2020
Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates
Micali N, Kim SK, Diaz-Bustamante M, Stein-O’Brien G, Seo S, Shin JH, Rash BG, Ma S, Wang Y, Olivares NA, Arellano JI, Maynard KR, Fertig EJ, Cross AJ, Bürli RW, Brandon NJ, Weinberger DR, Chenoweth JG, Hoeppner DJ, Sestan N, Rakic P, Colantuoni C, McKay RD. Variation of Human Neural Stem Cells Generating Organizer States In Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates. Cell Reports 2020, 31: 107599. PMID: 32375049, PMCID: PMC7357345, DOI: 10.1016/j.celrep.2020.107599.Peer-Reviewed Original ResearchConceptsNeural stem cellsNeuronal fateProliferative neural stem cellsStem cellsPluripotent linesTelencephalic fateRNA sequencingLineage tracingHuman neural stem cellsGlutamatergic excitatory neuronsMonkey brain sectionsNeuronal trajectoriesCell imagingCortical excitatoryCerebral cortexFateExcitatory neuronsBrain sectionsHuman telencephalonNeuropsychiatric disordersAcute transitionPluripotencyCellsCortexSequencing
2014
FGF2 and Insulin Signaling Converge to Regulate Cyclin D Expression in Multipotent Neural Stem Cells
Adepoju A, Micali N, Ogawa K, Hoeppner DJ, McKay RD. FGF2 and Insulin Signaling Converge to Regulate Cyclin D Expression in Multipotent Neural Stem Cells. Stem Cells 2014, 32: 770-778. PMID: 24155149, DOI: 10.1002/stem.1575.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationCyclin DDNAFemaleFibroblast Growth Factor 2InsulinIntracellular SpaceMiceMice, Inbred C57BLModels, BiologicalMultipotent Stem CellsNeural Stem CellsProtein BiosynthesisProto-Oncogene Proteins c-fosProto-Oncogene Proteins c-junSignal TransductionTranscription, GeneticConceptsNeural stem cellsMultipotent neural stem cellsStem cellsPost-transcriptional levelPI3K/Akt pathwayTyrosine kinase receptorsPhosphorylation of ERK1/2Cell statesInsulin signalProliferation controlCell lineagesFibroblast growth factorBasic fibroblast growth factorCyclin D expressionMultipotent cellsC-JunD mRNA levelsKinase receptorsNeural precursorsAkt pathwayCell expansionMultipotent natureCentral nervous systemDisease mechanismsC-fos