2019
Corticostriatal plasticity in the nucleus accumbens core
Bamford NS, Wang W. Corticostriatal plasticity in the nucleus accumbens core. Journal Of Neuroscience Research 2019, 97: 1559-1578. PMID: 31298422, PMCID: PMC6801067, DOI: 10.1002/jnr.24494.Peer-Reviewed Original ResearchConceptsPrefrontal cortical projectionsCortical projectionsNAc coreDrug reinstatementSaline-treated miceSpiny projection neuronsMotor learningNew therapeutic targetsNucleus accumbens coreUse of amphetaminesStriatal glutamateGlutamate releaseCortical stimulationPresynaptic depressionProjection neuronsStriatal circuitryD1 receptorsDrug challengeLocomotor sensitizationMale miceCorticostriatal plasticityGlutamatergic boutonsDopamine releaseNucleus accumbensParadoxical excitation
2016
Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice1,2,3
Storey GP, Gonzalez-Fernandez G, Bamford IJ, Hur M, McKinley JW, Heimbigner L, Minasyan A, Walwyn WM, Bamford NS. Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice1,2,3. ENeuro 2016, 3: eneuro.0095-15.2015. PMID: 26866057, PMCID: PMC4745180, DOI: 10.1523/eneuro.0095-15.2015.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAlpha7 Nicotinic Acetylcholine ReceptorAmphetamineAnimalsCentral Nervous System StimulantsCholinergic NeuronsConditioning, OperantCorpus StriatumDrug-Seeking BehaviorFemaleMaleMiceMice, Inbred C57BLMotor ActivityMotor CortexNeural PathwaysNeuronal PlasticityNicotineNicotinic AgonistsReceptors, NicotinicRewardSelf AdministrationConceptsCorticostriatal activityAmphetamine challengeGlutamate releaseLocomotor sensitizationDirect pathway medium spiny neuronsAmphetamine-induced locomotor sensitizationActive cholinergic interneuronsAmphetamine-seeking behaviorSubsequent drug challengeMedium spiny neuronsActivity ex vivoNicotinic acetylcholine receptorsDrug-seeking behaviorPeriod of abstinenceSelf-administer amphetamineDrugs of abuseSelf-administering miceDrug-taking behaviorDwelling catheterAmphetamine withdrawalCholinergic interneuronsGlutamatergic activityPresynaptic depressionPotentiating responseSpiny neurons
2013
Acetylcholine Encodes Long-Lasting Presynaptic Plasticity at Glutamatergic Synapses in the Dorsal Striatum after Repeated Amphetamine Exposure
Wang W, Darvas M, Storey GP, Bamford IJ, Gibbs JT, Palmiter RD, Bamford NS. Acetylcholine Encodes Long-Lasting Presynaptic Plasticity at Glutamatergic Synapses in the Dorsal Striatum after Repeated Amphetamine Exposure. Journal Of Neuroscience 2013, 33: 10405-10426. PMID: 23785153, PMCID: PMC3685836, DOI: 10.1523/jneurosci.0014-13.2013.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAdrenergic Uptake InhibitorsAmphetamineAnimalsCholine O-AcetyltransferaseDependovirusElectrophysiological PhenomenaExcitatory Postsynaptic PotentialsGenetic VectorsGlutamic AcidInterneuronsLocomotionMaleMaze LearningMiceMice, Inbred C57BLMice, KnockoutMotor ActivityNeostriatumNeuronal PlasticityPostural BalanceReceptors, Dopamine D1Receptors, Dopamine D2Receptors, PresynapticSynapsesConceptsGlutamate releaseCorticostriatal activityDirect pathway medium spiny neuronsMedium spiny neuronsCorticostriatal terminalsAcetylcholine releaseAmphetamine treatmentAmphetamine challengePresynaptic depressionAmphetamine exposurePresynaptic potentiationChronic decreaseSpiny neuronsDrug challengeLocomotor sensitizationGlutamatergic synapsesBrain slicesCorticostriatal signalingParkinson's diseaseDorsal striatumLocomotor responseDopamine regulationDrug dependenceStriatal activityActive interneurons
2012
Overinhibition of corticostriatal activity following prenatal cocaine exposure
Wang W, Nitulescu I, Lewis JS, Lemos JC, Bamford IJ, Posielski NM, Storey GP, Phillips PE, Bamford NS. Overinhibition of corticostriatal activity following prenatal cocaine exposure. Annals Of Neurology 2012, 73: 355-369. PMID: 23225132, PMCID: PMC3766752, DOI: 10.1002/ana.23805.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnalysis of VarianceAnesthetics, LocalAnimalsBiophysicsCerebral CortexCocaineCorpus StriatumDopamineDopamine AgentsDopamine Uptake InhibitorsDrug InteractionsElectric StimulationEmbryo, MammalianExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsExploratory BehaviorFemaleGABA AgentsGreen Fluorescent ProteinsHindlimb SuspensionIn Vitro TechniquesInterneuronsLidocaineMaleMiceMice, Inbred C57BLMice, TransgenicNerve Tissue ProteinsNeural InhibitionNeuronal PlasticityPatch-Clamp TechniquesPregnancyPrenatal Exposure Delayed EffectsQuinoxalinesQuinpiroleReceptors, GABA-ARotarod Performance TestSodium Channel BlockersStatistics, NonparametricTetrodotoxinConceptsPrenatal cocaine exposureCocaine exposureCorticostriatal activityTonic GABA currentsGABAA receptor antagonistBasal ganglia functionDopamine-dependent behaviorsCorticostriatal terminalsGABA interneuronsCorticostriatal synapsesDopamine-dependent plasticityGABAergic mechanismsGlutamate releaseGABAB receptorsMotor abnormalitiesGanglia functionTonic inhibitionReceptor antagonistStriatal synapsesAdolescent miceGABAergic signalingGABA currentsClinical studiesD2 receptorsPolysubstance abuse
2008
Repeated Exposure to Methamphetamine Causes Long-Lasting Presynaptic Corticostriatal Depression that Is Renormalized with Drug Readministration
Bamford NS, Zhang H, Joyce JA, Scarlis CA, Hanan W, Wu NP, André VM, Cohen R, Cepeda C, Levine MS, Harleton E, Sulzer D. Repeated Exposure to Methamphetamine Causes Long-Lasting Presynaptic Corticostriatal Depression that Is Renormalized with Drug Readministration. Neuron 2008, 58: 89-103. PMID: 18400166, PMCID: PMC2394729, DOI: 10.1016/j.neuron.2008.01.033.Peer-Reviewed Original ResearchConceptsAddiction-associated behaviorsDrug-experienced animalsSynaptic dopamine releaseCholinergic receptor systemsDrug readministrationLasting depressionCorticostriatal terminalsPresynaptic depressionSynaptic basisSynaptic effectsDopamine releaseD1 dopamineDrug reinstatementSynaptic changesDrug cravingReceptor systemLong-term maintenanceDepressionHabit learningReadministrationMethamphetamineExposureRelapseLong-term changes