Dlxin-1, a MAGE family protein, induces accelerated neurite outgrowth and cell survival by enhanced and early activation of MEK and Akt signalling pathways in PC12 cells
Reddy E, Chettiar S, Kaur N, Shepal V, Shiras A. Dlxin-1, a MAGE family protein, induces accelerated neurite outgrowth and cell survival by enhanced and early activation of MEK and Akt signalling pathways in PC12 cells. Experimental Cell Research 2010, 316: 2220-2236. PMID: 20595047, DOI: 10.1016/j.yexcr.2010.05.030.Peer-Reviewed Original ResearchConceptsDlxin-1MAGE homology domainCell survivalPC12 cellsPresence of NGFNeuronal differentiationDiverse cellular functionsMAGE family proteinsCell cycle progressionTranscriptional regulationHomology domainCellular functionsFamily proteinsNeuronal survivalDevelopmental apoptosisEnhanced neuritogenesisCycle progressionSignaling pathwaysMEK pathwayPharmacological inhibitorsCell deathAkt pathwayUnique regionAmino acidsEarly activation