Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS
Guo C, Che X, Briese T, Ranjan A, Allicock O, Yates R, Cheng A, March D, Hornig M, Komaroff A, Levine S, Bateman L, Vernon S, Klimas N, Montoya J, Peterson D, Lipkin W, Williams B. Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS. Cell Host & Microbe 2023, 31: 288-304.e8. PMID: 36758522, PMCID: PMC10183837, DOI: 10.1016/j.chom.2023.01.004.Peer-Reviewed Original ResearchConceptsME/CFSFaecalibacterium prausnitziiMyalgic encephalomyelitis/chronic fatigue syndromeFecal short-chain fatty acidsChronic fatigue syndromeShort-chain fatty acidsGut microbiome diversityGut dysbiosisGastrointestinal disturbancesTherapeutic trialsFatigue severityFatigue syndromeOrthostatic intoleranceValidation cohortHealthy controlsCognitive dysfunctionFatigue symptomsGut microbiomeDiverse cohortButyrate producersHuman gutPossible targetsEubacterium rectaleCohortMulti-omics analysis