2019
Corticostriatal plasticity in the nucleus accumbens core
Bamford NS, Wang W. Corticostriatal plasticity in the nucleus accumbens core. Journal Of Neuroscience Research 2019, 97: 1559-1578. PMID: 31298422, PMCID: PMC6801067, DOI: 10.1002/jnr.24494.Peer-Reviewed Original ResearchMeSH KeywordsAmphetamineAnimalsDopamineGlutamic AcidLocomotionLong-Term Synaptic DepressionMaleMice, Inbred C57BLNeuronal PlasticityNucleus AccumbensPrefrontal CortexReceptors, Dopamine D1ConceptsPrefrontal cortical projectionsCortical projectionsNAc coreDrug reinstatementSaline-treated miceSpiny projection neuronsMotor learningNew therapeutic targetsNucleus accumbens coreUse of amphetaminesStriatal glutamateGlutamate releaseCortical stimulationPresynaptic depressionProjection neuronsStriatal circuitryD1 receptorsDrug challengeLocomotor sensitizationMale miceCorticostriatal plasticityGlutamatergic boutonsDopamine releaseNucleus accumbensParadoxical excitation
2008
Repeated Exposure to Methamphetamine Causes Long-Lasting Presynaptic Corticostriatal Depression that Is Renormalized with Drug Readministration
Bamford NS, Zhang H, Joyce JA, Scarlis CA, Hanan W, Wu NP, André VM, Cohen R, Cepeda C, Levine MS, Harleton E, Sulzer D. Repeated Exposure to Methamphetamine Causes Long-Lasting Presynaptic Corticostriatal Depression that Is Renormalized with Drug Readministration. Neuron 2008, 58: 89-103. PMID: 18400166, PMCID: PMC2394729, DOI: 10.1016/j.neuron.2008.01.033.Peer-Reviewed Original ResearchConceptsAddiction-associated behaviorsDrug-experienced animalsSynaptic dopamine releaseCholinergic receptor systemsDrug readministrationLasting depressionCorticostriatal terminalsPresynaptic depressionSynaptic basisSynaptic effectsDopamine releaseD1 dopamineDrug reinstatementSynaptic changesDrug cravingReceptor systemLong-term maintenanceDepressionHabit learningReadministrationMethamphetamineExposureRelapseLong-term changes