2013
Incidence and prognostic impact of KRAS and BRAF mutation in patients undergoing liver surgery for colorectal metastases
Karagkounis G, Torbenson MS, Daniel HD, Azad NS, Diaz LA, Donehower RC, Hirose K, Ahuja N, Pawlik TM, Choti MA. Incidence and prognostic impact of KRAS and BRAF mutation in patients undergoing liver surgery for colorectal metastases. Cancer 2013, 119: 4137-4144. PMID: 24104864, PMCID: PMC3967132, DOI: 10.1002/cncr.28347.Peer-Reviewed Original ResearchConceptsColorectal liver metastasesSurgical therapyBRAF mutationsLiver metastasesKRAS statusPrognostic impactKRAS mutationsMolecular biomarkersThird of patientsRecurrence-free survivalKRAS gene mutationsPrognostic determinantsColorectal metastasesSurgical cohortWorse survivalClinicopathologic factorsIndependent predictorsCancer surgeryClinicopathologic featuresTumor numberPrognostic significanceBRAF analysisColorectal cancerLiver surgeryLower incidenceDNA Methylation Biomarkers of Stool and Blood for Early Detection of Colon Cancer
Hong L, Ahuja N. DNA Methylation Biomarkers of Stool and Blood for Early Detection of Colon Cancer. Genetic Testing And Molecular Biomarkers 2013, 17: 401-406. PMID: 23406208, DOI: 10.1089/gtmb.2012.0478.Peer-Reviewed Original ResearchConceptsColon cancerDNA methylation markersEarly detectionMethylation markersStool-based testsCurrent screening testsScreening complianceColorectal cancerGeneral populationDNA methylation biomarkersClinical availabilityScreening testCancerClinical researchHigh efficacyBloodMethylation biomarkersStoolMarkersMore investigationEarly stagesColonoscopyPatientsMortalityDisease
2012
A pressure cooking-based DNA extraction from archival formalin-fixed, paraffin-embedded tissue
Chung JY, Yi JM, Xie R, Brown V, Lee O, Ahuja N, Braunschweig T, Hewitt SM. A pressure cooking-based DNA extraction from archival formalin-fixed, paraffin-embedded tissue. Analytical Biochemistry 2012, 425: 128-134. PMID: 22449494, PMCID: PMC3358925, DOI: 10.1016/j.ab.2012.03.012.Peer-Reviewed Original Research