2019
Localising movement disorders in childhood
Bamford NS, McVicar K. Localising movement disorders in childhood. The Lancet Child & Adolescent Health 2019, 3: 917-928. PMID: 31653548, PMCID: PMC7102738, DOI: 10.1016/s2352-4642(19)30330-x.Peer-Reviewed Original ResearchConceptsMovement disordersBasal gangliaBasal ganglia functionMajor movement disordersGanglia functionNew pharmacologicalTreatment decisionsClinical definitionSynaptic functionElectrophysiological approachesDisordersMotor learningGangliaChildrenIon channelsThalamusCortexPharmacologicalDiseasePhysiological frameworkDiagnosisNeuronsReceptorsDopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson’s Disease
McKinley JW, Shi Z, Kawikova I, Hur M, Bamford IJ, Sudarsana Devi SP, Vahedipour A, Darvas M, Bamford NS. Dopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson’s Disease. Neuron 2019, 103: 1056-1072.e6. PMID: 31324539, PMCID: PMC7102938, DOI: 10.1016/j.neuron.2019.06.013.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAmphetamineAnimalsCholinergic NeuronsCyclic AMP-Dependent Protein KinasesDisease Models, AnimalDopamineDopamine AgentsDopamine Plasma Membrane Transport ProteinsHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsInterneuronsMiceNeostriatumParkinson DiseasePatch-Clamp TechniquesReceptors, Dopamine D1Receptors, Dopamine D2Transcription, GeneticConceptsParkinson's diseaseDA deficiencyACh availabilityD1-type DA receptorsHyperpolarization-activated cation channelsRelease of acetylcholineStriatal acetylcholineDA receptorsStriatal interneuronsMotor deficitsDopamine deficiencyDA releasePharmacological treatmentResidual axonsStriatal synapsesMotor functionInterneuron functionAcetylcholineCognitive functionHCN channelsDiseaseCation channelsDopamineSpike timingDeficiencyCorticostriatal plasticity in the nucleus accumbens core
Bamford NS, Wang W. Corticostriatal plasticity in the nucleus accumbens core. Journal Of Neuroscience Research 2019, 97: 1559-1578. PMID: 31298422, PMCID: PMC6801067, DOI: 10.1002/jnr.24494.Peer-Reviewed Original ResearchConceptsPrefrontal cortical projectionsCortical projectionsNAc coreDrug reinstatementSaline-treated miceSpiny projection neuronsMotor learningNew therapeutic targetsNucleus accumbens coreUse of amphetaminesStriatal glutamateGlutamate releaseCortical stimulationPresynaptic depressionProjection neuronsStriatal circuitryD1 receptorsDrug challengeLocomotor sensitizationMale miceCorticostriatal plasticityGlutamatergic boutonsDopamine releaseNucleus accumbensParadoxical excitationThe Striatum’s Role in Executing Rational and Irrational Economic Behaviors
Bamford IJ, Bamford NS. The Striatum’s Role in Executing Rational and Irrational Economic Behaviors. The Neuroscientist 2019, 25: 475-490. PMID: 30678530, PMCID: PMC6656632, DOI: 10.1177/1073858418824256.Peer-Reviewed Original ResearchConceptsIrrational economic behaviorExecutive functionStriatum's roleMotor learningMotor movementsSensory stimulationExcitatory glutamatergic activityBehavioral economicsHabit formationNovel stimulationNeural pathwaysReflexive actionDecision makingReflexive movementsRational behaviorEconomic behaviorRational responseRewardDopamine releaseBehaviorStriatumGlutamatergic activityLearningCortexThalamus
2018
Dopamine’s Effects on Corticostriatal Synapses during Reward-Based Behaviors
Bamford NS, Wightman RM, Sulzer D. Dopamine’s Effects on Corticostriatal Synapses during Reward-Based Behaviors. Neuron 2018, 97: 494-510. PMID: 29420932, PMCID: PMC5808590, DOI: 10.1016/j.neuron.2018.01.006.Peer-Reviewed Original ResearchConceptsVariety of neurotransmittersPresynaptic filterCorticostriatal synapsesExcitatory inputsDopamine effectsExcitatory synapsesSynaptic pathwaysDopamine neurotransmissionLocal releaseSynapsesOperant responseCoordinated activationActivationResponseStriatumNeurotransmissionNeuron outputNeurotransmitters
2015
Dopamine-dependent corticostriatal synaptic filtering regulates sensorimotor behavior
Wong MY, Borgkvist A, Choi SJ, Mosharov EV, Bamford NS, Sulzer D. Dopamine-dependent corticostriatal synaptic filtering regulates sensorimotor behavior. Neuroscience 2015, 290: 594-607. PMID: 25637802, PMCID: PMC4494866, DOI: 10.1016/j.neuroscience.2015.01.022.Peer-Reviewed Original ResearchConceptsReceptor agonistD2-like receptor agonistDopamine D2-like receptor agonistsSensorimotor responsesNigrostriatal dopamine axonsD2 receptor activationD2 receptor agonistCB1 receptor antagonistLeft dorsal striatumSensorimotor behaviorSynaptic filteringCB1 endocannabinoid receptorLesioned miceCorticostriatal terminalsCorticostriatal synapsesSensorimotor deficitsReplacement therapyD2 agonistMetabotropic glutamateReceptor antagonistCB1 receptorsEndocannabinoid receptorsSynaptic activityControl disordersCorticostriatal activity
2012
Overinhibition of corticostriatal activity following prenatal cocaine exposure
Wang W, Nitulescu I, Lewis JS, Lemos JC, Bamford IJ, Posielski NM, Storey GP, Phillips PE, Bamford NS. Overinhibition of corticostriatal activity following prenatal cocaine exposure. Annals Of Neurology 2012, 73: 355-369. PMID: 23225132, PMCID: PMC3766752, DOI: 10.1002/ana.23805.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAnalysis of VarianceAnesthetics, LocalAnimalsBiophysicsCerebral CortexCocaineCorpus StriatumDopamineDopamine AgentsDopamine Uptake InhibitorsDrug InteractionsElectric StimulationEmbryo, MammalianExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsExploratory BehaviorFemaleGABA AgentsGreen Fluorescent ProteinsHindlimb SuspensionIn Vitro TechniquesInterneuronsLidocaineMaleMiceMice, Inbred C57BLMice, TransgenicNerve Tissue ProteinsNeural InhibitionNeuronal PlasticityPatch-Clamp TechniquesPregnancyPrenatal Exposure Delayed EffectsQuinoxalinesQuinpiroleReceptors, GABA-ARotarod Performance TestSodium Channel BlockersStatistics, NonparametricTetrodotoxinConceptsPrenatal cocaine exposureCocaine exposureCorticostriatal activityTonic GABA currentsGABAA receptor antagonistBasal ganglia functionDopamine-dependent behaviorsCorticostriatal terminalsGABA interneuronsCorticostriatal synapsesDopamine-dependent plasticityGABAergic mechanismsGlutamate releaseGABAB receptorsMotor abnormalitiesGanglia functionTonic inhibitionReceptor antagonistStriatal synapsesAdolescent miceGABAergic signalingGABA currentsClinical studiesD2 receptorsPolysubstance abuseRegulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core
Wang W, Dever D, Lowe J, Storey GP, Bhansali A, Eck EK, Nitulescu I, Weimer J, Bamford NS. Regulation of prefrontal excitatory neurotransmission by dopamine in the nucleus accumbens core. The Journal Of Physiology 2012, 590: 3743-3769. PMID: 22586226, PMCID: PMC3476631, DOI: 10.1113/jphysiol.2012.235200.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineAmphetamineAnimalsDopamineEndocannabinoidsGreen Fluorescent ProteinsMaleMiceMice, TransgenicNucleus AccumbensOptical ImagingPrefrontal CortexPresynaptic TerminalsPyridinium CompoundsQuaternary Ammonium CompoundsReceptors, AMPAReceptors, Dopamine D1Receptors, GlutamateReceptors, N-Methyl-D-AspartateSynaptic TransmissionConceptsD2 receptor-expressing cellsReceptor-expressing cellsMedium spiny neuronsSpiny neuronsExcitatory inputsD2 receptor-expressing medium spiny neuronsReceptor-expressing medium spiny neuronsGroup 1 metabotropic glutamate receptorsActivation of NMDAReceptor null miceMetabotropic glutamate receptorsBacterial artificial chromosome transgenic miceDopamine D1 receptorsBasal ganglia pathwaysConvergence of excitatoryNucleus accumbens coreCortical terminalsGlutamate releaseGlutamatergic inputsStriatonigral pathwayInhibitory modulationGlutamatergic signalsD1 receptorsSlice preparationGlutamatergic synapses
2004
Dopamine Modulates Release from Corticostriatal Terminals
Bamford NS, Robinson S, Palmiter RD, Joyce JA, Moore C, Meshul CK. Dopamine Modulates Release from Corticostriatal Terminals. Journal Of Neuroscience 2004, 24: 9541-9552. PMID: 15509741, PMCID: PMC6730145, DOI: 10.1523/jneurosci.2891-04.2004.Peer-Reviewed Original ResearchConceptsCorticostriatal terminalsMedium spiny neuronsD2 receptorsDD miceSpiny neuronsD2-like receptor agonist quinpiroleExtracellular striatal glutamateFM1-43 destainingNormal striatal functionReserpine-treated miceCortical glutamatergic neuronsReceptor agonist quinpiroleActivity-dependent releaseMidbrain dopamine neuronsFM1-43Styryl dye FM1-43Aberrant cytoarchitectureGlutamate densityStriatal stimulationStriatal glutamateDopamine depletionAgonist quinpiroleControl miceDopamine deficiencyGlutamatergic neuronsHeterosynaptic Dopamine Neurotransmission Selects Sets of Corticostriatal Terminals
Bamford NS, Zhang H, Schmitz Y, Wu NP, Cepeda C, Levine MS, Schmauss C, Zakharenko SS, Zablow L, Sulzer D. Heterosynaptic Dopamine Neurotransmission Selects Sets of Corticostriatal Terminals. Neuron 2004, 42: 653-663. PMID: 15157425, DOI: 10.1016/s0896-6273(04)00265-x.Peer-Reviewed Original ResearchMeSH KeywordsAfferent PathwaysAmphetamineAnimalsCalcium SignalingCerebral CortexDopamineElectric StimulationExcitatory Postsynaptic PotentialsExocytosisFeedbackGlutamic AcidMiceMice, Inbred C57BLMice, KnockoutNeostriatumNeural InhibitionPresynaptic TerminalsPyridinium CompoundsQuaternary Ammonium CompoundsReceptors, Dopamine D2Substantia NigraSynaptic TransmissionSynaptic VesiclesConceptsMedium spiny neuronsCorticostriatal terminalsDirect presynaptic effectIndividual presynaptic terminalsStriatal dopamine releaseEffects of dopamineHigh-frequency stimulationVoluntary motor movementDrugs of abuseCorticostriatal afferentsMSN excitabilityPresynaptic effectsCorticostriatal inputsCorticostriatal synapsesActivity of subsetsInhibitory modulationSpiny neuronsD2 receptorsDopamine releaseFrequency stimulationDopamine inputPresynaptic terminalsElectrical stimulationHeterosynaptic inhibitionSynaptic connections