2012
Autonomic control mechanism of maximal lower body negative pressure application
Selvaraj N, Shelley K, Silverman D, Stachenfeld N, Chon K. Autonomic control mechanism of maximal lower body negative pressure application. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2012, 2012: 3120-3123. PMID: 23366586, DOI: 10.1109/embc.2012.6346625.Peer-Reviewed Original ResearchConceptsLower body negative pressureDiastolic blood pressureHeart rate variabilityBlood pressure variabilityAutonomic control mechanismsPulse pressureSevere hemorrhageTermination of LBNPLower body negative pressure applicationMaximal lower body negative pressureSystolic blood pressure variabilityRoot mean square successive differenceBody negative pressureConscious human subjectsNegative pressure applicationMean square successive differenceSquare successive differenceHigh-frequency powerLBNP applicationSympathetic reflexesAutonomic reflexesSympathetic activityBaroreflex sensitivityBlood pressureLBNP tolerance
2010
Peripheral microvascular responses to norepinephrine in women with orthostatic intolerance
Wenner M, Taylor H, Stachenfeld N. Peripheral microvascular responses to norepinephrine in women with orthostatic intolerance. The FASEB Journal 2010, 24: 991.17-991.17. DOI: 10.1096/fasebj.24.1_supplement.991.17.Peer-Reviewed Original ResearchCumulative stress indexVasoconstrictor responsesAdrenergic responseMaximal lower body negative pressureLower body negative pressurePeripheral microvascular responseEffects of estradiolBody negative pressureFemale sex hormonesSkin blood flowEndogenous E2GnRH antagonistNE infusionDaily administrationMicrovascular responsesCutaneous microvasculatureOrthostatic intoleranceOrthostatic toleranceSex hormonesBlood flowSkin microvasculatureAdrenergic stimulationDay 4Hormone treatmentDay 13