2013
Wnt3a mediated activation of Wnt/β-catenin signaling promotes tumor progression in glioblastoma
Kaur N, Chettiar S, Rathod S, Rath P, Muzumdar D, Shaikh M, Shiras A. Wnt3a mediated activation of Wnt/β-catenin signaling promotes tumor progression in glioblastoma. Molecular And Cellular Neuroscience 2013, 54: 44-57. PMID: 23337036, DOI: 10.1016/j.mcn.2013.01.001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrain NeoplasmsCell Line, TumorCell MovementCell ProliferationCell Transformation, NeoplasticDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticGene SilencingGlioblastomaHumansMiceMice, Inbred NODMice, SCIDNeoplastic Stem CellsTranscription, GeneticWnt Signaling PathwayWnt1 ProteinWnt3A ProteinConceptsWnt/β-cateninDevelopmental signaling pathwaysTumor progressionΒ-cateninCancer stem cell hypothesisRole of Wnt3aStem cell hypothesisIntra-cranial tumoursStem-like cellsNovel therapeutic strategiesGlioma stemPromotes Tumor ProgressionSignaling pathwaysCell migrationDistinct populationsCell hypothesisGlioma tumorigenesisCell proliferationWnt3aTherapeutic strategiesMalignant transformationTumor developmentPathwayWntGlioma cells
2010
Dlxin-1, a MAGE family protein, induces accelerated neurite outgrowth and cell survival by enhanced and early activation of MEK and Akt signalling pathways in PC12 cells
Reddy E, Chettiar S, Kaur N, Shepal V, Shiras A. Dlxin-1, a MAGE family protein, induces accelerated neurite outgrowth and cell survival by enhanced and early activation of MEK and Akt signalling pathways in PC12 cells. Experimental Cell Research 2010, 316: 2220-2236. PMID: 20595047, DOI: 10.1016/j.yexcr.2010.05.030.Peer-Reviewed Original ResearchConceptsDlxin-1MAGE homology domainCell survivalPC12 cellsPresence of NGFNeuronal differentiationDiverse cellular functionsMAGE family proteinsCell cycle progressionTranscriptional regulationHomology domainCellular functionsFamily proteinsNeuronal survivalDevelopmental apoptosisEnhanced neuritogenesisCycle progressionSignaling pathwaysMEK pathwayPharmacological inhibitorsCell deathAkt pathwayUnique regionAmino acidsEarly activation