2009
Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice
Xiao X, Ma B, Dong B, Zhao P, Tai N, Chen L, Wong FS, Wen L. Cellular and humoral immune responses in the early stages of diabetic nephropathy in NOD mice. Journal Of Autoimmunity 2009, 32: 85-93. PMID: 19200691, DOI: 10.1016/j.jaut.2008.12.003.Peer-Reviewed Original ResearchConceptsDiabetic NOD miceNOD miceDiabetic nephropathyDiabetic miceNon-diabetic NOD miceNon-obese diabetic (NOD) miceDuration of diabetesUrinary albumin excretionAdditional therapeutic targetsHumoral immune responseAlbumin excretionAutoimmune diabetesDendritic cellsDiabetes onsetImmune changesKidney weightIgG depositsHumoral immunityT cellsImmune responseNephropathyComplement C3Therapeutic targetB cellsImmune system
2007
Identification of a cis-acting element of human dihydrofolate reductase mRNA
Tai N, Schmitz JC, Chen TM, O’Neill M, Chu E. Identification of a cis-acting element of human dihydrofolate reductase mRNA. Biochemical And Biophysical Research Communications 2007, 369: 795-800. PMID: 18045573, DOI: 10.1016/j.bbrc.2007.09.044.Peer-Reviewed Original Research
2004
Characterization of a cis-acting regulatory element in the protein-coding region of human dihydrofolate reductase mRNA
Ningwen T, SCHMITZ JC, CHEN TM, Edward C. Characterization of a cis-acting regulatory element in the protein-coding region of human dihydrofolate reductase mRNA. Biochemical Journal 2004, 378: 999-1006. PMID: 14664697, PMCID: PMC1224025, DOI: 10.1042/bj20031396.Peer-Reviewed Original Research
2002
Thymidylate synthase as a translational regulator of cellular gene expression
Liu J, Schmitz JC, Lin X, Tai N, Yan W, Farrell M, Bailly M, Chen T, Chu E. Thymidylate synthase as a translational regulator of cellular gene expression. Biochimica Et Biophysica Acta 2002, 1587: 174-182. PMID: 12084459, DOI: 10.1016/s0925-4439(02)00080-7.Peer-Reviewed Original ResearchConceptsTranslational regulatorCell cycleRNA binding proteinCellular gene expressionProcess of apoptosisTumor suppressor geneFolate-dependent enzymesTranslational repressionCellular mRNAsCognate mRNATranscription factorsMRNA interactionsMyc familyVivo model systemsGene expressionTS proteinCellular resistanceSuppressor geneBinding proteinMolecular elementsP53 tumor suppressor geneFunctional consequencesAbility of TSAutoregulatory controlProtein