1989
The Effect of Diazepam on Neonatal Seizure: In Vivo 31P and 1H NMR Study
Young R, Chen B, Petroff O, Gore J, Cowan B, Novotny E, Wong M, Zuckerman K. The Effect of Diazepam on Neonatal Seizure: In Vivo 31P and 1H NMR Study. Pediatric Research 1989, 25: 27-31. PMID: 2919113, DOI: 10.1203/00006450-198901000-00006.Peer-Reviewed Original ResearchConceptsBrain lactateBrain high-energy phosphatesArrest of seizuresFlurothyl-induced seizuresCerebral blood flowNormalization of EEGEffects of diazepamVivo 31P nuclear magnetic resonance spectroscopyHigh-energy phosphatesElectrographic seizuresNeonatal seizuresNeonatal dogsPostictal periodBrain pHBaseline valuesBlood flowBrain phosphocreatineMetabolic recoveryProlonged elevationSeizuresSustained increaseVivo 31PRapid returnDiazepamEnergy phosphates
1988
1H nuclear magnetic resonance spectroscopy study of neonatal hypoglycemia
Petroff O, Young R, Cowan B, Novotny E. 1H nuclear magnetic resonance spectroscopy study of neonatal hypoglycemia. Pediatric Neurology 1988, 4: 31-34. PMID: 3233106, DOI: 10.1016/0887-8994(88)90021-5.Peer-Reviewed Original ResearchConceptsHigh-energy phosphatesBrain high-energy phosphatesBrain energy stateHypoglycemic brain damageInsulin-induced hypoglycemiaExcitatory amino acidsHypoglycemic brain injuryBrain tissue injuryMagnetic resonance spectroscopy studyAdult experimental animalsBrain glucose contentNeonatal hypoglycemiaExcitatory neurotransmitterInhibitory neurotransmitterMechanisms of resistanceNeonatal dogsBrain damageBrain injuryBrain glutamateTissue injuryEnergy failureNeonatal animalsGABA concentrationExperimental animalsHypoglycemia