2013
Influence of racial differences on outcomes after thrombolytic therapy in acute ischemic stroke
Mishra NK, Mandava P, Chen C, Grotta J, Lees KR, Kent TA, collaboration V. Influence of racial differences on outcomes after thrombolytic therapy in acute ischemic stroke. International Journal Of Stroke 2013, 9: 613-617. PMID: 24148895, DOI: 10.1111/ijs.12162.Peer-Reviewed Original ResearchConceptsTissue plasminogen activatorBaseline National InstitutesHealth Stroke ScaleNon-Caucasian patientsPlasminogen activatorStroke ScaleNational InstituteRace-EthnicityNon-thrombolysed patientsStroke III TrialRace-ethnicity groupsNeuroprotection trialsIII trialsDiabetes statusFunctional outcomeImproved outcomesPatientsNeurological disordersCaucasian populationDifferential responseEthnicity groupsOutcomesCaucasiansOddsTrialsPostthrombolysis outcomes in acute ischemic stroke patients of Asian race‐ethnicity
Mishra NK, Chan BP, Teoh H, Meng C, Lees KR, Chen C, Sharma VK, collaboration F. Postthrombolysis outcomes in acute ischemic stroke patients of Asian race‐ethnicity. International Journal Of Stroke 2013, 8: 95-99. PMID: 23490069, DOI: 10.1111/ijs.12012.Peer-Reviewed Original ResearchConceptsVirtual International Stroke Trials ArchiveThrombolytic therapyStroke patientsAsian patientsHealth Stroke Scale scorePropensity score-matched patientsAcute ischemic stroke patientsTissue plasminogen activator therapyAsian stroke patientsBaseline National InstitutesPropensity-matched cohortStroke Scale scoreIschemic stroke patientsProportional odds logistic regression analysisPlasminogen activator therapyNational University HospitalLogistic regression analysisNational InstituteRace-ethnic differencesNeurological outcomeRankin scoreThrombolyzed patientsPropensity matchingTertiary centerActivator therapyThrombolysis in Stroke Despite Contraindications or Warnings?
Frank B, Grotta JC, Alexandrov AV, Bluhmki E, Lyden P, Meretoja A, Mishra NK, Shuaib A, Wahlgren NG, Weimar C, Lees KR. Thrombolysis in Stroke Despite Contraindications or Warnings? Stroke 2013, 44: 727-733. PMID: 23391774, DOI: 10.1161/strokeaha.112.674622.Peer-Reviewed Original ResearchConceptsHealth Stroke ScoreAlteplase treatmentStroke ScoreOdds ratioBaseline National InstitutesIntravenous alteplase treatmentPretreatment National InstitutesSingle antiplatelet agentTrial selection criteriaAcute ischemic strokeIschemic stroke patientsProportional odds logistic regression analysisSubgroup of patientsAdjusted odds ratioCommon clinical situationsNational InstituteLogistic regression analysisInternational normalizedIntravenous thrombolysisOral anticoagulationPrior strokeComprehensive retrospective analysisIschemic strokeRankin ScaleUntreated patients
2011
Low Body Temperature Does Not Compromise the Treatment Effect of Alteplase
Lees JS, Mishra NK, Saini M, Lyden PD, Shuaib A. Low Body Temperature Does Not Compromise the Treatment Effect of Alteplase. Stroke 2011, 42: 2618-2621. PMID: 21757664, DOI: 10.1161/strokeaha.110.611210.Peer-Reviewed Original ResearchConceptsBaseline body temperatureAcute ischemic strokeRankin Scale scoreIschemic strokeAlteplase treatmentBaseline severityBody temperatureScale scoreVirtual International Stroke Trials ArchiveRankin Scale distributionsBaseline National InstitutesHealth Stroke ScaleIschemic stroke modelTreatment effectsStroke ScaleThrombolytic therapyImproved outcomesTherapeutic effectTreatment responseStroke modelTreatment groupsAlteplaseCochran-MantelLow body temperatureStrokeHome Time Is Extended in Patients With Ischemic Stroke Who Receive Thrombolytic Therapy
Mishra NK, Shuaib A, Lyden P, Diener HC, Grotta J, Davis S, Davalos A, Ashwood T, Wasiewski W, Lees KR. Home Time Is Extended in Patients With Ischemic Stroke Who Receive Thrombolytic Therapy. Stroke 2011, 42: 1046-1050. PMID: 21350199, DOI: 10.1161/strokeaha.110.601302.Peer-Reviewed Original ResearchConceptsHealth Stroke ScaleBaseline National InstitutesPresence of diabetesAcute stroke trialsStroke ScaleRankin ScaleBarthel IndexStroke trialsNational InstituteDay 90Use of alteplaseHome timeCountry of enrollmentLevel of consciousnessAlteplase useIschemic strokeStroke onsetIschemic lesionsThrombolytic therapyPatient enrollmentBaseline severityOrdinal logistic regressionTreatment responsivenessOutcome measuresAnalysis of covariance
2010
Influence of Age on Outcome From Thrombolysis in Acute Stroke
Mishra NK, Diener HC, Lyden PD, Bluhmki E, Lees KR. Influence of Age on Outcome From Thrombolysis in Acute Stroke. Stroke 2010, 41: 2840-2848. PMID: 21030710, DOI: 10.1161/strokeaha.110.586206.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeHealth scale scoresControl subjectsIschemic strokeInfluence of ageScale scoreBaseline National InstitutesRankin Scale scoreNational InstituteLimited trial dataNeuroprotection trialsRankin scoreThrombolysis treatmentAcute strokeYounger patientsAge decilesPoor outcomeBaseline severityImproved outcomesPatientsHaenszel testTrial dataCochran-MantelThrombolysisLogistic regressionThrombolysis Is Associated With Consistent Functional Improvement Across Baseline Stroke Severity
Mishra NK, Lyden P, Grotta JC, Lees KR. Thrombolysis Is Associated With Consistent Functional Improvement Across Baseline Stroke Severity. Stroke 2010, 41: 2612-2617. PMID: 20947852, DOI: 10.1161/strokeaha.110.589317.Peer-Reviewed Original ResearchConceptsRankin Scale score distributionBaseline stroke severityBaseline NIHSSAssociation of treatmentScale score distributionStroke severityOdds ratioModified Rankin scale score distributionCochran-MantelVirtual International Stroke Trials ArchiveBaseline National InstitutesConsistent functional improvementsHealth Stroke ScaleProportional odds logistic regression analysisClinical trial enrollmentLogistic regression analysisNeuroprotection trialsUntreated comparatorsStroke ScaleTrial enrollmentAdjusted outcomesThrombolysed patientsNonrandomized comparisonBaseline severityFunctional improvementComparison of Outcomes Following Thrombolytic Therapy Among Patients With Prior Stroke and Diabetes in the Virtual International Stroke Trials Archive (VISTA)
Mishra NK, Davis SM, Kaste M, Lees KR, . Comparison of Outcomes Following Thrombolytic Therapy Among Patients With Prior Stroke and Diabetes in the Virtual International Stroke Trials Archive (VISTA). Diabetes Care 2010, 33: 2531-2537. PMID: 20843977, PMCID: PMC2992183, DOI: 10.2337/dc10-1125.Peer-Reviewed Original ResearchConceptsVirtual International Stroke Trials ArchivePrior strokeUse of alteplaseBaseline National InstitutesHealth Stroke ScaleProportional odds logistic regression analysisInfluence of diabetesInteraction of diabetesComparison of outcomesLogistic regression analysisConcomitant diabetesEligible patientsNeurological outcomeStroke ScaleIschemic strokeThrombolytic treatmentThrombolytic therapyThrombolysed patientsFunctional outcomeControl subjectsOutcome measuresPatientsDiabetesHaenszel testCochran-Mantel