MiR-145 functions as a tumor-suppressive RNA by targeting Sox9 and adducin 3 in human glioma cells
Rani S, Rathod S, Karthik S, Kaur N, Muzumdar D, Shiras A. MiR-145 functions as a tumor-suppressive RNA by targeting Sox9 and adducin 3 in human glioma cells. Neuro-Oncology 2013, 15: 1302-1316. PMID: 23814265, PMCID: PMC3779040, DOI: 10.1093/neuonc/not090.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisBlotting, WesternBrain NeoplasmsCalmodulin-Binding ProteinsCell AdhesionCell CycleCell MovementCell ProliferationGliomaHumansMiceMice, Inbred NODMice, SCIDMicroRNAsNeoplastic Stem CellsReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSOX9 Transcription FactorConceptsAdducin 3MiR-145Overexpression of moleculesCell proliferationGlioma cellsHNGC-2 cellsModel cell systemMiR-145 promoterTumor suppressive functionMiR-145 functionsGuanine (CpG) islandsMiR-145 overexpressionEctopic expressionGrowth-suppressive effectsMiR-145 lossHuman glioma cellsCell adhesionC-MycFunctional studiesN-cadherinGlioma cell linesGlioblastoma cellsN-mycSOX9E-cadherinWnt3a mediated activation of Wnt/β-catenin signaling promotes tumor progression in glioblastoma
Kaur N, Chettiar S, Rathod S, Rath P, Muzumdar D, Shaikh M, Shiras A. Wnt3a mediated activation of Wnt/β-catenin signaling promotes tumor progression in glioblastoma. Molecular And Cellular Neuroscience 2013, 54: 44-57. PMID: 23337036, DOI: 10.1016/j.mcn.2013.01.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain NeoplasmsCell Line, TumorCell MovementCell ProliferationCell Transformation, NeoplasticDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticGene SilencingGlioblastomaHumansMiceMice, Inbred NODMice, SCIDNeoplastic Stem CellsTranscription, GeneticWnt Signaling PathwayWnt1 ProteinWnt3A ProteinConceptsWnt/β-cateninDevelopmental signaling pathwaysTumor progressionΒ-cateninCancer stem cell hypothesisRole of Wnt3aStem cell hypothesisIntra-cranial tumoursStem-like cellsNovel therapeutic strategiesGlioma stemPromotes Tumor ProgressionSignaling pathwaysCell migrationDistinct populationsCell hypothesisGlioma tumorigenesisCell proliferationWnt3aTherapeutic strategiesMalignant transformationTumor developmentPathwayWntGlioma cells