2022
The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans
Hawley NL, Duckham RL, Carlson JC, Naseri T, Reupena MS, Lameko V, Pomer A, Wetzel A, Selu M, Lupematisila V, Unasa F, Vesi L, Fatu T, Unasa S, Faasalele‐Savusa K, Rivara AC, Russell E, Delany JP, Viali S, Kershaw EE, Minster RL, Weeks DE, McGarvey ST. The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans. Obesity 2022, 30: 2468-2476. PMID: 36284436, PMCID: PMC10111239, DOI: 10.1002/oby.23559.Peer-Reviewed Original ResearchConceptsFat-free massType 2 diabetesFat distributionProtective effectBody compositionFavorable body fat distributionDual-energy X-ray absorptiometry-derived body compositionBody fat distributionGreater fat-free massPercent body fatBody size/compositionAssociation of genotypesRs373863828 genotypeVisceral adiposityHigher BMIAdult SamoansRole of fatGreater BMILean massBody fatLower oddsParadoxical associationTissue-specific mechanismsA alleleDiabetesCREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand
Russell EM, Carlson JC, Krishnan M, Hawley NL, Sun G, Cheng H, Naseri T, Reupena M, Viali S, Tuitele J, Major TJ, Miljkovic I, Merriman TR, Deka R, Weeks DE, McGarvey ST, Minster RL. CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand. BMJ Open Diabetes Research & Care 2022, 10: e002275. PMID: 35144939, PMCID: PMC8845200, DOI: 10.1136/bmjdrc-2021-002275.Peer-Reviewed Original ResearchConceptsBody mass indexType 2 diabetesAssociation of BMIHigher body mass indexMinor alleleType 2 diabetes riskCross-sectional associationsPacific Island populationsRs373863828 genotypeMass indexDiabetes riskHigher oddsLower oddsDiabetesObesityEvidence of differencesMissense variantsRs373863828Regression analysisGlucoseAssociationOddsIndirect effectsPolynesian individuals
2021
Cascades of diabetes and hypertension care in Samoa: Identifying gaps in the diagnosis, treatment, and control continuum – a cross-sectional study
LaMonica LC, McGarvey ST, Rivara AC, Sweetman CA, Naseri T, Reupena MS, Kadiamada H, Kocher E, Rojas-Carroll A, DeLany JP, Hawley NL. Cascades of diabetes and hypertension care in Samoa: Identifying gaps in the diagnosis, treatment, and control continuum – a cross-sectional study. The Lancet Regional Health - Western Pacific 2021, 18: 100313. PMID: 35024652, PMCID: PMC8669362, DOI: 10.1016/j.lanwpc.2021.100313.Peer-Reviewed Original ResearchNon-communicable diseasesChronic conditionsCommunity-based primary careCascade of careNational screening campaignPrimary care effortsCross-sectional studyRecent prevalence estimatesHypertension careGlycemic controlMiddle-income countriesInitial diagnosisPrimary careDistrict nursesHigh burdenSamoan adultsHypertensionCare approachDiabetesPrevalence estimatesSignificant burdenUnmet needCare effortsMinority HealthConvenience sampleA murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress
Kanshana JS, Mattila PE, Ewing MC, Wood AN, Schoiswohl G, Meyer AC, Kowalski A, Rosenthal SL, Gingras S, Kaufman BA, Lu R, Weeks DE, McGarvey ST, Minster RL, Hawley NL, Kershaw EE. A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress. PLOS ONE 2021, 16: e0251895. PMID: 34520472, PMCID: PMC8439463, DOI: 10.1371/journal.pone.0251895.Peer-Reviewed Original ResearchConceptsMurine modelGlucose homeostasisEnergy/glucose homeostasisOdds of diabetesOdds of obesityObesity risk variantsAlternative preclinical modelsPromotes obesityPreclinical modelsKnockin miceObesityDiabetesStrong heritable componentExtensive phenotypic analysisMissense variantsOrthologous variantDiseaseMiceOddsAdaptive transcriptional responseExtreme nutritional stressNutritional stressHomeostasisGenetic contributionRegulatory factorsSocial Support for Self-Care: Patient Strategies for Managing Diabetes and Hypertension in Rural Uganda
Tusubira AK, Nalwadda CK, Akiteng AR, Hsieh E, Ngaruiya C, Rabin TL, Katahoire A, Hawley NL, Kalyesubula R, Ssinabulya I, Schwartz JI, Armstrong-Hough M. Social Support for Self-Care: Patient Strategies for Managing Diabetes and Hypertension in Rural Uganda. Annals Of Global Health 2021, 87: 86. PMID: 34458110, PMCID: PMC8378074, DOI: 10.5334/aogh.3308.Peer-Reviewed Original ResearchConceptsNon-communicable diseasesSelf-care practicesPrescribed medicinesConventional medicinePatient's social support networkRural UgandaSelf-care activitiesBlood sugar levelsCross-sectional qualitative studyResource-limited settingsSelf-care effortsSocial support networksSocial supportNCD clinicsNineteen patientsAdult patientsHealth facilitiesPatientsPatient strategiesManaging diabetesHypertensionSelf-CareDiabetesDiagnostic testsLow-income countries1108-P: Care Cascade Engagement and Characteristics of Diabetes Awareness in Adult Samoans in 2010 and 2018
RIVARA A, RUSSELL E, VIALI S, REUPENA M, NASERI T, POMER A, MINSTER R, WEEKS D, MCGARVEY S, HAWLEY N. 1108-P: Care Cascade Engagement and Characteristics of Diabetes Awareness in Adult Samoans in 2010 and 2018. Diabetes 2021, 70 DOI: 10.2337/db21-1108-p.Peer-Reviewed Original ResearchGlycemic controlMedication useDiabetes awarenessAdult SamoansUnmet needSocioeconomic positionCare cascadeLifestyle scoreDiabetes prevalenceHigher BMICare engagementDiabetes careHigher oddsDisease awarenessLower oddsGreater oddsLogistic regressionDiabetesDoctor's diagnosisTime pointsNational InstituteOddsGenetic variantsDiagnosisCare
2020
Development of a discrete choice experiment to understand patient preferences for diabetes and hypertension management in rural Uganda
Moor S, Tusubira A, Akiteng A, Hsieh E, Ngaruiya C, Rabin T, Hawley N, Lipska K, Armstrong-Hough M, Nalwadda C, Nugent R, Kalyesubula R, Ssinabulya I, Schwartz J. Development of a discrete choice experiment to understand patient preferences for diabetes and hypertension management in rural Uganda. The Lancet Global Health 2020, 8: s22. DOI: 10.1016/s2214-109x(20)30163-7.Peer-Reviewed Original ResearchNon-communicable diseasesPatient preferencesHealth facilitiesCommon non-communicable diseasesRural UgandaCause of deathHealth care providersHealth service deliveryFormative qualitative researchAvailability of medicinesPeer support groupsHealth care systemPublic health officialsHypertension managementMiddle-income countriesRural patientsDiscrete choice experimentExpert consensusNakaseke districtPatientsCommunicable diseasesDiabetesLow-income countriesInternational content expertsHealth officials
2016
The growing threat of non-communicable disease to pregnancy health
Hawley N. The growing threat of non-communicable disease to pregnancy health. Pacific Journal Of Reproductive Health 2016, 1 DOI: 10.18313/pjrh.2016.909.Peer-Reviewed Original ResearchNon-communicable diseasesChild health effortsPrevalence of obesityRelated non-communicable diseasesSkilled health providersChronic hypertensionObstetric populationMaternal deathsNewborn deathsPregnancy healthPregnant womenGlobal maternalHealth effortsHealth providersAdequate nutritionEssential medicinesDiseaseDeathHypertensionPrematurityObesityDiabetesMaternalMortalityPrevalenceFood Label Use is associated with Dietary Quality and Dietary Patterns among Latinos with Type 2 Diabetes
SAMUEL G, Segura‐Pérez S, Shebl F, Hawley N, Damio G, Chhabra J, Vega‐López S, Fernandez M, Pérez‐Escamilla R. Food Label Use is associated with Dietary Quality and Dietary Patterns among Latinos with Type 2 Diabetes. The FASEB Journal 2016, 30 DOI: 10.1096/fasebj.30.1_supplement.674.41.Peer-Reviewed Original ResearchType 2 diabetesFood frequency questionnaireDietary patternsFood label useDietary qualityLabel useDietary intakeHealth disparitiesType 2 diabetes careDiabetes-related knowledgeHealthy dietary patternMultivariable logistic regressionHealthy Eating IndexHealthy food choicesEthnic health disparitiesEducation levelFFQ dataFrequency questionnaireIndependent determinantsDiabetes careSnack patternsDiet managementLatino adultsDiabetesType 2
2015
Obesity and Diabetes in Pacific Islanders: the Current Burden and the Need for Urgent Action
Hawley NL, McGarvey ST. Obesity and Diabetes in Pacific Islanders: the Current Burden and the Need for Urgent Action. Current Diabetes Reports 2015, 15: 29. PMID: 25809458, DOI: 10.1007/s11892-015-0594-5.Peer-Reviewed Original Research