2017
A translational approach for NMDA receptor profiling as a vulnerability biomarker for depression and schizophrenia
Gunduz‐Bruce H, Kenney J, Changlani S, Peixoto A, Gueorguieva R, Leone C, Stachenfeld N. A translational approach for NMDA receptor profiling as a vulnerability biomarker for depression and schizophrenia. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2017, 102: 587-597. PMID: 28294453, DOI: 10.1113/ep086212.Peer-Reviewed Original ResearchConceptsSubgroup of patientsHealthy control subjectsNMDA receptorsControl subjectsDepressed patientsAVP releaseAnimal studiesSchizophrenic subjectsTranslational approachVivo evidenceRecent clinical trialsNMDA receptor functionPlasma arginine vasopressin concentrationNMDA receptor activityHypertonic saline infusionNMDA antagonist ketamineArginine vasopressin concentrationHypertonic salineInverse associationClinical trialsHealthy controlsSaline infusionGlutamate signalingSchizophrenic patientsVasopressin concentration
2014
Hormonal Changes During Menopause and the Impact on Fluid Regulation
Stachenfeld NS. Hormonal Changes During Menopause and the Impact on Fluid Regulation. Reproductive Sciences 2014, 21: 555-561. PMID: 24492487, PMCID: PMC3984489, DOI: 10.1177/1933719113518992.Peer-Reviewed Original ResearchConceptsHormone therapySodium retentionMenopausal womenFluid regulationCardiovascular functionAldosterone-mediated sodium retentionRisk of hyponatremiaBlood pressure responseFemale reproductive hormonesFluid-regulating hormonesBody fluid volumeRisk of dehydrationBody fluid regulationEstrogen therapyHypervolemic hyponatremiaCardiovascular riskEstradiol effectsSodium loadProgesterone exposureMineralocorticoid receptorProgestogen exposureReproductive hormonesReproductive surgeryHormonal changesDistal tubules
2009
Sex hormone effects on body fluid and sodium regulation in women with and without exercise-associated hyponatremia
Stachenfeld NS, Taylor HS. Sex hormone effects on body fluid and sodium regulation in women with and without exercise-associated hyponatremia. Journal Of Applied Physiology 2009, 107: 864-872. PMID: 19556454, DOI: 10.1152/japplphysiol.91211.2008.Peer-Reviewed Original ResearchConceptsExercise-associated hyponatremiaSodium lossGonadotropin-releasing hormone antagonistPeak oxygen consumptionMin of exerciseHistory of hyponatremiaHigh water intakeGnRH-antFluid retentionHormone antagonistProgesterone exposureEndurance exerciseDay 4Hormone effectsDay 13HyponatremiaSodium regulationHormone conditionsWomenHypoWater intakeOxygen consumptionProgesteroneExerciseLittle fall
2008
Sex Hormone Effects on Body Fluid Regulation
Stachenfeld NS. Sex Hormone Effects on Body Fluid Regulation. Exercise And Sport Sciences Reviews 2008, 36: 152-159. PMID: 18580296, PMCID: PMC2849969, DOI: 10.1097/jes.0b013e31817be928.Peer-Reviewed Original Research
2007
Exercise and Fluid Replacement
Sawka M, Burke L, Eichner E, Maughan R, Montain S, Stachenfeld N. Exercise and Fluid Replacement. Medicine & Science In Sports & Exercise 2007, 39: 377-390. PMID: 17277604, DOI: 10.1249/mss.0b013e31802ca597.Peer-Reviewed Original ResearchMeSH KeywordsExerciseFluid TherapyHumansMotor ActivityNutrition AssessmentSportsTime FactorsWater-Electrolyte BalanceConceptsFluid replacementElectrolyte deficitsPlasma electrolyte levelsUrine outputFluid intakeNormal mealPhysical activityElectrolyte balanceElectrolyte levelsBody weightAppropriate hydrationNormal levelsFluid absorptionPosition standReplacement programSweat rateExerciseElectrolyte contentDeficitsConsiderable variabilityBeveragesIndividualsIntakeActivity
2002
Estrogen effects on osmotic regulation of AVP and fluid balance
Stachenfeld NS, Keefe DL. Estrogen effects on osmotic regulation of AVP and fluid balance. AJP Endocrinology And Metabolism 2002, 283: e711-e721. PMID: 12217888, DOI: 10.1152/ajpendo.00192.2002.Peer-Reviewed Original ResearchConceptsHormone treatmentEstrogen effectsPlasma renin activityFree water clearanceEnd of recoveryIntrarenal effectsRenal sensitivityRenin activitySodium excretionFractional excretionAVP increaseSodium retentionFluid retentionLeuprolide acetateWater clearanceEndogenous estrogensAldosterone stimulationFluid balanceGnRHaNaCl infusionPg/EstrogenAVPProgesteroneExcretion
2001
Progesterone does not alter osmotic regulation of AVP
Calzone W, Silva C, Keefe D, Stachenfeld N. Progesterone does not alter osmotic regulation of AVP. AJP Regulatory Integrative And Comparative Physiology 2001, 281: r2011-r2020. PMID: 11705788, DOI: 10.1152/ajpregu.2001.281.6.r2011.Peer-Reviewed Original ResearchMeSH KeywordsAdultArginine VasopressinBlood VolumeEstradiolFemaleFollicular PhaseHumansHydrocortisoneLuteal PhaseMenstrual CycleProgesteroneThirstWater-Electrolyte BalanceConceptsHypertonic saline infusionLuteal phaseOral contraceptivesFollicular phaseOsmotic thresholdThirst onsetRenal free water clearanceLow osmotic thresholdFree water clearancePlasma AVP concentrationArginine vasopressin releaseBaseline plasma osmolalityBody water balanceMenstrual cycleMidluteal phaseWater clearanceSaline infusionAVP releaseAVP concentrationMenstrual phaseVasopressin releaseFluid balanceOC treatmentThirst responseCrossover designSelected Contribution: Sex differences in osmotic regulation of AVP and renal sodium handling
Stachenfeld N, Splenser A, Calzone W, Taylor M, Keefe D. Selected Contribution: Sex differences in osmotic regulation of AVP and renal sodium handling. Journal Of Applied Physiology 2001, 91: 1893-1901. PMID: 11568177, DOI: 10.1152/jappl.2001.91.4.1893.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlgorithmsArginine VasopressinBlood VolumeBody WaterFemaleGenomeHemodynamicsHemoglobinsHumansKidneyMaleReninSex CharacteristicsSodiumWater-Electrolyte BalanceConceptsSystolic blood pressureBlood pressureMenstrual phaseBasal plasma AVP concentrationGreater systolic blood pressurePressure-natriuresis curveRenal sodium handlingPlasma osmolalityPlasma AVP concentrationMin of restMidluteal menstrual phasesBasal plasma osmolalitySex differencesSodium handlingPulse pressureBody wtAVP concentrationAVP releaseNaCl infusionHormone responseMenWomenGreater sensitivityBody waterOsmolality
1998
Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women
Stachenfeld N, Dipietro L, Palter S, Nadel E. Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women. American Journal Of Physiology 1998, 274: r187-r195. PMID: 9458917, DOI: 10.1152/ajpregu.1998.274.1.r187.Peer-Reviewed Original ResearchConceptsMin of drinkingPg/Body water balanceHypertonic salineFractional sodium excretionPlasma aldosterone concentrationRenal sodium reabsorptionFree water clearancePlasma estradiol concentrationsHypertonic saline infusionHigh E2 statesWater ad libitumMosmol/kgH2OAldosterone concentrationPostmenopausal womenSodium excretionPlacebo administrationUrine outputAVP secretionSodium reabsorptionFluid retentionE2 treatmentEstradiol concentrationsWater clearanceSaline infusion
1996
Thirst and fluid regulatory responses to hypertonicity in older adults
Stachenfeld N, Mack G, Takamata A, DiPietro L, Nadel E. Thirst and fluid regulatory responses to hypertonicity in older adults. American Journal Of Physiology 1996, 271: r757-r765. PMID: 8853401, DOI: 10.1152/ajpregu.1996.271.3.r757.Peer-Reviewed Original ResearchFluid balance and renal response following dehydrating exercise in well-trained men and women
Stachenfeld N, Gleim G, Zabetakis P, Nicholas J. Fluid balance and renal response following dehydrating exercise in well-trained men and women. European Journal Of Applied Physiology 1996, 72: 468-477. PMID: 8925818, DOI: 10.1007/bf00242277.Peer-Reviewed Original ResearchMeSH KeywordsAdultAldosteroneExerciseFemaleHumansKidneyMaleOsmolar ConcentrationReninSex FactorsTime FactorsWater-Electrolyte BalanceConceptsPlasma renin activityEnd of exerciseSodium handlingMin postexerciseEarly recoveryFluid balanceLow plasma renin activityRenal free water clearancePlasma volumeFractional sodium excretionPlasma osmolalityFree water clearanceOverall fluid balanceMin of recoveryFluid-regulating hormonesRenin activitySodium excretionSerum aldosteroneNorepinephrine concentrationsRenal responseWater clearanceRenal waterAnaerobic thresholdWater reabsorptionWomen
1995
Body temperature modification of osmotically induced vasopressin secretion and thirst in humans
Takamata A, Mack G, Stachenfeld N, Nadel E. Body temperature modification of osmotically induced vasopressin secretion and thirst in humans. American Journal Of Physiology 1995, 269: r874-r880. PMID: 7485606, DOI: 10.1152/ajpregu.1995.269.4.r874.Peer-Reviewed Original Research