2018
The L-type calcium channel blocker, isradipine, attenuates cue-induced cocaine-seeking by enhancing dopaminergic activity in the ventral tegmental area to nucleus accumbens pathway
Addy NA, Nunes EJ, Hughley SM, Small KM, Baracz SJ, Haight JL, Rajadhyaksha AM. The L-type calcium channel blocker, isradipine, attenuates cue-induced cocaine-seeking by enhancing dopaminergic activity in the ventral tegmental area to nucleus accumbens pathway. Neuropsychopharmacology 2018, 43: 2361-2372. PMID: 29773910, PMCID: PMC6180103, DOI: 10.1038/s41386-018-0080-2.Peer-Reviewed Original ResearchConceptsL-type calcium channelsCocaine relapseLever depressionVentral tegmental areaCocaine self-administration trainingOriginal training contextLight cue presentationSelf-administration trainingSubjective effectsCocaine-seeking behaviorTegmental areaBehavioral effectsCocaine's subjective effectsL-type calcium channel blockerCue presentationMale Sprague-Dawley ratsTraining contextCocaine cuesNucleus accumbens coreNatural rewardsDA receptor activationCalcium channel blockersSprague-Dawley ratsPhasic dopaminePotential therapeutic target
2017
Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens
Martínez-Rivera A, Hao J, Tropea TF, Giordano TP, Kosovsky M, Rice RC, Lee A, Huganir RL, Striessnig J, Addy NA, Han S, Rajadhyaksha AM. Enhancing VTA Cav1.3 L-type Ca2+ channel activity promotes cocaine and mood-related behaviors via overlapping AMPA receptor mechanisms in the nucleus accumbens. Molecular Psychiatry 2017, 22: 1735-1745. PMID: 28194001, PMCID: PMC5555837, DOI: 10.1038/mp.2017.9.Peer-Reviewed Original ResearchMeSH KeywordsAffectAnimalsCalcium Channels, L-TypeCocaineCocaine-Related DisordersConditioning, PsychologicalDepressionDisease Models, AnimalDopamine Uptake InhibitorsGenetic Association StudiesHumansMaleMice, Inbred C57BLMice, TransgenicMotor ActivityNucleus AccumbensPost-Synaptic DensityReceptors, AMPASocial BehaviorVentral Tegmental AreaConceptsDepressive-like behaviorCav1.3 L-type Ca2L-type Ca2Receptor mechanismsCalcium-permeable α-aminoCACNA1D geneCav1.3 channelsRole of Cav1.3Depressive-like phenotypeMood-related behaviorsDepression-related phenotypesSocial behavioral deficitsNeuropsychiatric symptomsBehavioral deficitsMood disordersCP-AMPARNAc shellRodent studiesGluA1 phosphorylationHuman studiesNAc corePlace preferenceBipolar disorderPsychomotor activityCav1.3
2010
Sensitization of Rapid Dopamine Signaling in the Nucleus Accumbens Core and Shell After Repeated Cocaine in Rats
Addy N, Daberkow D, Ford J, Garris P, Wightman R. Sensitization of Rapid Dopamine Signaling in the Nucleus Accumbens Core and Shell After Repeated Cocaine in Rats. Journal Of Neurophysiology 2010, 104: 922-931. PMID: 20554845, PMCID: PMC2934942, DOI: 10.1152/jn.00413.2010.Peer-Reviewed Original ResearchConceptsAcute cocaine challengeCocaine challengeNucleus accumbens coreWithdrawal periodDopamine sensitizationShort withdrawal periodDopamine releaseDopamine neurotransmissionFast-scan cyclic voltammetryAccumbens coreMale Sprague-Dawley ratsSubsequent cocaine challengeSprague-Dawley ratsLonger withdrawal periodsCocaine-treated subjectsPre-exposed subjectsRepeated CocaineDaily injectionsAcute cocaineDopaminergic responseCocaine exposureDopamine overflowNAc coreDopamine uptakeUptake inhibition