: 10.1016/j.amjmed.2015.06.037.Peer-Reviewed Original ResearchConceptsDiagnosis of pneumoniaNet reclassification improvementEmergency departmentHeart failurePrognostic valueReclassification improvementEmergency department patientsIndependent prognostic informationAccuracy of procalcitoninUrban emergency departmentAccurate diagnostic markerAcute dyspneaClinician certaintyElevated procalcitoninSerum procalcitoninDyspneic patientsProspective cohortSecondary outcomesDepartment patientsProcalcitonin concentrationsFatal outcomeNatriuretic peptidePCT valuesPrognostic utilityPatient populationAnalysis of BAG3 plasma concentrations in patients with acutely decompensated heart failure
Gandhi PU, Gaggin HK, Belcher AM, Harisiades JE, Basile A, Falco A, Rosati A, Piscione F, Januzzi JL, Turco MC. Analysis of BAG3 plasma concentrations in patients with acutely decompensated heart failure. Clinica Chimica Acta 2015, 445: 73-78. PMID: 25753466, DOI: 10.1016/j.cca.2015.02.048.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAdaptor Proteins, Signal TransducingAdrenomedullinAgedAged, 80 and overApoptosis Regulatory ProteinsAtrial Natriuretic FactorBiomarkersErbB ReceptorsFemaleGene ExpressionHeart FailureHeart VentriclesHumansInterleukin-1 Receptor-Like 1 ProteinKidney Function TestsMalePrognosisReceptors, Cell SurfaceStroke VolumeSurvival AnalysisConceptsLeft ventricular ejection fractionBcl-2-associated athanogene 3Heart failureNatriuretic peptidePlasma concentrationsCox proportional hazards regressionWorse renal functionVentricular ejection fractionKaplan-Meier analysisProportional hazards regressionSignificant mortality predictorsCox proportional hazardsGenesis of cardiomyopathyHF prognosisHF patientsBaseline characteristicsPrimary endpointRenal functionEjection fractionHazards regressionMortality predictorsVital statusPrognostic valuePatientsProportional hazards