2015
Sex hormone effects on autonomic mechanisms of thermoregulation in humans
Charkoudian N, Stachenfeld N. Sex hormone effects on autonomic mechanisms of thermoregulation in humans. Autonomic Neuroscience 2015, 196: 75-80. PMID: 26674572, DOI: 10.1016/j.autneu.2015.11.004.ChaptersConceptsAutonomic mechanismsReproductive hormonesBody temperatureCentral autonomic nucleusHeat dissipation responsePolycystic ovary syndromeFemale reproductive hormonesPeripheral blood vesselsInfluence of progesteroneSkin blood flowAutonomic nucleiOvary syndromePeripheral effectsMenstrual cycleHormone levelsBlood flowHormone effectsLow body temperatureBlood vesselsEstrogenHigh body temperatureRecent evidenceMenopauseProgesteroneThermoregulatory responses
2009
Sex hormone effects on body fluid and sodium regulation in women with and without exercise-associated hyponatremia
Stachenfeld NS, Taylor HS. Sex hormone effects on body fluid and sodium regulation in women with and without exercise-associated hyponatremia. Journal Of Applied Physiology 2009, 107: 864-872. PMID: 19556454, DOI: 10.1152/japplphysiol.91211.2008.Peer-Reviewed Original ResearchConceptsExercise-associated hyponatremiaSodium lossGonadotropin-releasing hormone antagonistPeak oxygen consumptionMin of exerciseHistory of hyponatremiaHigh water intakeGnRH-antFluid retentionHormone antagonistProgesterone exposureEndurance exerciseDay 4Hormone effectsDay 13HyponatremiaSodium regulationHormone conditionsWomenHypoWater intakeOxygen consumptionProgesteroneExerciseLittle fallFEMALE REPRODUCTIVE HORMONE EFFECTS ON SKIN VESSEL ADRENERGIC RESPONSIVENESS IN WOMEN WITH LOW AND HIGH ORTHOSTATIC TOLERANCE.
Stachenfeld N, Hinds K, Taylor H. FEMALE REPRODUCTIVE HORMONE EFFECTS ON SKIN VESSEL ADRENERGIC RESPONSIVENESS IN WOMEN WITH LOW AND HIGH ORTHOSTATIC TOLERANCE. The FASEB Journal 2009, 23: 968.2-968.2. DOI: 10.1096/fasebj.23.1_supplement.968.2.Peer-Reviewed Original ResearchHigh orthostatic toleranceCumulative stress indexL-NMMAAdrenergic responsivenessOrthostatic toleranceLower body negative pressureReproductive hormone effectsNitric oxide mechanismBody negative pressureLaser Doppler flowmetrySkin blood flowStimulus-response curvesNorepinephrine infusionHormone antagonistDoppler flowmetryBlood flowDay 4Hormone effectsDay 13GnRHProgesteroneOxide mechanismWomenEstradiolResponsiveness
2005
Progesterone increases plasma volume independent of estradiol
Stachenfeld NS, Taylor HS. Progesterone increases plasma volume independent of estradiol. Journal Of Applied Physiology 2005, 98: 1991-1997. PMID: 15718411, DOI: 10.1152/japplphysiol.00031.2005.Peer-Reviewed Original ResearchConceptsTranscapillary escape ratePlasma concentrationsPlasma volumeGnRH antagonistECF volumeAdequate plasma volumeAldosterone system stimulationPlasma renin activityGonadotropin-releasing hormoneExtracellular fluid volumeRenin activitySerum aldosteroneAng IIBlood pressureEstrogen administrationSystem stimulationDay 2Day 5Pg/Day 13Fluid regulationPV expansionFluid volumeIndependent effectsProgesterone
2004
Responses to a Saline Load in Gonadotropin-Releasing Hormone Antagonist-Pretreated Premenopausal Women Receiving Progesterone or Estradiol-Progesterone Therapy
Stachenfeld NS, Keefe DL, Taylor HS. Responses to a Saline Load in Gonadotropin-Releasing Hormone Antagonist-Pretreated Premenopausal Women Receiving Progesterone or Estradiol-Progesterone Therapy. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 386-394. PMID: 15486051, DOI: 10.1210/jc.2004-0941.Peer-Reviewed Original ResearchConceptsSodium regulationOvarian hyperstimulation syndromeEffects of estradiolMin of restImportant clinical implicationsHyperstimulation syndromeSodium excretionGnRH antagonistRenal diseaseSodium loadIsotonic salineClinical implicationsSyndromeReproductive syndromeSubjectsPreeclampsiaGnRHGroupEstradiolProgesteroneAntagonistExcretionDiseaseAdministrationSaline
2003
Effects of estrogen and progesterone administration on extracellular fluid
Stachenfeld NS, Taylor HS. Effects of estrogen and progesterone administration on extracellular fluid. Journal Of Applied Physiology 2003, 96: 1011-1018. PMID: 14660504, DOI: 10.1152/japplphysiol.01032.2003.Peer-Reviewed Original ResearchConceptsGnRH antagonist administrationExtracellular fluid volumeGnRH antagonistEffects of estrogenAntagonist administrationPlasma volumeTranscapillary escape rateGonadotropin-releasing hormoneExtracellular fluidHealthy womenProgesterone administrationECFV expansionGanirelix acetateEndogenous estrogensStrong negative predictorDay 2Day 5Pg/AntagonistEstrogenDay 12Plasma compartmentCapillary endotheliumAdministrationProgesterone
2002
Estrogen effects on osmotic regulation of AVP and fluid balance
Stachenfeld NS, Keefe DL. Estrogen effects on osmotic regulation of AVP and fluid balance. AJP Endocrinology And Metabolism 2002, 283: e711-e721. PMID: 12217888, DOI: 10.1152/ajpendo.00192.2002.Peer-Reviewed Original ResearchConceptsHormone treatmentEstrogen effectsPlasma renin activityFree water clearanceEnd of recoveryIntrarenal effectsRenal sensitivityRenin activitySodium excretionFractional excretionAVP increaseSodium retentionFluid retentionLeuprolide acetateWater clearanceEndogenous estrogensAldosterone stimulationFluid balanceGnRHaNaCl infusionPg/EstrogenAVPProgesteroneExcretion
2000
Estrogen modifies the temperature effects of progesterone
Stachenfeld N, Silva C, Keefe D. Estrogen modifies the temperature effects of progesterone. Journal Of Applied Physiology 2000, 88: 1643-1649. PMID: 10797125, DOI: 10.1152/jappl.2000.88.5.1643.Peer-Reviewed Original ResearchConceptsOral contraceptive administrationFollicular phaseLuteal phaseContraceptive administrationBaseline esophageal temperatureOC PFollicular phase levelsMin of exerciseMidluteal menstrual phasesProgestin administrationCore temperature thresholdMenstrual phaseDegrees C. SubjectsEsophageal temperatureEstrogenC. SubjectsAdministrationPassive heatingProgestinsCore temperatureExercisePrevious findingsProgesteronePhase levelsMin