Thromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia.
Ment L, Stewart W, Petroff O, Duncan C. Thromboxane synthesis inhibitor in a beagle pup model of perinatal asphyxia. Stroke 1989, 20: 809-814. PMID: 2728050, DOI: 10.1161/01.str.20.6.809.Peer-Reviewed Original ResearchConceptsCerebral blood flowThromboxane synthesis inhibitorBlood flowPerinatal asphyxiaSynthesis inhibitorCGS 13080Intraventricular hemorrhageLactate levelsCerebral regionsHigh incidenceMetabolic alterationsWhite matterLactate concentrationAsphyxiaBrain extractsInsultPhosphocreatine concentrationPupsSalineInhibitorsHemorrhageProstaglandinsMedullaThe Effect of Diazepam on Neonatal Seizure: In Vivo 31P and 1H NMR Study
Young R, Chen B, Petroff O, Gore J, Cowan B, Novotny E, Wong M, Zuckerman K. The Effect of Diazepam on Neonatal Seizure: In Vivo 31P and 1H NMR Study. Pediatric Research 1989, 25: 27-31. PMID: 2919113, DOI: 10.1203/00006450-198901000-00006.Peer-Reviewed Original ResearchConceptsBrain lactateBrain high-energy phosphatesArrest of seizuresFlurothyl-induced seizuresCerebral blood flowNormalization of EEGEffects of diazepamVivo 31P nuclear magnetic resonance spectroscopyHigh-energy phosphatesElectrographic seizuresNeonatal seizuresNeonatal dogsPostictal periodBrain pHBaseline valuesBlood flowBrain phosphocreatineMetabolic recoveryProlonged elevationSeizuresSustained increaseVivo 31PRapid returnDiazepamEnergy phosphates