2016
Epigenetic therapy in gastrointestinal cancer: the right combination
Abdelfatah E, Kerner Z, Nanda N, Ahuja N. Epigenetic therapy in gastrointestinal cancer: the right combination. Therapeutic Advances In Gastroenterology 2016, 9: 560-579. PMID: 27366224, PMCID: PMC4913338, DOI: 10.1177/1756283x16644247.Peer-Reviewed Original ResearchDNA methyltransferaseEpigenetic dysregulationEpigenetic drugsEpigenetic therapyCpG island methylator phenotypeDeoxyribonucleic acid methylationChromatin remodelingHistone modificationsCancer epigenomeEpigenetic reprogrammingWidespread epigenetic dysregulationCancer epigeneticsEpigenetic targetsCancer stem cellsHistone deacetylase inhibitorsMolecular biologyAcid methylationStem cellsDeacetylase inhibitorsDevelopment of drugsEpigeneticsGenetic mutationsMethylator phenotypeChemo resistanceEpigenetic sensitization
2010
The role of oncogenes in gastrointestinal cancer.
Pappou EP, Ahuja N. The role of oncogenes in gastrointestinal cancer. Gastrointestinal Cancer Research : GCR 2010, s2-s15. PMID: 21472044, PMCID: PMC3047044.Peer-Reviewed Original ResearchActive chromatin domainsComplex regulatory cascadeGrowth regulatory genesProducts of oncogenesRole of oncogenesChromatin remodelersChromatin domainsRegulatory cascadeOncogene researchTranscription factorsChimeric geneGrowth factor receptorSignal transducerCell cycleMolecular mechanismsProtein productsApoptosis regulatorInappropriate expressionDifferent promotersMolecular biologyOncogene activationGenesNormal developmentPoint mutationsActive oncogenes